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- W3199071808 abstract "Prior literature has suggested that follicular fluid hormonal milieu may affect oocyte yield/quality. In this secondary analysis of the TAmoxifen or Letrozole in Estrogen Sensitive tumors (TALES) trial, we aimed to investigate if concurrent administration of letrozole vs tamoxifen vs no added treatment affects hormonal composition and size of stimulated ovarian follicles. TALES is a randomized controlled trial of IVF stimulation outcomes for non-metastatic estrogen receptor (ER) positive breast cancer patients stimulated with gonadotropins, randomized to concurrent administration of tamoxifen 20 mg, letrozole 5 mg, or no added treatment (for ER negative controls). We investigated characteristics of the largest follicle on both sides in terms of 6 different hormones: FSH, LH, E2, P4, Testosterone (T), and AMH. These hormones were chosen based on literature suggesting possible effect on follicular/oocyte development, as well as biologic plausibility to be affected by the mechanism of letrozole or tamoxifen. We used ANOVA/Kruskal-Wallis, logistic, and linear regression to examine differences in follicular hormone levels and size between trial arms, and the relationship between these metrics and mature oocyte yield. We included data from total 246 follicles (94 letrozole, 82 tamoxifen, and 70 control) from 123 unique participants, with average age 34.0 years. E2 (p<0.001, significantly lower in letrozole group) and T (significantly higher in letrozole group, p=0.03) were significantly different between the groups, while other hormone levels and follicle size were similar (see Table below). There was no significant association of mature oocyte by follicle size, hormone levels, or trial arm. Concurrent administration of letrozole with gonadotropins affects follicular E2 and T concentrations compared to Tamoxifen/control. Tamoxifen follicular fluid hormone concentration is similar to control. Mature oocyte yield is similar across groups." @default.
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- W3199071808 date "2021-09-01" @default.
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- W3199071808 title "CHARACTERISTICS OF FOLLICULAR FLUID IN THE TALES RANDOMIZED CONTROLLED TRIAL" @default.
- W3199071808 doi "https://doi.org/10.1016/j.fertnstert.2021.07.585" @default.
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