FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199111570> ?p ?o ?g. }

• W3199111570 abstract "Abstract Study Objectives To examine in a subsample at the screening phase of a clinical trial of a β-amyloid (Aβ) antibody whether disturbed sleep and altered 24-hour rest/activity rhythms (RARs) may serve as markers of preclinical Alzheimer’s disease (AD). Methods Overall, 26 Aβ-positive (Aβ+) and 33 Aβ-negative (Aβ−) cognitively unimpaired participants (mean age = 71.3 ± 4.6 years, 59% women) from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) and the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies, respectively, wore actigraphs for 5.66 ± 0.88 24-hour periods. We computed standard sleep parameters, standard RAR metrics (mean estimating statistic of rhythm, amplitude, acrophase, interdaily stability, intradaily variability, relative amplitude), and performed a novel RAR analysis (function-on-scalar regression [FOSR]). Results We were unable to detect any differences between Aβ+ and Aβ− participants in standard sleep parameters or RAR metrics with our sample size. When we used novel FOSR methods, however, Aβ+ participants had lower activity levels than Aβ− participants in the late night through early morning (11:30 pm to 3:00 am), and higher levels in the early morning (4:30 am to 8:30 am) and from midday through late afternoon (12:30 pm to 5:30 pm; all p &lt; .05). Aβ+ participants also had higher variability in activity across days from 9:30 pm to 1:00 am and 4:30 am to 8:30 am, and lower variability from 2:30 am to 3:30 am (all p &lt; .05). Conclusions Although we found no association of preclinical AD with standard actigraphic sleep or RAR metrics, a novel data-driven analytic method identified temporally “local” RAR alterations in preclinical AD." @default.
• W3199111570 created "2021-09-27" @default.
• W3199111570 creator A5001795846 @default.
• W3199111570 creator A5003708236 @default.
• W3199111570 creator A5018779616 @default.
• W3199111570 creator A5022356562 @default.
• W3199111570 creator A5031710633 @default.
• W3199111570 creator A5033585095 @default.
• W3199111570 creator A5034225628 @default.
• W3199111570 creator A5048005267 @default.
• W3199111570 creator A5056034076 @default.
• W3199111570 creator A5060830674 @default.
• W3199111570 creator A5061934117 @default.
• W3199111570 creator A5068057129 @default.
• W3199111570 creator A5069682721 @default.
• W3199111570 creator A5077221648 @default.
• W3199111570 creator A5080559044 @default.
• W3199111570 creator A5087403454 @default.
• W3199111570 creator A5090940361 @default.
• W3199111570 date "2021-03-01" @default.
• W3199111570 modified "2023-10-16" @default.
• W3199111570 title "Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies" @default.
• W3199111570 cites W1277966809 @default.
• W3199111570 cites W1847168837 @default.
• W3199111570 cites W1892367668 @default.
• W3199111570 cites W1945752929 @default.
• W3199111570 cites W1983882084 @default.
• W3199111570 cites W1991952617 @default.
• W3199111570 cites W1992999217 @default.
• W3199111570 cites W1996802297 @default.
• W3199111570 cites W2008854521 @default.
• W3199111570 cites W2013333500 @default.
• W3199111570 cites W2017247763 @default.
• W3199111570 cites W2058161128 @default.
• W3199111570 cites W2065565096 @default.
• W3199111570 cites W2081402812 @default.
• W3199111570 cites W2085301512 @default.
• W3199111570 cites W2089650868 @default.
• W3199111570 cites W2109046615 @default.
• W3199111570 cites W2109053359 @default.
• W3199111570 cites W2112579276 @default.
• W3199111570 cites W2117180085 @default.
• W3199111570 cites W2121991145 @default.
• W3199111570 cites W2128961718 @default.
• W3199111570 cites W2143790126 @default.
• W3199111570 cites W2148080316 @default.
• W3199111570 cites W2153203890 @default.
• W3199111570 cites W2167311298 @default.
• W3199111570 cites W2174100850 @default.
• W3199111570 cites W2376868110 @default.
• W3199111570 cites W2473313434 @default.
• W3199111570 cites W2553026365 @default.
• W3199111570 cites W2585129841 @default.
• W3199111570 cites W2592503176 @default.
• W3199111570 cites W2747130248 @default.
• W3199111570 cites W2792021696 @default.
• W3199111570 cites W3014487247 @default.
• W3199111570 doi "https://doi.org/10.1093/sleepadvances/zpab015" @default.
• W3199111570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8519157" @default.
• W3199111570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34661109" @default.
• W3199111570 hasPublicationYear "2021" @default.
• W3199111570 type Work @default.
• W3199111570 sameAs 3199111570 @default.
• W3199111570 citedByCount "6" @default.
• W3199111570 countsByYear W31991115702022 @default.
• W3199111570 countsByYear W31991115702023 @default.
• W3199111570 crossrefType "journal-article" @default.
• W3199111570 hasAuthorship W3199111570A5001795846 @default.
• W3199111570 hasAuthorship W3199111570A5003708236 @default.
• W3199111570 hasAuthorship W3199111570A5018779616 @default.
• W3199111570 hasAuthorship W3199111570A5022356562 @default.
• W3199111570 hasAuthorship W3199111570A5031710633 @default.
• W3199111570 hasAuthorship W3199111570A5033585095 @default.
• W3199111570 hasAuthorship W3199111570A5034225628 @default.
• W3199111570 hasAuthorship W3199111570A5048005267 @default.
• W3199111570 hasAuthorship W3199111570A5056034076 @default.
• W3199111570 hasAuthorship W3199111570A5060830674 @default.
• W3199111570 hasAuthorship W3199111570A5061934117 @default.
• W3199111570 hasAuthorship W3199111570A5068057129 @default.
• W3199111570 hasAuthorship W3199111570A5069682721 @default.
• W3199111570 hasAuthorship W3199111570A5077221648 @default.
• W3199111570 hasAuthorship W3199111570A5080559044 @default.
• W3199111570 hasAuthorship W3199111570A5087403454 @default.
• W3199111570 hasAuthorship W3199111570A5090940361 @default.
• W3199111570 hasBestOaLocation W31991115701 @default.
• W3199111570 hasConcept C121446783 @default.
• W3199111570 hasConcept C126322002 @default.
• W3199111570 hasConcept C134018914 @default.
• W3199111570 hasConcept C143998085 @default.
• W3199111570 hasConcept C15744967 @default.
• W3199111570 hasConcept C19720800 @default.
• W3199111570 hasConcept C2776925932 @default.
• W3199111570 hasConcept C2777910003 @default.
• W3199111570 hasConcept C2778996325 @default.
• W3199111570 hasConcept C2779134260 @default.
• W3199111570 hasConcept C502032728 @default.
• W3199111570 hasConcept C71924100 @default.
• W3199111570 hasConceptScore W3199111570C121446783 @default.
• W3199111570 hasConceptScore W3199111570C126322002 @default.
• W3199111570 hasConceptScore W3199111570C134018914 @default.

• next