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• W3199117589 endingPage "10189" @default.
• W3199117589 startingPage "10189" @default.
• W3199117589 abstract "Dry and eczema-prone skin conditions such as atopic dermatitis and xerotic eczema primarily indicate an impaired skin barrier function, which leads to chronic pruritus. Here, we investigated the effects of a novel emollient containing H.ECMTM liposome, which contains a soluble proteoglycan in combination with hydrolyzed collagen and hyaluronic acid. A prospective, single-arm study was conducted on 25 participants with mild atopic dermatitis or dry skin to assess the hydration and anti-inflammatory effect of the novel emollient applied daily over four weeks. All efficacy parameters, including itching severity, transepidermal water loss, and skin hydration, improved significantly after four weeks. The in vitro and ex vivo studies confirmed the restoration of the skin's barrier function. The study revealed the clinical and laboratory efficacy of H.ECMTM liposome in reducing itching and improving the skin's barrier integrity. Thus, the use of H.ECMTM liposome can be considered a therapeutic option for dry and eczema-prone skin." @default.
• W3199117589 created "2021-09-27" @default.
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• W3199117589 date "2021-09-22" @default.
• W3199117589 modified "2023-10-17" @default.
• W3199117589 title "Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study" @default.
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• W3199117589 doi "https://doi.org/10.3390/ijms221910189" @default.
• W3199117589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508667" @default.
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• W3199117589 hasPublicationYear "2021" @default.
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