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- W3199135772 abstract "Astrocytes are a large group of glial cells that perform a variety of physiological functions in the nervous system. They provide trophic, as well as structural, support to neuronal cells. Astrocytes are also involved in neuroinflammatory processes contributing to neuronal dysfunction and death. Growing evidence suggests important roles for astrocytes in non-cell autonomous mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Understanding these mechanisms necessitates the combined use of animal and human cell-based experimental model systems, at least in part because human astrocytes display a number of unique features that cannot be recapitulated in animal models. Human induced pluripotent stem cell (hiPSC)-based approaches provide the opportunity to generate disease-relevant human astrocytes to investigate the roles of these cells in ALS. These approaches are facing the growing recognition that there are heterogenous populations of astrocytes in the nervous system which are not functionally equivalent. This review will discuss the importance of taking astrocyte heterogeneity into consideration when designing hiPSC-based strategies aimed at generating the most informative preparations to study the contribution of astrocytes to ALS pathophysiology." @default.
- W3199135772 created "2021-09-27" @default.
- W3199135772 creator A5083828029 @default.
- W3199135772 date "2021-09-17" @default.
- W3199135772 modified "2023-10-15" @default.
- W3199135772 title "Taking Cellular Heterogeneity Into Consideration When Modeling Astrocyte Involvement in Amyotrophic Lateral Sclerosis Using Human Induced Pluripotent Stem Cells" @default.
- W3199135772 cites W1485665912 @default.
- W3199135772 cites W1543130539 @default.
- W3199135772 cites W1553983967 @default.
- W3199135772 cites W1556269168 @default.
- W3199135772 cites W1920198302 @default.
- W3199135772 cites W1940519961 @default.
- W3199135772 cites W1973459975 @default.
- W3199135772 cites W1974402193 @default.
- W3199135772 cites W1977838764 @default.
- W3199135772 cites W1978120353 @default.
- W3199135772 cites W1989633016 @default.
- W3199135772 cites W1993064034 @default.
- W3199135772 cites W1993321996 @default.
- W3199135772 cites W1994350510 @default.
- W3199135772 cites W2009867508 @default.
- W3199135772 cites W2012851706 @default.
- W3199135772 cites W2023273195 @default.
- W3199135772 cites W2029606645 @default.
- W3199135772 cites W2032706712 @default.
- W3199135772 cites W2046313247 @default.
- W3199135772 cites W2052935486 @default.
- W3199135772 cites W2055129010 @default.
- W3199135772 cites W2066058435 @default.
- W3199135772 cites W2066557327 @default.
- W3199135772 cites W2070953412 @default.
- W3199135772 cites W2073740291 @default.
- W3199135772 cites W2075187155 @default.
- W3199135772 cites W2076355203 @default.
- W3199135772 cites W2079312451 @default.
- W3199135772 cites W2084566588 @default.
- W3199135772 cites W2089187494 @default.
- W3199135772 cites W2089855415 @default.
- W3199135772 cites W2091849737 @default.
- W3199135772 cites W2093441343 @default.
- W3199135772 cites W2096386031 @default.
- W3199135772 cites W2101369162 @default.
- W3199135772 cites W2107660300 @default.
- W3199135772 cites W2109992632 @default.
- W3199135772 cites W2110289399 @default.
- W3199135772 cites W2111027979 @default.
- W3199135772 cites W2113887671 @default.
- W3199135772 cites W2118661818 @default.
- W3199135772 cites W2121588319 @default.
- W3199135772 cites W2121642311 @default.
- W3199135772 cites W2125883247 @default.
- W3199135772 cites W2131955939 @default.
- W3199135772 cites W2135107819 @default.
- W3199135772 cites W2144117535 @default.
- W3199135772 cites W2144681414 @default.
- W3199135772 cites W2158626764 @default.
- W3199135772 cites W2164143668 @default.
- W3199135772 cites W2191292005 @default.
- W3199135772 cites W2205666820 @default.
- W3199135772 cites W2292218845 @default.
- W3199135772 cites W2386409166 @default.
- W3199135772 cites W2522600469 @default.
- W3199135772 cites W2559796913 @default.
- W3199135772 cites W2564558365 @default.
- W3199135772 cites W2572710398 @default.
- W3199135772 cites W2599825252 @default.
- W3199135772 cites W2606147479 @default.
- W3199135772 cites W2607559970 @default.
- W3199135772 cites W2611225933 @default.
- W3199135772 cites W2618231866 @default.
- W3199135772 cites W2621213207 @default.
- W3199135772 cites W2624682934 @default.
- W3199135772 cites W2700330585 @default.
- W3199135772 cites W2735021289 @default.
- W3199135772 cites W2747850876 @default.
- W3199135772 cites W2766914945 @default.
- W3199135772 cites W2767003231 @default.
- W3199135772 cites W2772825296 @default.
- W3199135772 cites W2777525962 @default.
- W3199135772 cites W2794585550 @default.
- W3199135772 cites W2799543599 @default.
- W3199135772 cites W2802514488 @default.
- W3199135772 cites W2809140780 @default.
- W3199135772 cites W2887720590 @default.
- W3199135772 cites W2893955447 @default.
- W3199135772 cites W2899460164 @default.
- W3199135772 cites W2906758571 @default.
- W3199135772 cites W2911503339 @default.
- W3199135772 cites W2917543658 @default.
- W3199135772 cites W2922043513 @default.
- W3199135772 cites W2923484387 @default.
- W3199135772 cites W2935799992 @default.
- W3199135772 cites W2941548286 @default.
- W3199135772 cites W2944734416 @default.
- W3199135772 cites W2949744102 @default.
- W3199135772 cites W2951890520 @default.
- W3199135772 cites W2953476988 @default.
- W3199135772 cites W2956113551 @default.
- W3199135772 cites W2957051172 @default.
- W3199135772 cites W2960111824 @default.