Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199140561> ?p ?o ?g. }
- W3199140561 endingPage "174480692110452" @default.
- W3199140561 startingPage "174480692110452" @default.
- W3199140561 abstract "Interferons (IFNs) are cytokines secreted by infected cells that can interfere with viral replication. Besides activating antiviral defenses, type I IFNs also exhibit diverse biological functions. IFN-β has been shown to have a protective effect against neurotoxic and inflammatory insults on neurons. Therefore, we aimed to investigate the possible role of IFN-β in reducing mechanical allodynia caused by Complete Freund’s Adjuvant (CFA) injection in rats. We assessed the antinociceptive effect of intrathecal IFN-β in naïve rats and the rats with CFA–induced inflammatory pain. After the behavioral test, the spinal cords of the rats were harvested for western blot and immunohistochemical double staining. We found that intrathecal administration of IFN-β in naïve rats can significantly increase the paw withdrawal threshold and paw withdrawal latency. Further, the intrathecal injection of a neutralizing IFN-β antibody can reduce the paw withdrawal threshold and paw withdrawal latency, suggesting that IFN-β is produced in the spinal cord in normal conditions and serves as a tonic inhibitor of pain. In addition, intrathecal injection of IFN-β at dosages from 1000 U to 10000 U demonstrates a significant transient dose-dependent inhibition of CFA-induced inflammatory pain. This analgesic effect is reversed by intrathecal naloxone, suggesting that IFN-β produces an analgesic effect through central opioid receptor-mediated signaling. Increased expression of phospho-µ-opioid receptors after IFN-β injection was observed on western blot, and immunohistochemical staining showed that µ-opioids co-localized with IFN-α/βR in the dorsal horn of the spinal cord. The findings of this study demonstrate that the analgesic effect of IFN-β is through µ-opioid receptors activation in spial cord." @default.
- W3199140561 created "2021-09-27" @default.
- W3199140561 creator A5016456315 @default.
- W3199140561 creator A5017199455 @default.
- W3199140561 creator A5029326624 @default.
- W3199140561 creator A5030163786 @default.
- W3199140561 creator A5046129174 @default.
- W3199140561 creator A5058937403 @default.
- W3199140561 creator A5061465016 @default.
- W3199140561 creator A5086407424 @default.
- W3199140561 creator A5091557858 @default.
- W3199140561 date "2021-01-01" @default.
- W3199140561 modified "2023-09-27" @default.
- W3199140561 title "Interferon-β suppresses inflammatory pain through activating µ-opioid receptor" @default.
- W3199140561 cites W144396922 @default.
- W3199140561 cites W1970418719 @default.
- W3199140561 cites W1974215244 @default.
- W3199140561 cites W1977149890 @default.
- W3199140561 cites W2014007136 @default.
- W3199140561 cites W2042391178 @default.
- W3199140561 cites W2043323520 @default.
- W3199140561 cites W2044079984 @default.
- W3199140561 cites W2045524629 @default.
- W3199140561 cites W2052069735 @default.
- W3199140561 cites W2060926084 @default.
- W3199140561 cites W2062004514 @default.
- W3199140561 cites W2062372394 @default.
- W3199140561 cites W2065794552 @default.
- W3199140561 cites W2067491197 @default.
- W3199140561 cites W2068368057 @default.
- W3199140561 cites W2075413744 @default.
- W3199140561 cites W2077508656 @default.
- W3199140561 cites W2078844752 @default.
- W3199140561 cites W2085237060 @default.
- W3199140561 cites W2089649991 @default.
- W3199140561 cites W2091129202 @default.
- W3199140561 cites W2103351070 @default.
- W3199140561 cites W2105921211 @default.
- W3199140561 cites W2117116131 @default.
- W3199140561 cites W2121891790 @default.
- W3199140561 cites W2124720965 @default.
- W3199140561 cites W2132309323 @default.
- W3199140561 cites W2138505714 @default.
- W3199140561 cites W2171448408 @default.
- W3199140561 cites W2172201406 @default.
- W3199140561 cites W2326018726 @default.
- W3199140561 cites W2339096746 @default.
- W3199140561 cites W2525098889 @default.
- W3199140561 cites W2596476214 @default.
- W3199140561 cites W2619143287 @default.
- W3199140561 cites W2738617843 @default.
- W3199140561 cites W2972147021 @default.
- W3199140561 cites W2981995591 @default.
- W3199140561 cites W3008779319 @default.
- W3199140561 cites W3014221955 @default.
- W3199140561 cites W3120077678 @default.
- W3199140561 cites W4234158842 @default.
- W3199140561 doi "https://doi.org/10.1177/17448069211045211" @default.
- W3199140561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34517736" @default.
- W3199140561 hasPublicationYear "2021" @default.
- W3199140561 type Work @default.
- W3199140561 sameAs 3199140561 @default.
- W3199140561 citedByCount "4" @default.
- W3199140561 countsByYear W31991405612023 @default.
- W3199140561 crossrefType "journal-article" @default.
- W3199140561 hasAuthorship W3199140561A5016456315 @default.
- W3199140561 hasAuthorship W3199140561A5017199455 @default.
- W3199140561 hasAuthorship W3199140561A5029326624 @default.
- W3199140561 hasAuthorship W3199140561A5030163786 @default.
- W3199140561 hasAuthorship W3199140561A5046129174 @default.
- W3199140561 hasAuthorship W3199140561A5058937403 @default.
- W3199140561 hasAuthorship W3199140561A5061465016 @default.
- W3199140561 hasAuthorship W3199140561A5086407424 @default.
- W3199140561 hasAuthorship W3199140561A5091557858 @default.
- W3199140561 hasBestOaLocation W31991405611 @default.
- W3199140561 hasConcept C104317684 @default.
- W3199140561 hasConcept C118552586 @default.
- W3199140561 hasConcept C126322002 @default.
- W3199140561 hasConcept C15490471 @default.
- W3199140561 hasConcept C170493617 @default.
- W3199140561 hasConcept C185592680 @default.
- W3199140561 hasConcept C203014093 @default.
- W3199140561 hasConcept C2776178377 @default.
- W3199140561 hasConcept C2776415932 @default.
- W3199140561 hasConcept C2777107010 @default.
- W3199140561 hasConcept C2779886867 @default.
- W3199140561 hasConcept C2780775167 @default.
- W3199140561 hasConcept C2780820201 @default.
- W3199140561 hasConcept C2781063702 @default.
- W3199140561 hasConcept C55493867 @default.
- W3199140561 hasConcept C71924100 @default.
- W3199140561 hasConcept C98274493 @default.
- W3199140561 hasConceptScore W3199140561C104317684 @default.
- W3199140561 hasConceptScore W3199140561C118552586 @default.
- W3199140561 hasConceptScore W3199140561C126322002 @default.
- W3199140561 hasConceptScore W3199140561C15490471 @default.
- W3199140561 hasConceptScore W3199140561C170493617 @default.
- W3199140561 hasConceptScore W3199140561C185592680 @default.