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- W3199146875 abstract "Summary Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets. Current studies of gastrulation use a wide range of model organisms and emphasize either large-scale tissue processes or dynamics of individual cells and cell groups 1,2,11–13,3–10 . Here we take a step towards bridging these complementary strategies and deconstruct early stages of gastrulation in the entire Drosophila embryo, where transcriptional patterns in the blastoderm give rise to region-specific cell behaviors. Our approach relies on an integrated computational framework for cell segmentation and tracking and on efficient algorithms for event detection. Our results reveal how thousands of cell shape changes, divisions, and intercalations drive large-scale deformations of the patterned blastoderm, setting the stage for systems-level dissection of a pivotal step in animal development." @default.
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- W3199146875 date "2021-09-18" @default.
- W3199146875 modified "2023-10-14" @default.
- W3199146875 title "Deconstructing Gastrulation at the Single Cell Level" @default.
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- W3199146875 doi "https://doi.org/10.1101/2021.09.16.460711" @default.
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