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• W3199156975 endingPage "244" @default.
• W3199156975 startingPage "223" @default.
• W3199156975 abstract "Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them. Pathogenesis of neurological disorders is found to be associated with dysregulation of gut-brain axis. Some gut bacteria metabolites are found to be directly associated with the increase in reactive oxygen species levels, one of the most important risk factors of neurodegeneration. Besides their morbid association, gut bacteria metabolites are also found to play a significant role in reducing the onset of these life-threatening brain disorders.Studies done in the recent past raises two most important link between gut microbiota and the brain: gut microbiota-oxidative stress-neurodegeneration and gut microbiota-antioxidant-neuroprotection. This review aims to gives a deep insight to our readers, of the collective studies done, focusing on the gut microbiota mediated oxidative stress involved in neurodegeneration along with a focus on those studies showing the involvement of gut microbiota and their metabolites in neuroprotection.This review is focused on three main key concepts. Firstly, the mounting evidences from clinical and preclinical arenas shows the influence of gut microbiota mediated oxidative stress resulting in dysfunctional neurological processes. Therefore, we describe the potential role of gut microbiota influencing the vulnerability of brain to oxidative stress, and a budding causative in Alzheimer's and Parkinson's disease. Secondly, contributing roles of gut microbiota has been observed in attenuating oxidative stress and inflammation via its own metabolites or by producing secondary metabolites and, also modulation in gut microbiota population with antioxidative and anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput in silico tools and databases also gives a correlation of gut microbiome, their metabolites and brain health, thus providing fascinating perspective and promising new avenues for therapeutic options." @default.
• W3199156975 created "2021-09-27" @default.
• W3199156975 creator A5006548312 @default.
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• W3199156975 creator A5044840700 @default.
• W3199156975 creator A5049105214 @default.
• W3199156975 creator A5062567681 @default.
• W3199156975 date "2022-05-01" @default.
• W3199156975 modified "2023-10-17" @default.
• W3199156975 title "Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection" @default.
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