Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199178332> ?p ?o ?g. }
- W3199178332 abstract "Tissue engineered heart valves offer an exciting alternative to traditional valve prostheses. Methods of construction vary, from decellularised animal tissue to synthetic hydrogels, but the goal is the same: the creation of a ‘living valve’ populated with autologous cells that may persist indefinitely upon implantation. Previous failed attempts in humans have highlighted the difficulty in predicting how a novel heart valve will perform in vivo. The final hurdle in bringing these prostheses to market is understanding the immune reaction in the short and long term. In particular, the chronic remodelling of a tissue engineered implant by macrophages remains poorly understood. No silver bullet exists, rather researchers must draw upon a number of in vitro and in vivo models to fully elucidate the effect a host will exert on the graft. This review details the methods by which the immunogenicity of tissue engineered heart valves may be investigated and reveals areas that would benefit from more research." @default.
- W3199178332 created "2021-09-27" @default.
- W3199178332 creator A5026161080 @default.
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- W3199178332 creator A5059998667 @default.
- W3199178332 creator A5070452897 @default.
- W3199178332 creator A5087059388 @default.
- W3199178332 date "2021-01-01" @default.
- W3199178332 modified "2023-09-27" @default.
- W3199178332 title "Models of Immunogenicity in Preclinical Assessment of Tissue Engineered Heart Valves" @default.
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