FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199193362> ?p ?o ?g. }

• W3199193362 abstract "Congenital heart defects (CHDs) represent the most common human birth defects. Our previous study indicates that the malfunction of microRNAs (miRNAs) in cardiac neural crest cells (NCCs), which contribute to the development of the heart and the connected great vessels, is likely linked to the pathogenesis of human CHDs. In this study, we attempt to further search for causative single-nucleotide variants (SNVs) from CHD patients that mediate the mis-regulating of miRNAs on their downstream target genes in the pathogenesis of CHDs. As a result, a total of 2,925 3′UTR SNVs were detected from a CHD cohort. In parallel, we profiled the expression of miRNAs in cardiac NCCs and found 201 expressed miRNAs. A combined analysis with these data further identified three 3′UTR SNVs, including NFATC1 c. * 654C&gt;T, FGFRL1 c. * 414C&gt;T, and CTNNB1 c. * 729_ * 730insT, which result in the malfunction of miRNA-mediated gene regulation. The dysregulations were further validated experimentally. Therefore, our study indicates that miRNA-mediated gene dysregulation in cardiac NCCs could be an important etiology of congenital heart disease, which could lead to a new direction of diagnostic and therapeutic investigation on congenital heart disease." @default.
• W3199193362 created "2021-09-27" @default.
• W3199193362 creator A5015168523 @default.
• W3199193362 creator A5021598717 @default.
• W3199193362 creator A5041822883 @default.
• W3199193362 creator A5044183529 @default.
• W3199193362 creator A5045496557 @default.
• W3199193362 creator A5045814682 @default.
• W3199193362 creator A5053266740 @default.
• W3199193362 creator A5064488370 @default.
• W3199193362 creator A5076162565 @default.
• W3199193362 creator A5083670434 @default.
• W3199193362 date "2021-09-10" @default.
• W3199193362 modified "2023-10-14" @default.
• W3199193362 title "Identification of Novel Single-Nucleotide Variants With Potential of Mediating Malfunction of MicroRNA in Congenital Heart Disease" @default.
• W3199193362 cites W144423133 @default.
• W3199193362 cites W1488372279 @default.
• W3199193362 cites W1556057172 @default.
• W3199193362 cites W1585473102 @default.
• W3199193362 cites W1667206495 @default.
• W3199193362 cites W1984068087 @default.
• W3199193362 cites W1984798293 @default.
• W3199193362 cites W1986002337 @default.
• W3199193362 cites W1986903527 @default.
• W3199193362 cites W2001584235 @default.
• W3199193362 cites W2003426511 @default.
• W3199193362 cites W2026570544 @default.
• W3199193362 cites W2034806302 @default.
• W3199193362 cites W2047529648 @default.
• W3199193362 cites W2061278029 @default.
• W3199193362 cites W2062290101 @default.
• W3199193362 cites W2083381199 @default.
• W3199193362 cites W2093931321 @default.
• W3199193362 cites W2098304591 @default.
• W3199193362 cites W2102735467 @default.
• W3199193362 cites W2104010513 @default.
• W3199193362 cites W2125818518 @default.
• W3199193362 cites W2136187145 @default.
• W3199193362 cites W2142563181 @default.
• W3199193362 cites W2148037744 @default.
• W3199193362 cites W2151548507 @default.
• W3199193362 cites W2162347038 @default.
• W3199193362 cites W2171062983 @default.
• W3199193362 cites W2185661130 @default.
• W3199193362 cites W2588025094 @default.
• W3199193362 cites W2737530623 @default.
• W3199193362 cites W2898440040 @default.
• W3199193362 cites W2898598946 @default.
• W3199193362 cites W2915433652 @default.
• W3199193362 cites W2970358232 @default.
• W3199193362 doi "https://doi.org/10.3389/fcvm.2021.739598" @default.
• W3199193362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8460875" @default.
• W3199193362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34568467" @default.
• W3199193362 hasPublicationYear "2021" @default.
• W3199193362 type Work @default.
• W3199193362 sameAs 3199193362 @default.
• W3199193362 citedByCount "0" @default.
• W3199193362 crossrefType "journal-article" @default.
• W3199193362 hasAuthorship W3199193362A5015168523 @default.
• W3199193362 hasAuthorship W3199193362A5021598717 @default.
• W3199193362 hasAuthorship W3199193362A5041822883 @default.
• W3199193362 hasAuthorship W3199193362A5044183529 @default.
• W3199193362 hasAuthorship W3199193362A5045496557 @default.
• W3199193362 hasAuthorship W3199193362A5045814682 @default.
• W3199193362 hasAuthorship W3199193362A5053266740 @default.
• W3199193362 hasAuthorship W3199193362A5064488370 @default.
• W3199193362 hasAuthorship W3199193362A5076162565 @default.
• W3199193362 hasAuthorship W3199193362A5083670434 @default.
• W3199193362 hasBestOaLocation W31991933621 @default.
• W3199193362 hasConcept C104317684 @default.
• W3199193362 hasConcept C105580179 @default.
• W3199193362 hasConcept C135763542 @default.
• W3199193362 hasConcept C137627325 @default.
• W3199193362 hasConcept C142724271 @default.
• W3199193362 hasConcept C145059251 @default.
• W3199193362 hasConcept C145103041 @default.
• W3199193362 hasConcept C153209595 @default.
• W3199193362 hasConcept C2779134260 @default.
• W3199193362 hasConcept C2780074459 @default.
• W3199193362 hasConcept C2780942790 @default.
• W3199193362 hasConcept C54355233 @default.
• W3199193362 hasConcept C60644358 @default.
• W3199193362 hasConcept C62425271 @default.
• W3199193362 hasConcept C71924100 @default.
• W3199193362 hasConcept C86803240 @default.
• W3199193362 hasConcept C89604277 @default.
• W3199193362 hasConceptScore W3199193362C104317684 @default.
• W3199193362 hasConceptScore W3199193362C105580179 @default.
• W3199193362 hasConceptScore W3199193362C135763542 @default.
• W3199193362 hasConceptScore W3199193362C137627325 @default.
• W3199193362 hasConceptScore W3199193362C142724271 @default.
• W3199193362 hasConceptScore W3199193362C145059251 @default.
• W3199193362 hasConceptScore W3199193362C145103041 @default.
• W3199193362 hasConceptScore W3199193362C153209595 @default.
• W3199193362 hasConceptScore W3199193362C2779134260 @default.
• W3199193362 hasConceptScore W3199193362C2780074459 @default.
• W3199193362 hasConceptScore W3199193362C2780942790 @default.
• W3199193362 hasConceptScore W3199193362C54355233 @default.
• W3199193362 hasConceptScore W3199193362C60644358 @default.
• W3199193362 hasConceptScore W3199193362C62425271 @default.

• next