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• W3199193713 endingPage "130014" @default.
• W3199193713 startingPage "130014" @default.
• W3199193713 abstract "Drugs that modulate previously unexplored targets could potentially slow or halt the progression of neurodegenerative diseases. Several candidate proteins lie within the dark kinome, those human kinases that have not been well characterized. Much of the kinome (~80%) remains poorly studied, and these targets likely harbor untapped biological potential.This review highlights the significance of kinases as mediators of aberrant pathways in neurodegeneration and provides examples of published high-quality small molecules that modulate some of these kinases.There is a need for continued efforts to develop high-quality chemical tools to illuminate the function of understudied kinases in the brain. Potent and selective small molecules enable accurate pairing of an observed phenotype with a protein target.The examples discussed herein support the premise that validation of therapeutic hypotheses surrounding kinase targets can be accomplished via small molecules and they can serve as the basis for disease-focused drug development campaigns." @default.
• W3199193713 created "2021-09-27" @default.
• W3199193713 creator A5055004556 @default.
• W3199193713 date "2021-12-01" @default.
• W3199193713 modified "2023-09-25" @default.
• W3199193713 title "Characterizing the role of the dark kinome in neurodegenerative disease – A mini review" @default.
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