FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199200626> ?p ?o ?g. }

• W3199200626 abstract "Background: MAPK kinase kinase 8 (MAP3K8) is involved in the regulation of MAPK cascades and immune responses. Differential expression of MAP3K8 is closely correlated with tumorigenesis. In this study, we used bioinformatics tools to explore expression level, prognostic values, and interactive networks of MAP3K8 in renal clear cell carcinoma (ccRCC). Methods: Differential expression of MAP3K8 was determined by TIMER2.0, UALCAN, and Oncomine Platform. For exploration of MAP3K8 mutation profile, TIMER2.0, DriverDBv3, and cBioPortal were used. The survival module of GEPIA, UALCAN, and DriverDBv3 was used to examine the prognostic value of MAP3K8. Immune infiltration was estimated by TIMER, TIDE, CIBERSORT, CIBERSORT-ABS, QUANTISEQ, XCELL, MCPCOUNTER, and EPIC algorithms. PPI networks and functional enrichment analysis were constructed using GeneMANIA, Cytoscape, and Metascape. The co-expression module in cBioPortal was used to find genes that are correlated with MAP3K8 in mRNA expression. Results: Compared to normal renal samples, ccRCC (3.08-fold change, P = 1.50E-7; 1.10-fold change, P = 3.00E-3), papillary RCC (2.24-fold change, P = 1.86E-4), and hereditary ccRCC (1.98-fold change, P = 1.69E-9) have significantly higher levels of MAP3K8 expression. Compared to Grade 1 ccRCC samples, Grade 2 ( P = 1.28E-3) and Grade 3 ( P = 7.41E-4) cases have higher levels of MAP3K8 methylation. Percentage of patients harboring MAP3K8 mutation is 0.3% from TIMER2.0 and 0.2 to 11.5% from cBioPortal. High levels of MAP3K8 expression were associated with poorer overall survival (OS) in ccRCC (GEPIA: Log-rank P = 0.60E-2, HR = 1.5; DriverDBv3: Log-rank P = 1.68E-7, HR = 2.21; UALCAN: P = 0.20E-2). MAP3K8 was positively correlated with the presence of T cell regulatory (Tregs) (QUANTISEQ: Rho = 0.33, P = 1.59E-13). PPI network and functional enrichment analyses revealed that MAP3K8 correlated with NFKBIZ, MIAT, PARP15, CHFR, MKNK1, and ERMN, which was mainly involved in I-kappaB kinase/NF-kappaB and toll-like receptor signaling pathways. Conclusion: MAP3K8 overexpression was correlated with damaged survival in ccRC and may play a crucial role in cancer-related inflammation via I-kappaB kinase/NF-kappaB and toll-like receptor signaling pathways." @default.
• W3199200626 created "2021-09-27" @default.
• W3199200626 creator A5010120174 @default.
• W3199200626 creator A5013014678 @default.
• W3199200626 creator A5016044318 @default.
• W3199200626 creator A5022634072 @default.
• W3199200626 creator A5045953890 @default.
• W3199200626 creator A5088938513 @default.
• W3199200626 date "2021-09-10" @default.
• W3199200626 modified "2023-10-06" @default.
• W3199200626 title "Effect of MAP3K8 on Prognosis and Tumor-Related Inflammation in Renal Clear Cell Carcinoma" @default.
• W3199200626 cites W1909477108 @default.
• W3199200626 cites W1977918192 @default.
• W3199200626 cites W1985213868 @default.
• W3199200626 cites W1988597072 @default.
• W3199200626 cites W1999966467 @default.
• W3199200626 cites W2032261877 @default.
• W3199200626 cites W2046507292 @default.
• W3199200626 cites W2083829960 @default.
• W3199200626 cites W2084290127 @default.
• W3199200626 cites W2090362960 @default.
• W3199200626 cites W2092892924 @default.
• W3199200626 cites W2096172976 @default.
• W3199200626 cites W2110894217 @default.
• W3199200626 cites W2114843025 @default.
• W3199200626 cites W2118278569 @default.
• W3199200626 cites W2133123802 @default.
• W3199200626 cites W2134062610 @default.
• W3199200626 cites W2134887638 @default.
• W3199200626 cites W2141674733 @default.
• W3199200626 cites W2146838928 @default.
• W3199200626 cites W2149456801 @default.
• W3199200626 cites W2159675211 @default.
• W3199200626 cites W2160476851 @default.
• W3199200626 cites W2165738271 @default.
• W3199200626 cites W2222086386 @default.
• W3199200626 cites W2324000374 @default.
• W3199200626 cites W2335012284 @default.
• W3199200626 cites W2498858397 @default.
• W3199200626 cites W2590483199 @default.
• W3199200626 cites W2604761264 @default.
• W3199200626 cites W2607129810 @default.
• W3199200626 cites W2726542547 @default.
• W3199200626 cites W2736730167 @default.
• W3199200626 cites W2758279115 @default.
• W3199200626 cites W2765953690 @default.
• W3199200626 cites W2792937256 @default.
• W3199200626 cites W2911188335 @default.
• W3199200626 cites W2917524635 @default.
• W3199200626 cites W2919716556 @default.
• W3199200626 cites W2920587676 @default.
• W3199200626 cites W2928665623 @default.
• W3199200626 cites W2952383255 @default.
• W3199200626 cites W2982051641 @default.
• W3199200626 cites W2985613549 @default.
• W3199200626 cites W3027286012 @default.
• W3199200626 cites W3044762217 @default.
• W3199200626 cites W3049642946 @default.
• W3199200626 cites W3097136888 @default.
• W3199200626 cites W4237816489 @default.
• W3199200626 cites W4246839070 @default.
• W3199200626 doi "https://doi.org/10.3389/fgene.2021.674613" @default.
• W3199200626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8461076" @default.
• W3199200626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34567061" @default.
• W3199200626 hasPublicationYear "2021" @default.
• W3199200626 type Work @default.
• W3199200626 sameAs 3199200626 @default.
• W3199200626 citedByCount "6" @default.
• W3199200626 countsByYear W31992006262022 @default.
• W3199200626 countsByYear W31992006262023 @default.
• W3199200626 crossrefType "journal-article" @default.
• W3199200626 hasAuthorship W3199200626A5010120174 @default.
• W3199200626 hasAuthorship W3199200626A5013014678 @default.
• W3199200626 hasAuthorship W3199200626A5016044318 @default.
• W3199200626 hasAuthorship W3199200626A5022634072 @default.
• W3199200626 hasAuthorship W3199200626A5045953890 @default.
• W3199200626 hasAuthorship W3199200626A5088938513 @default.
• W3199200626 hasBestOaLocation W31992006261 @default.
• W3199200626 hasConcept C104317684 @default.
• W3199200626 hasConcept C126322002 @default.
• W3199200626 hasConcept C2777472916 @default.
• W3199200626 hasConcept C2781278892 @default.
• W3199200626 hasConcept C502942594 @default.
• W3199200626 hasConcept C54355233 @default.
• W3199200626 hasConcept C555283112 @default.
• W3199200626 hasConcept C71924100 @default.
• W3199200626 hasConcept C86803240 @default.
• W3199200626 hasConceptScore W3199200626C104317684 @default.
• W3199200626 hasConceptScore W3199200626C126322002 @default.
• W3199200626 hasConceptScore W3199200626C2777472916 @default.
• W3199200626 hasConceptScore W3199200626C2781278892 @default.
• W3199200626 hasConceptScore W3199200626C502942594 @default.
• W3199200626 hasConceptScore W3199200626C54355233 @default.
• W3199200626 hasConceptScore W3199200626C555283112 @default.
• W3199200626 hasConceptScore W3199200626C71924100 @default.
• W3199200626 hasConceptScore W3199200626C86803240 @default.
• W3199200626 hasLocation W31992006261 @default.
• W3199200626 hasLocation W31992006262 @default.
• W3199200626 hasLocation W31992006263 @default.
• W3199200626 hasLocation W31992006264 @default.

• next