FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199207908> ?p ?o ?g. }

• W3199207908 abstract "The World Health Organization has declared the outbreak of a novel coronavirus (SARS-CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the coronavirus infection are not yet fully understand, nor are there any targeted treatments or vaccines. In this study, we identified high-binding-affinity aptamers targeting SARS-CoV-2 RBD, using an ACE2 competition-based aptamer selection strategy and a machine learning screening algorithm. The K d values of the optimized CoV2-RBD-1C and CoV2-RBD-4C aptamers against RBD were 5.8 nM and 19.9 nM, respectively. Simulated interaction modeling, along with competitive with experiments, suggests that two aptamers may have partially identical binding sites at ACE2 on SARS-CoV-2 RBD. These aptamers present an opportunity for generating new probes for recognition of SARS-CoV-2, and could provide assistance in the diagnosis and treatment of SARS-CoV-2 while providing a new tool for in-depth study of the mechanisms behind the coronavirus infection." @default.
• W3199207908 created "2021-09-27" @default.
• W3199207908 creator A5006349996 @default.
• W3199207908 creator A5008386803 @default.
• W3199207908 creator A5021973607 @default.
• W3199207908 creator A5025814275 @default.
• W3199207908 creator A5028607720 @default.
• W3199207908 creator A5049740688 @default.
• W3199207908 creator A5062036273 @default.
• W3199207908 creator A5072097085 @default.
• W3199207908 creator A5073050892 @default.
• W3199207908 creator A5076637841 @default.
• W3199207908 date "2020-04-01" @default.
• W3199207908 modified "2023-10-01" @default.
• W3199207908 title "Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein" @default.
• W3199207908 cites W181533737 @default.
• W3199207908 cites W1843578997 @default.
• W3199207908 cites W1889888568 @default.
• W3199207908 cites W1984335993 @default.
• W3199207908 cites W1985618132 @default.
• W3199207908 cites W1986377047 @default.
• W3199207908 cites W2002938719 @default.
• W3199207908 cites W2004208437 @default.
• W3199207908 cites W2021468558 @default.
• W3199207908 cites W2034438385 @default.
• W3199207908 cites W2040287433 @default.
• W3199207908 cites W2047381373 @default.
• W3199207908 cites W2064824312 @default.
• W3199207908 cites W2064850047 @default.
• W3199207908 cites W2074118639 @default.
• W3199207908 cites W2082755732 @default.
• W3199207908 cites W2084515141 @default.
• W3199207908 cites W2085499708 @default.
• W3199207908 cites W2100038386 @default.
• W3199207908 cites W2106483552 @default.
• W3199207908 cites W2112557236 @default.
• W3199207908 cites W2129667078 @default.
• W3199207908 cites W2137144526 @default.
• W3199207908 cites W2140742786 @default.
• W3199207908 cites W2152303682 @default.
• W3199207908 cites W2153465289 @default.
• W3199207908 cites W2180848504 @default.
• W3199207908 cites W2408207015 @default.
• W3199207908 cites W2470646526 @default.
• W3199207908 cites W2584748551 @default.
• W3199207908 cites W2796759435 @default.
• W3199207908 cites W2888366784 @default.
• W3199207908 cites W2894850335 @default.
• W3199207908 cites W2902727140 @default.
• W3199207908 cites W2982453601 @default.
• W3199207908 cites W3002539152 @default.
• W3199207908 cites W24060287 @default.
• W3199207908 doi "https://doi.org/10.26434/chemrxiv.12053535.v1" @default.
• W3199207908 hasPublicationYear "2020" @default.
• W3199207908 type Work @default.
• W3199207908 sameAs 3199207908 @default.
• W3199207908 citedByCount "0" @default.
• W3199207908 crossrefType "posted-content" @default.
• W3199207908 hasAuthorship W3199207908A5006349996 @default.
• W3199207908 hasAuthorship W3199207908A5008386803 @default.
• W3199207908 hasAuthorship W3199207908A5021973607 @default.
• W3199207908 hasAuthorship W3199207908A5025814275 @default.
• W3199207908 hasAuthorship W3199207908A5028607720 @default.
• W3199207908 hasAuthorship W3199207908A5049740688 @default.
• W3199207908 hasAuthorship W3199207908A5062036273 @default.
• W3199207908 hasAuthorship W3199207908A5072097085 @default.
• W3199207908 hasAuthorship W3199207908A5073050892 @default.
• W3199207908 hasAuthorship W3199207908A5076637841 @default.
• W3199207908 hasBestOaLocation W31992079081 @default.
• W3199207908 hasConcept C108625454 @default.
• W3199207908 hasConcept C116675565 @default.
• W3199207908 hasConcept C128972844 @default.
• W3199207908 hasConcept C142724271 @default.
• W3199207908 hasConcept C159047783 @default.
• W3199207908 hasConcept C2777648638 @default.
• W3199207908 hasConcept C2779134260 @default.
• W3199207908 hasConcept C3006700255 @default.
• W3199207908 hasConcept C3007834351 @default.
• W3199207908 hasConcept C3008058167 @default.
• W3199207908 hasConcept C524204448 @default.
• W3199207908 hasConcept C54355233 @default.
• W3199207908 hasConcept C70721500 @default.
• W3199207908 hasConcept C71924100 @default.
• W3199207908 hasConcept C86803240 @default.
• W3199207908 hasConcept C89623803 @default.
• W3199207908 hasConceptScore W3199207908C108625454 @default.
• W3199207908 hasConceptScore W3199207908C116675565 @default.
• W3199207908 hasConceptScore W3199207908C128972844 @default.
• W3199207908 hasConceptScore W3199207908C142724271 @default.
• W3199207908 hasConceptScore W3199207908C159047783 @default.
• W3199207908 hasConceptScore W3199207908C2777648638 @default.
• W3199207908 hasConceptScore W3199207908C2779134260 @default.
• W3199207908 hasConceptScore W3199207908C3006700255 @default.
• W3199207908 hasConceptScore W3199207908C3007834351 @default.
• W3199207908 hasConceptScore W3199207908C3008058167 @default.
• W3199207908 hasConceptScore W3199207908C524204448 @default.
• W3199207908 hasConceptScore W3199207908C54355233 @default.
• W3199207908 hasConceptScore W3199207908C70721500 @default.
• W3199207908 hasConceptScore W3199207908C71924100 @default.
• W3199207908 hasConceptScore W3199207908C86803240 @default.

• next