Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199207936> ?p ?o ?g. }
- W3199207936 endingPage "9783" @default.
- W3199207936 startingPage "9783" @default.
- W3199207936 abstract "Prostate cancer (PC) is the second most common cancer in men worldwide. Due to the large-scale sequencing efforts, there is currently a better understanding of the genomic landscape of PC. The identification of defects in DNA repair genes has led to clinical studies that provide a strong rationale for developing poly (ADP-ribose) polymerase (PARP) inhibitors and DNA-damaging agents in this molecularly defined subset of patients. The identification of molecularly defined subgroups of patients has also other clinical implications; for example, we now know that carriers of breast cancer 2 (BRCA2) pathogenic sequence variants (PSVs) have increased levels of serum prostate specific antigen (PSA) at diagnosis, increased proportion of high Gleason tumors, elevated rates of nodal and distant metastases, and high recurrence rate; BRCA2 PSVs confer lower overall survival (OS). Distinct tumor PSV, methylation, and expression patterns have been identified in BRCA2 compared with non-BRCA2 mutant prostate tumors. Several DNA damage response and repair (DDR)-targeting agents are currently being evaluated either as single agents or in combination in patients with PC. In this review article, we highlight the biology and clinical implications of deleterious inherited or acquired DNA repair pathway aberrations in PC and offer an overview of new agents being developed for the treatment of PC." @default.
- W3199207936 created "2021-09-27" @default.
- W3199207936 creator A5016163128 @default.
- W3199207936 creator A5057565228 @default.
- W3199207936 creator A5059600322 @default.
- W3199207936 creator A5059943491 @default.
- W3199207936 creator A5084117294 @default.
- W3199207936 date "2021-09-10" @default.
- W3199207936 modified "2023-10-16" @default.
- W3199207936 title "Genetic Aberrations of DNA Repair Pathways in Prostate Cancer: Translation to the Clinic" @default.
- W3199207936 cites W1578291413 @default.
- W3199207936 cites W1816802498 @default.
- W3199207936 cites W2087481500 @default.
- W3199207936 cites W2111437716 @default.
- W3199207936 cites W2128659368 @default.
- W3199207936 cites W2142096492 @default.
- W3199207936 cites W2161112598 @default.
- W3199207936 cites W2235405584 @default.
- W3199207936 cites W2405114290 @default.
- W3199207936 cites W2462985846 @default.
- W3199207936 cites W2510940971 @default.
- W3199207936 cites W2531934133 @default.
- W3199207936 cites W2597062310 @default.
- W3199207936 cites W2600861426 @default.
- W3199207936 cites W2604876648 @default.
- W3199207936 cites W2607665721 @default.
- W3199207936 cites W2608211931 @default.
- W3199207936 cites W2620706965 @default.
- W3199207936 cites W2626902876 @default.
- W3199207936 cites W2725414935 @default.
- W3199207936 cites W2767883250 @default.
- W3199207936 cites W2789730857 @default.
- W3199207936 cites W2806421431 @default.
- W3199207936 cites W2808021061 @default.
- W3199207936 cites W2808919129 @default.
- W3199207936 cites W2887136529 @default.
- W3199207936 cites W2891475975 @default.
- W3199207936 cites W2908857416 @default.
- W3199207936 cites W2915944698 @default.
- W3199207936 cites W2962675576 @default.
- W3199207936 cites W2977585001 @default.
- W3199207936 cites W2979840360 @default.
- W3199207936 cites W2981585441 @default.
- W3199207936 cites W2989894179 @default.
- W3199207936 cites W2990053395 @default.
- W3199207936 cites W2990771207 @default.
- W3199207936 cites W3008060424 @default.
- W3199207936 cites W3008168317 @default.
- W3199207936 cites W3008542548 @default.
- W3199207936 cites W3013350468 @default.
- W3199207936 cites W3013665199 @default.
- W3199207936 cites W3013755340 @default.
- W3199207936 cites W3016210627 @default.
- W3199207936 cites W3016483659 @default.
- W3199207936 cites W3020145119 @default.
- W3199207936 cites W3020771563 @default.
- W3199207936 cites W3033920919 @default.
- W3199207936 cites W3036860998 @default.
- W3199207936 cites W3041411798 @default.
- W3199207936 cites W3046361694 @default.
- W3199207936 cites W3080458669 @default.
- W3199207936 cites W3082841288 @default.
- W3199207936 cites W3083447616 @default.
- W3199207936 cites W3083951977 @default.
- W3199207936 cites W3084418387 @default.
- W3199207936 cites W3088242837 @default.
- W3199207936 cites W3089738108 @default.
- W3199207936 cites W3094420338 @default.
- W3199207936 cites W3165176963 @default.
- W3199207936 cites W3181587133 @default.
- W3199207936 cites W3191534679 @default.
- W3199207936 cites W4238923775 @default.
- W3199207936 doi "https://doi.org/10.3390/ijms22189783" @default.
- W3199207936 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8471942" @default.
- W3199207936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34575947" @default.
- W3199207936 hasPublicationYear "2021" @default.
- W3199207936 type Work @default.
- W3199207936 sameAs 3199207936 @default.
- W3199207936 citedByCount "34" @default.
- W3199207936 countsByYear W31992079362021 @default.
- W3199207936 countsByYear W31992079362022 @default.
- W3199207936 countsByYear W31992079362023 @default.
- W3199207936 crossrefType "journal-article" @default.
- W3199207936 hasAuthorship W3199207936A5016163128 @default.
- W3199207936 hasAuthorship W3199207936A5057565228 @default.
- W3199207936 hasAuthorship W3199207936A5059600322 @default.
- W3199207936 hasAuthorship W3199207936A5059943491 @default.
- W3199207936 hasAuthorship W3199207936A5084117294 @default.
- W3199207936 hasBestOaLocation W31992079361 @default.
- W3199207936 hasConcept C104317684 @default.
- W3199207936 hasConcept C121608353 @default.
- W3199207936 hasConcept C126322002 @default.
- W3199207936 hasConcept C134935766 @default.
- W3199207936 hasConcept C143425029 @default.
- W3199207936 hasConcept C143998085 @default.
- W3199207936 hasConcept C182979987 @default.
- W3199207936 hasConcept C2776235491 @default.
- W3199207936 hasConcept C2778502085 @default.