FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199212539> ?p ?o ?g. }

• W3199212539 abstract "Ubiquilin‑1 (UBQLN1) is an essential factor for the maintenance of proteostasis in cells. It is important for the regulation of different protein degradation mechanisms, including the ubiquitin‑proteasome system, autophagy and endoplasmic reticulum‑associated protein degradation pathways. However, the role of UBQLN1 in cancer progression remains largely unknown. In the present study, the expression, functions and molecular mechanisms of UBQLN1 in breast cancer tissue samples and cell lines were explored. Immunohistochemical and bioinformatics analyses revealed that UBQLN1 expression was significantly upregulated in breast cancer tissues and cell lines. UBQLN1 expression in breast cancer was significantly associated with lymph node metastasis and TNM stage. Moreover, a high UBQLN1 expression was a predictor of an unfavorable survival in patients with breast cancer. <em>In vitro</em>, UBQLN1 silencing markedly inhibited cell migration and invasion, epithelial‑to‑mesenchymal transition (EMT) and MMP expression. UBQLN1 silencing attenuated the stem cell‑like properties of breast cancer cells, including their mammosphere‑forming abilities. UBQLN1 knockdown also enhanced breast cancer cell chemosensitivity to paclitaxel. The expression levels of the stem cell markers. Aldehyde dehydrogenase 1 (ALDH1), Oct‑4 and Sox2 were significantly decreased in the cells in which UBQLN1 was silenced, whereas breast cancer stem cells exhibited an increased expression of UBQLN1. Mechanistically, UBQLN1 knockdown inhibited the activation of AKT signaling, as revealed by the increased PTEN expression and the decreased expression of phosphorylated AKT in cells in which UBQLN1 was silenced. On the whole, the present study demonstrates that UBQLN1 is aberrantly upregulated in breast cancer and predicts a poor prognosis. The silencing of UBQLN1 inhibited the invasion, EMT and stemness of breast cancer cells, possibly via AKT signaling." @default.
• W3199212539 created "2021-09-27" @default.
• W3199212539 creator A5016164646 @default.
• W3199212539 creator A5030873204 @default.
• W3199212539 creator A5031612412 @default.
• W3199212539 creator A5035445599 @default.
• W3199212539 creator A5052886594 @default.
• W3199212539 creator A5061541496 @default.
• W3199212539 creator A5063446205 @default.
• W3199212539 creator A5071687930 @default.
• W3199212539 creator A5080570416 @default.
• W3199212539 date "2021-09-15" @default.
• W3199212539 modified "2023-10-10" @default.
• W3199212539 title "Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling" @default.
• W3199212539 cites W1927807537 @default.
• W3199212539 cites W1963501822 @default.
• W3199212539 cites W1969825737 @default.
• W3199212539 cites W1976379645 @default.
• W3199212539 cites W2014171837 @default.
• W3199212539 cites W2017555329 @default.
• W3199212539 cites W2027191947 @default.
• W3199212539 cites W2031217161 @default.
• W3199212539 cites W2033795441 @default.
• W3199212539 cites W2046511938 @default.
• W3199212539 cites W2047646614 @default.
• W3199212539 cites W2049413078 @default.
• W3199212539 cites W2060200458 @default.
• W3199212539 cites W2082803657 @default.
• W3199212539 cites W2083829020 @default.
• W3199212539 cites W2085934079 @default.
• W3199212539 cites W2095659495 @default.
• W3199212539 cites W2107277218 @default.
• W3199212539 cites W2108593484 @default.
• W3199212539 cites W2108881627 @default.
• W3199212539 cites W2114028154 @default.
• W3199212539 cites W2115452399 @default.
• W3199212539 cites W2133627399 @default.
• W3199212539 cites W2579676443 @default.
• W3199212539 cites W2734957653 @default.
• W3199212539 cites W2755027781 @default.
• W3199212539 cites W2765894460 @default.
• W3199212539 cites W2766437957 @default.
• W3199212539 cites W2774409422 @default.
• W3199212539 cites W2786843484 @default.
• W3199212539 cites W2901725551 @default.
• W3199212539 cites W2902072367 @default.
• W3199212539 cites W2903475296 @default.
• W3199212539 cites W2967026559 @default.
• W3199212539 cites W2979568652 @default.
• W3199212539 cites W2990283276 @default.
• W3199212539 cites W2991274658 @default.
• W3199212539 cites W2996626242 @default.
• W3199212539 cites W3027961446 @default.
• W3199212539 cites W3034324291 @default.
• W3199212539 cites W3037640271 @default.
• W3199212539 cites W3046028746 @default.
• W3199212539 cites W3082086623 @default.
• W3199212539 cites W3099901020 @default.
• W3199212539 cites W3103758115 @default.
• W3199212539 cites W3119105383 @default.
• W3199212539 cites W3128646645 @default.
• W3199212539 cites W3135882325 @default.
• W3199212539 cites W3155195291 @default.
• W3199212539 doi "https://doi.org/10.3892/or.2021.8187" @default.
• W3199212539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8453688" @default.
• W3199212539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34528694" @default.
• W3199212539 hasPublicationYear "2021" @default.
• W3199212539 type Work @default.
• W3199212539 sameAs 3199212539 @default.
• W3199212539 citedByCount "4" @default.
• W3199212539 countsByYear W31992125392022 @default.
• W3199212539 countsByYear W31992125392023 @default.
• W3199212539 crossrefType "journal-article" @default.
• W3199212539 hasAuthorship W3199212539A5016164646 @default.
• W3199212539 hasAuthorship W3199212539A5030873204 @default.
• W3199212539 hasAuthorship W3199212539A5031612412 @default.
• W3199212539 hasAuthorship W3199212539A5035445599 @default.
• W3199212539 hasAuthorship W3199212539A5052886594 @default.
• W3199212539 hasAuthorship W3199212539A5061541496 @default.
• W3199212539 hasAuthorship W3199212539A5063446205 @default.
• W3199212539 hasAuthorship W3199212539A5071687930 @default.
• W3199212539 hasAuthorship W3199212539A5080570416 @default.
• W3199212539 hasBestOaLocation W31992125391 @default.
• W3199212539 hasConcept C104317684 @default.
• W3199212539 hasConcept C119056186 @default.
• W3199212539 hasConcept C121608353 @default.
• W3199212539 hasConcept C173396325 @default.
• W3199212539 hasConcept C502942594 @default.
• W3199212539 hasConcept C530470458 @default.
• W3199212539 hasConcept C54355233 @default.
• W3199212539 hasConcept C55493867 @default.
• W3199212539 hasConcept C81885089 @default.
• W3199212539 hasConcept C86803240 @default.
• W3199212539 hasConceptScore W3199212539C104317684 @default.
• W3199212539 hasConceptScore W3199212539C119056186 @default.
• W3199212539 hasConceptScore W3199212539C121608353 @default.
• W3199212539 hasConceptScore W3199212539C173396325 @default.
• W3199212539 hasConceptScore W3199212539C502942594 @default.
• W3199212539 hasConceptScore W3199212539C530470458 @default.
• W3199212539 hasConceptScore W3199212539C54355233 @default.

• next