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• W3199251326 endingPage "136261" @default.
• W3199251326 startingPage "136261" @default.
• W3199251326 abstract "The ability to generate new hippocampal neurons throughout adulthood and successfully integrate them into existing neural networks is critical to cognitive function, while disordered regulation of this process results in neurodegenerative or psychiatric disease. Consequently, identifying the molecular mechanisms promoting homeostatic hippocampal neurogenesis in adults is essential to understanding the etiologies of these disorders and developing therapeutic interventions. For example, recent evidence identifies a strong association between metabolic function and adult hippocampal neurogenesis. Hippocampal neural stem cell (NSC) fate dynamically fluctuates with changes in substrate availability and energy status (AMP/ATP and NAD+/NADH ratios). Furthermore, many metabolic hormones, such as insulin, insulin-like growth factors, and leptin exhibit dual functions also modulating hippocampal neurogenesis and neuron survivability. These diverse metabolic inputs to NSC's from various tissues seemingly suggest the existence of a system in which energy status can finely modulate hippocampal neurogenesis. Supporting this hypothesis, interventions promoting energy balance, such as caloric restriction, intermittent fasting, and exercise, have shown encouraging potential enhancing hippocampal neurogenesis and cognitive function. Overall, there is a clear relationship between whole body energy status, adult hippocampal neurogenesis, and neuron survival; however, the molecular mechanisms underlying this phenomenon are multifaceted. Thus, the aim of this review is to analyze the literature investigating energy status-mediated regulation of adult neurogenesis in the hippocampus, highlight the neurocircuitry and intracellular signaling involved, and propose impactful future directions in the field." @default.
• W3199251326 created "2021-09-27" @default.
• W3199251326 creator A5044108510 @default.
• W3199251326 creator A5057025393 @default.
• W3199251326 date "2021-11-01" @default.
• W3199251326 modified "2023-09-29" @default.
• W3199251326 title "Mini review: The relationship between energy status and adult hippocampal neurogenesis" @default.
• W3199251326 cites W1488940119 @default.
• W3199251326 cites W1541929773 @default.
• W3199251326 cites W1593725384 @default.
• W3199251326 cites W1604789859 @default.
• W3199251326 cites W1642619469 @default.
• W3199251326 cites W1717443879 @default.
• W3199251326 cites W1874466506 @default.
• W3199251326 cites W1963940970 @default.
• W3199251326 cites W1965177877 @default.
• W3199251326 cites W1965263019 @default.
• W3199251326 cites W1968151995 @default.
• W3199251326 cites W1970351839 @default.
• W3199251326 cites W1971281741 @default.
• W3199251326 cites W1972862259 @default.
• W3199251326 cites W1973162109 @default.
• W3199251326 cites W1974470246 @default.
• W3199251326 cites W1975959567 @default.
• W3199251326 cites W1976212770 @default.
• W3199251326 cites W1977311786 @default.
• W3199251326 cites W1979424814 @default.
• W3199251326 cites W1984551681 @default.
• W3199251326 cites W1987400696 @default.
• W3199251326 cites W1987925748 @default.
• W3199251326 cites W1988869372 @default.
• W3199251326 cites W1989164058 @default.
• W3199251326 cites W1989290237 @default.
• W3199251326 cites W1990161015 @default.
• W3199251326 cites W1993088678 @default.
• W3199251326 cites W1993711393 @default.
• W3199251326 cites W1995188451 @default.
• W3199251326 cites W1996175687 @default.
• W3199251326 cites W2000265708 @default.
• W3199251326 cites W2002112050 @default.
• W3199251326 cites W2002161951 @default.
• W3199251326 cites W2003982930 @default.
• W3199251326 cites W2012403948 @default.
• W3199251326 cites W2012730798 @default.
• W3199251326 cites W2013451725 @default.
• W3199251326 cites W2015908426 @default.
• W3199251326 cites W2016500868 @default.
• W3199251326 cites W2019986565 @default.
• W3199251326 cites W2020895118 @default.
• W3199251326 cites W2021044023 @default.
• W3199251326 cites W2021551531 @default.
• W3199251326 cites W2024333143 @default.
• W3199251326 cites W2024954156 @default.
• W3199251326 cites W2026222662 @default.
• W3199251326 cites W2026393786 @default.
• W3199251326 cites W2028998458 @default.
• W3199251326 cites W2034604831 @default.
• W3199251326 cites W2034648042 @default.
• W3199251326 cites W2035653659 @default.
• W3199251326 cites W2036234078 @default.
• W3199251326 cites W2036860335 @default.
• W3199251326 cites W2041749675 @default.
• W3199251326 cites W2044015546 @default.
• W3199251326 cites W2044176668 @default.
• W3199251326 cites W2044185435 @default.
• W3199251326 cites W2045948521 @default.
• W3199251326 cites W2051393353 @default.
• W3199251326 cites W2052572393 @default.
• W3199251326 cites W2053298975 @default.
• W3199251326 cites W2057386575 @default.
• W3199251326 cites W2057608998 @default.
• W3199251326 cites W2058092187 @default.
• W3199251326 cites W2059937523 @default.
• W3199251326 cites W2060335478 @default.
• W3199251326 cites W2061169091 @default.
• W3199251326 cites W2063663360 @default.
• W3199251326 cites W2064484411 @default.
• W3199251326 cites W2067856703 @default.
• W3199251326 cites W2069072617 @default.
• W3199251326 cites W2069785065 @default.
• W3199251326 cites W2069833326 @default.
• W3199251326 cites W2073054617 @default.
• W3199251326 cites W2075431487 @default.
• W3199251326 cites W2076975132 @default.
• W3199251326 cites W2077033935 @default.
• W3199251326 cites W2077445047 @default.
• W3199251326 cites W2079338662 @default.
• W3199251326 cites W2079562282 @default.
• W3199251326 cites W2080692887 @default.
• W3199251326 cites W2080818732 @default.
• W3199251326 cites W2085655953 @default.
• W3199251326 cites W2086679674 @default.
• W3199251326 cites W2087133453 @default.
• W3199251326 cites W2087277393 @default.
• W3199251326 cites W2091273311 @default.
• W3199251326 cites W2091927578 @default.
• W3199251326 cites W2102535456 @default.
• W3199251326 cites W2104551938 @default.

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