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• W3199263602 abstract "To evaluate the association between pre-treatment maternal body mass index (BMI) and live birth rate (LBR) in patients undergoing fresh IVF-ET using autologous oocytes. A retrospective cohort study using SARTCORS database in women undergoing first IVF treatment using autologous oocytes (n=94,017) from January 2014 through December 2015 resulting in a fresh ET. Women of (mean [SD] age, 34.0 [4.47] and mean [SD] AMH, 2.28 [3.46]) underwent a fresh IVF-ET (n=47,326). The LBR after combined analysis was 44.4 %. In a combined analysis, there was a decreasing trend of LBR in all BMI categories outside 18.5-24.9 (referent). The adjusted OR (95% CI) of LBR for women with BMI ≤17.5, 17.5-18.49, 25-29.9, 30-34.9, 35-39.9, 40-44.9 and ≥ 45, compared to referent was 0.97 (0.84-1.12), 0.86 (0.83-0.9), 0.77 (0.73-0.82), 0.71 (0.65-0.76), 0.59 (0.52-0.67), 0.92 (0.75-1.14) and 0.51 (0.42-0.63) respectively. A similar, decreasing trend in LBR was observed for implantation rate (IR) and clinical pregnancy rate (CPR) in all BMI categories outside referent in women with a blastocyst ET. The AOR for reproductive outcomes for blastocyst ET (n=32,115) are shown in Table 1.Tabled 1Table 1Maternal BMI (kg/m2)ReproductiveOutcome≤17.517.5-18.4918.5-24.925-29.930-34.935-39.940-44.9≥45Clinical Pregnancy Rate1 (0.83-1.19)0.86 (0.82-0.91)Ref0.84 (0.78-0.9)0.77 (0.7-0.84)0.72 (0.61-0.84)0.87 (0.68-1.13)0.58 (0.45-0.75)Implantation Rate0.96 (0.86-1.07)0.89 (0.86-0.92)Ref0.84 (0.8-0.88)0.8 (0.75-0.85)0.76 (0.68-0.86)1.09 (0.94-1.26)0.64 (0.52-0.8)Reproductive outcomes based on individual treatment protocol, showed a similar trend. The AOR for treatment protocols are shown in Table 2. Open table in a new tab Tabled 1Table 2Maternal BMI (kg/m2)VariablesCategories≤17.517.5-18.4918.5-24.925-29.930-34.935-39.940-44.9≥45TreatmentProtocolAgonist1.24 (0.94-1.64)0.8 (0.73-0.87)Ref0.75 (0.67-0.83)0.68 (0.58-0.79)0.5 (0.39-0.64)1.07 (0.7-1.61)0.53 (0.36-0.76)Antagonist0.86 (0.72-1.03)0.89 (0.84- 0.94)Ref0.8 (0.74-0.85)0.71 (0.65-0.78)0.63 (0.54-0.74)0.89 (0.68-1.15)0.48 (0.37-0.62)Subgroup analysis showed that extremes of BMI was a negative predictor for LBR in women based on the number of oocytes, stage of embryos, the number of embryos transferred, and type of insemination. Open table in a new tab Reproductive outcomes based on individual treatment protocol, showed a similar trend. The AOR for treatment protocols are shown in Table 2. Subgroup analysis showed that extremes of BMI was a negative predictor for LBR in women based on the number of oocytes, stage of embryos, the number of embryos transferred, and type of insemination. In this large, nationwide cohort study in women with a fresh IVF-ET extremes of pre-treatment maternal BMI was a significant negative predictor for IVF outcomes." @default.
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• W3199263602 date "2021-09-01" @default.
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• W3199263602 title "ASSOCIATION BETWEEN PRE-TREATMENT MATERNAL BODY MASS INDEX AND REPRODUCTIVE OUTCOMES: AN ANALYSIS OF > 45,000 FRESH, AUTOLOGOUS IVF TREATMENT CYCLES FROM SARTCORS DATABASE" @default.
• W3199263602 doi "https://doi.org/10.1016/j.fertnstert.2021.07.657" @default.
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