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• W3199265087 endingPage "125978" @default.
• W3199265087 startingPage "125978" @default.
• W3199265087 abstract "Acetyl-CoA is a kind of important cofactor that is involved in many metabolic pathways. It serves as the precursor for many interesting commercial products, such as terpenes, flavonoids and anthraquinones. However, the insufficient supply of acetyl-CoA limits biosynthesis of its derived compounds in the intracellular. In this review, we outlined metabolic pathways involved in the catabolism and anabolism of acetyl-CoA, as well as some important derived products. We examined several strategies for the enhanced supply of acetyl-CoA, and provided insight into pathways that generate acetyl-CoA to balance metabolism, which can be harnessed to improve the titer, yield and productivities of interesting products in Saccharomyces cerevisiae and other eukaryotic microorganisms. We believe that peroxisomal fatty acid β-oxidation could be an attractive strategy for enhancing the supply of acetyl-CoA." @default.
• W3199265087 created "2021-09-27" @default.
• W3199265087 creator A5007575202 @default.
• W3199265087 creator A5011448167 @default.
• W3199265087 creator A5032984799 @default.
• W3199265087 creator A5072416001 @default.
• W3199265087 date "2021-12-01" @default.
• W3199265087 modified "2023-10-18" @default.
• W3199265087 title "Metabolism and strategies for enhanced supply of acetyl-CoA in Saccharomyces cerevisiae" @default.
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