Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199281570> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W3199281570 endingPage "1137" @default.
- W3199281570 startingPage "1126" @default.
- W3199281570 abstract "Hyperbaric oxygen (HBO2) inhibits the GABAergic function in the brain, which leads to the development of convulsive reactions in the form of paroxysmal discharges on the EEG and movement disorders, similar to a generalized epileptic seizure. We hypothesize that the deficiency of GABAergic neurotransmission in HBO2, which occurs due to suppression of GABA synthesis, can be overcome by blocking the clearance of GABA from the synaptic cleft and slowing down its enzymatic degradation. The present study is aimed at studying the development of seizure reactions in rats under oxygen pressure of 5 ATA after blockade of GABA transporters with tiagabine and inhibition of GABA-transaminase with vigabatrin. New data obtained in this study are: (1) inhibition of GABA transaminase by vigabatrin or GABA transporters by tiagabine prevented the development of seizures in rats under oxygen pressure of 5 ATA; (2) oxygen convulsions in HBO2 appeared with a decrease in the brain GABA by 30-40% from the initial level; (3) inhibition of GABA transaminase by vigabatrin prevented a decrease in GABA in the striatum of rats under 5 ATA pressure. Consequently, a slowdown in synaptic clearance of GABA or a weakening of the enzymatic destruction of a mediator can compensate reduced GABA synthesis in HBO2 and increase its concentration to a level sufficient for the restoration of GABAergic function preventing the development of convulsive syndrome." @default.
- W3199281570 created "2021-09-27" @default.
- W3199281570 creator A5013126161 @default.
- W3199281570 creator A5032153642 @default.
- W3199281570 creator A5041637547 @default.
- W3199281570 creator A5045685247 @default.
- W3199281570 creator A5091912184 @default.
- W3199281570 date "2021-01-01" @default.
- W3199281570 modified "2023-10-18" @default.
- W3199281570 title "Ингибирование ГАМК-трансаминазы и ГАМК-транспортеров в головном мозге с помощью вигабатрина и тиагабина ослабляет развитие судорог у крыс при дыхании гипербарическим кислородом" @default.
- W3199281570 doi "https://doi.org/10.31857/s0869813921090041" @default.
- W3199281570 hasPublicationYear "2021" @default.
- W3199281570 type Work @default.
- W3199281570 sameAs 3199281570 @default.
- W3199281570 citedByCount "0" @default.
- W3199281570 crossrefType "journal-article" @default.
- W3199281570 hasAuthorship W3199281570A5013126161 @default.
- W3199281570 hasAuthorship W3199281570A5032153642 @default.
- W3199281570 hasAuthorship W3199281570A5041637547 @default.
- W3199281570 hasAuthorship W3199281570A5045685247 @default.
- W3199281570 hasAuthorship W3199281570A5091912184 @default.
- W3199281570 hasConcept C138885662 @default.
- W3199281570 hasConceptScore W3199281570C138885662 @default.
- W3199281570 hasIssue "9" @default.
- W3199281570 hasLocation W31992815701 @default.
- W3199281570 hasOpenAccess W3199281570 @default.
- W3199281570 hasPrimaryLocation W31992815701 @default.
- W3199281570 hasRelatedWork W11415525 @default.
- W3199281570 hasRelatedWork W15987661 @default.
- W3199281570 hasRelatedWork W17046487 @default.
- W3199281570 hasRelatedWork W19227772 @default.
- W3199281570 hasRelatedWork W22246581 @default.
- W3199281570 hasRelatedWork W2429397 @default.
- W3199281570 hasRelatedWork W24437571 @default.
- W3199281570 hasRelatedWork W277811 @default.
- W3199281570 hasRelatedWork W7136161 @default.
- W3199281570 hasRelatedWork W8096458 @default.
- W3199281570 hasVolume "107" @default.
- W3199281570 isParatext "false" @default.
- W3199281570 isRetracted "false" @default.
- W3199281570 magId "3199281570" @default.
- W3199281570 workType "article" @default.