FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199282695> ?p ?o ?g. }

• W3199282695 abstract "It is estimated that up to 80% of infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are asymptomatic and asymptomatic patients can still effectively transmit the virus and cause disease. While much of the effort has been placed on decoding single nucleotide variation in SARS-CoV-2 genomes, considerably less is known about their transcript variation and any correlation with clinical severity in human hosts, as defined here by the presence or absence of symptoms.To assess viral genomic signatures of disease severity, we conducted a systematic characterization of SARS-CoV-2 transcripts and genetic variants in 81 clinical specimens collected from symptomatic and asymptomatic individuals using multi-scale transcriptomic analyses including amplicon-seq, short-read metatranscriptome and long-read Iso-seq.Here we show a highly coordinated and consistent pattern of sgRNA expression from individuals with robust SARS-CoV-2 symptomatic infection and their expression is significantly repressed in the asymptomatic infections. We also observe widespread inter- and intra-patient variants in viral RNAs, known as quasispecies frequently found in many RNA viruses. We identify unique sets of deletions preferentially found primarily in symptomatic individuals, with many likely to confer changes in SARS-CoV-2 virulence and host responses. Moreover, these frequently occurring structural variants in SARS-CoV-2 genomes serve as a mechanism to further induce SARS-CoV-2 proteome complexity.Our results indicate that differential sgRNA expression and structural mutational burden are highly correlated with the clinical severity of SARS-CoV-2 infection. Longitudinally monitoring sgRNA expression and structural diversity could further guide treatment responses, testing strategies, and vaccine development." @default.
• W3199282695 created "2021-09-27" @default.
• W3199282695 creator A5005961131 @default.
• W3199282695 creator A5008229779 @default.
• W3199282695 creator A5014913705 @default.
• W3199282695 creator A5017332416 @default.
• W3199282695 creator A5025894522 @default.
• W3199282695 creator A5029371578 @default.
• W3199282695 creator A5036614822 @default.
• W3199282695 creator A5047750908 @default.
• W3199282695 creator A5049775141 @default.
• W3199282695 creator A5058591171 @default.
• W3199282695 creator A5061824149 @default.
• W3199282695 creator A5065585995 @default.
• W3199282695 creator A5065951622 @default.
• W3199282695 creator A5075889094 @default.
• W3199282695 date "2021-09-22" @default.
• W3199282695 modified "2023-10-08" @default.
• W3199282695 title "Reduced subgenomic RNA expression is a molecular indicator of asymptomatic SARS-CoV-2 infection" @default.
• W3199282695 cites W1544561280 @default.
• W3199282695 cites W1862727846 @default.
• W3199282695 cites W1930242224 @default.
• W3199282695 cites W1989561750 @default.
• W3199282695 cites W1996824979 @default.
• W3199282695 cites W2003574450 @default.
• W3199282695 cites W2026892545 @default.
• W3199282695 cites W2027191557 @default.
• W3199282695 cites W2036897871 @default.
• W3199282695 cites W2038395919 @default.
• W3199282695 cites W2050843600 @default.
• W3199282695 cites W2060261240 @default.
• W3199282695 cites W2066524276 @default.
• W3199282695 cites W2069047111 @default.
• W3199282695 cites W2073918065 @default.
• W3199282695 cites W2081465448 @default.
• W3199282695 cites W2086431635 @default.
• W3199282695 cites W2091377998 @default.
• W3199282695 cites W2094875270 @default.
• W3199282695 cites W2099450221 @default.
• W3199282695 cites W2102109092 @default.
• W3199282695 cites W2110201489 @default.
• W3199282695 cites W2112078820 @default.
• W3199282695 cites W2120479348 @default.
• W3199282695 cites W2125529677 @default.
• W3199282695 cites W2144073791 @default.
• W3199282695 cites W2160567170 @default.
• W3199282695 cites W2169456326 @default.
• W3199282695 cites W2258422636 @default.
• W3199282695 cites W2301015295 @default.
• W3199282695 cites W2463761386 @default.
• W3199282695 cites W2587970647 @default.
• W3199282695 cites W2902073423 @default.
• W3199282695 cites W2903899730 @default.
• W3199282695 cites W2951160681 @default.
• W3199282695 cites W2952045272 @default.
• W3199282695 cites W2952109315 @default.
• W3199282695 cites W2969431118 @default.
• W3199282695 cites W2991012415 @default.
• W3199282695 cites W3007886991 @default.
• W3199282695 cites W3008394341 @default.
• W3199282695 cites W3009607814 @default.
• W3199282695 cites W3013525829 @default.
• W3199282695 cites W3013893137 @default.
• W3199282695 cites W3016591679 @default.
• W3199282695 cites W3017680297 @default.
• W3199282695 cites W3019291397 @default.
• W3199282695 cites W3023558422 @default.
• W3199282695 cites W3029338293 @default.
• W3199282695 cites W3030932953 @default.
• W3199282695 cites W3031512972 @default.
• W3199282695 cites W3033718954 @default.
• W3199282695 cites W3036178624 @default.
• W3199282695 cites W3038505425 @default.
• W3199282695 cites W3038958209 @default.
• W3199282695 cites W3039901154 @default.
• W3199282695 cites W3043391491 @default.
• W3199282695 cites W3044443183 @default.
• W3199282695 cites W3045327938 @default.
• W3199282695 cites W3047232801 @default.
• W3199282695 cites W3047645360 @default.
• W3199282695 cites W3048671222 @default.
• W3199282695 cites W3049233984 @default.
• W3199282695 cites W3079001956 @default.
• W3199282695 cites W3083653247 @default.
• W3199282695 cites W3087248341 @default.
• W3199282695 cites W3087629475 @default.
• W3199282695 cites W3094472617 @default.
• W3199282695 cites W3095392823 @default.
• W3199282695 cites W3101238500 @default.
• W3199282695 cites W3103465643 @default.
• W3199282695 cites W3106919367 @default.
• W3199282695 cites W3107258715 @default.
• W3199282695 cites W3107972756 @default.
• W3199282695 cites W3118873013 @default.
• W3199282695 cites W3122148095 @default.
• W3199282695 cites W3145779445 @default.
• W3199282695 cites W3193970141 @default.
• W3199282695 cites W96734778 @default.
• W3199282695 cites W974578078 @default.
• W3199282695 doi "https://doi.org/10.1038/s43856-021-00034-y" @default.

• next