FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199290437> ?p ?o ?g. }

• W3199290437 endingPage "1059" @default.
• W3199290437 startingPage "1048" @default.
• W3199290437 abstract "Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine. Bupivacaine can inhibit protein kinase B (AKT) phosphorylation and activated adenosine monophosphate-activated protein kinase alpha (AMPKα). It can decouple mitochondrial oxidative phosphorylation and enhance reactive oxygen species (ROS) production. Apelin enhances the phosphatidylinositol 3-kinase (PI3K)/AKT and AMPK/acetyl-CoA carboxylase (ACC) pathways, promotes the complete fatty acid oxidation in the heart, and reduces the release of ROS. In this study, we examined whether exogenous (Pyr1) apelin-13 could reverse bupivacaine-induced cardiotoxicity.We used the bupivacaine-induced inhibition model in adult male Sprague Dawley (SD) rats (n = 48) and H9c2 cardiomyocyte cell cultures to explore the role of apelin-13 in the reversal of bupivacaine cardiotoxicity, and its possible mechanism of action. AMPKα, ACC, carnitine palmitoyl transferase (CPT), PI3K, AKT, superoxide dismutase 1 (SOD1), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (p47-phox) were quantified. Changes in mitochondrial ultrastructure were examined, and mitochondrial DNA, cell viability, ROS release, oxygen consumption rate (OCR) were determined.Apelin-13 reduced bupivacaine-induced mitochondrial DNA lesions in SD rats (P < .001), while increasing the expression of AMPKα (P = .007) and PI3K (P = .002). Furthermore, apelin-13 blocked bupivacaine-induced depolarization of the mitochondrial membrane potential (P = .019) and the bupivacaine-induced increases in ROS (P = .001). Also, the AMPK pathway was activated by bupivacaine as well as apelin-13 (P = .002) in H9c2 cardiomyocytes. Additionally, the reduction in the PI3K expression by bupivacaine was mitigated by apelin-13 in H9c2 cardiomyocytes (P = .001). While the aforementioned changes induced by bupivacaine were not abated by apelin-13 after pretreatment with AMPK inhibitor compound C; the bupivacaine-induced changes were still mitigated by apelin-13, even when pretreated with PI3K inhibitor-LY294002.Apelin-13 treatment reduced bupivacaine-induced oxidative stress, attenuated mitochondrial morphological changes and mitochondrial DNA damage, enhanced mitochondrial energy metabolism, and ultimately reversed bupivacaine-induced cardiotoxicity. Our results suggest a role for the AMPK in apelin-13 reversal of bupivacaine-induced cardiotoxicity." @default.
• W3199290437 created "2021-09-27" @default.
• W3199290437 creator A5003994767 @default.
• W3199290437 creator A5012766239 @default.
• W3199290437 creator A5016698028 @default.
• W3199290437 creator A5032719475 @default.
• W3199290437 creator A5034662506 @default.
• W3199290437 creator A5043161993 @default.
• W3199290437 creator A5055164257 @default.
• W3199290437 creator A5056690469 @default.
• W3199290437 creator A5058743869 @default.
• W3199290437 creator A5065738624 @default.
• W3199290437 creator A5070275317 @default.
• W3199290437 creator A5077906810 @default.
• W3199290437 date "2021-08-17" @default.
• W3199290437 modified "2023-10-12" @default.
• W3199290437 title "Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate–Activated Protein Kinase Pathway" @default.
• W3199290437 cites W1853192652 @default.
• W3199290437 cites W1992185401 @default.
• W3199290437 cites W2034955218 @default.
• W3199290437 cites W2047822066 @default.
• W3199290437 cites W2055988446 @default.
• W3199290437 cites W2060838250 @default.
• W3199290437 cites W2062565749 @default.
• W3199290437 cites W2063878060 @default.
• W3199290437 cites W2086411642 @default.
• W3199290437 cites W2094657005 @default.
• W3199290437 cites W2116563158 @default.
• W3199290437 cites W2128715562 @default.
• W3199290437 cites W2143474482 @default.
• W3199290437 cites W2151948477 @default.
• W3199290437 cites W2155528804 @default.
• W3199290437 cites W2168039666 @default.
• W3199290437 cites W2191568640 @default.
• W3199290437 cites W220127227 @default.
• W3199290437 cites W2286554493 @default.
• W3199290437 cites W2335600490 @default.
• W3199290437 cites W2472395736 @default.
• W3199290437 cites W2564360633 @default.
• W3199290437 cites W2587627370 @default.
• W3199290437 cites W2728069603 @default.
• W3199290437 cites W2736198251 @default.
• W3199290437 cites W2765134326 @default.
• W3199290437 cites W2768804672 @default.
• W3199290437 cites W2802924594 @default.
• W3199290437 cites W2908372949 @default.
• W3199290437 cites W3012951464 @default.
• W3199290437 cites W3042566401 @default.
• W3199290437 cites W4234588731 @default.
• W3199290437 doi "https://doi.org/10.1213/ane.0000000000005692" @default.
• W3199290437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34524989" @default.
• W3199290437 hasPublicationYear "2021" @default.
• W3199290437 type Work @default.
• W3199290437 sameAs 3199290437 @default.
• W3199290437 citedByCount "6" @default.
• W3199290437 countsByYear W31992904372023 @default.
• W3199290437 crossrefType "journal-article" @default.
• W3199290437 hasAuthorship W3199290437A5003994767 @default.
• W3199290437 hasAuthorship W3199290437A5012766239 @default.
• W3199290437 hasAuthorship W3199290437A5016698028 @default.
• W3199290437 hasAuthorship W3199290437A5032719475 @default.
• W3199290437 hasAuthorship W3199290437A5034662506 @default.
• W3199290437 hasAuthorship W3199290437A5043161993 @default.
• W3199290437 hasAuthorship W3199290437A5055164257 @default.
• W3199290437 hasAuthorship W3199290437A5056690469 @default.
• W3199290437 hasAuthorship W3199290437A5058743869 @default.
• W3199290437 hasAuthorship W3199290437A5065738624 @default.
• W3199290437 hasAuthorship W3199290437A5070275317 @default.
• W3199290437 hasAuthorship W3199290437A5077906810 @default.
• W3199290437 hasConcept C11960822 @default.
• W3199290437 hasConcept C126322002 @default.
• W3199290437 hasConcept C134018914 @default.
• W3199290437 hasConcept C170493617 @default.
• W3199290437 hasConcept C2776780712 @default.
• W3199290437 hasConcept C2779546753 @default.
• W3199290437 hasConcept C2780124434 @default.
• W3199290437 hasConcept C2781328992 @default.
• W3199290437 hasConcept C48349386 @default.
• W3199290437 hasConcept C55493867 @default.
• W3199290437 hasConcept C62478195 @default.
• W3199290437 hasConcept C71924100 @default.
• W3199290437 hasConcept C75217442 @default.
• W3199290437 hasConcept C86554907 @default.
• W3199290437 hasConcept C86803240 @default.
• W3199290437 hasConcept C97029542 @default.
• W3199290437 hasConcept C98274493 @default.
• W3199290437 hasConceptScore W3199290437C11960822 @default.
• W3199290437 hasConceptScore W3199290437C126322002 @default.
• W3199290437 hasConceptScore W3199290437C134018914 @default.
• W3199290437 hasConceptScore W3199290437C170493617 @default.
• W3199290437 hasConceptScore W3199290437C2776780712 @default.
• W3199290437 hasConceptScore W3199290437C2779546753 @default.
• W3199290437 hasConceptScore W3199290437C2780124434 @default.
• W3199290437 hasConceptScore W3199290437C2781328992 @default.
• W3199290437 hasConceptScore W3199290437C48349386 @default.
• W3199290437 hasConceptScore W3199290437C55493867 @default.
• W3199290437 hasConceptScore W3199290437C62478195 @default.
• W3199290437 hasConceptScore W3199290437C71924100 @default.

• next