Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199301322> ?p ?o ?g. }
- W3199301322 endingPage "114630" @default.
- W3199301322 startingPage "114630" @default.
- W3199301322 abstract "Salvia limbata C. A. Mey. (Persian name: Maryam Goli-e-labeh dar) has been used for treating central nervous disorders such as insomnia, anxiety and depression in Persian traditional medicine. S. limbata is known for its pharmacological activities which could be at least in a part, upon the presence of rosmarinic acid (RA). However, the sedative-hypnotic effect, anxiolytic activity, possible side effects, and the mechanism of action of S. limbata extract has not yet been examined.In the current study the sedative-hypnotic effect, anxiolytic activity, possible side effects, and the mechanism of action of S. limbata extracts were evaluated. Besides, the effects of altitude and phenological stage on the RA content of S. limbata were investigated.Sedative-hypnotic and anxiolytic effects were evaluated through the pentobarbital induced loss of righting reflex test and open field test, respectively. Flumazenil was used to reveal the mechanism of action. Possible side effects were investigated in the passive avoidance and grip strength tests. Besides, the effects of altitude and phenological stage (vegetative, flowering, and seed setting) on the RA content of S. limbata were evaluated using reversed-phase high-performance liquid chromatography (RP-HPLC).Following behavioral tests, sedative-hypnotic and anxiolytic effects were observed. Since the observed effects were reversed by flumazenil and no side effect on the memory and muscle strength was reported, modulation of the α1-containing GABA-A receptors could be proposed as one of the involved mechanisms. According to the RP-HPLC analysis, harvesting S. limbata in the vegetative stage at the altitude of 2500 m led to the highest content of RA (8.67 ± 0.13 mg/g dry matter). Among different extract of the plant samples collected in the vegetative stage at the altitude of 2500 m, the hydroalcoholic extract showed the highest rosmarinic acid content.The obtained results help to find the optimum situation to gain the highest content of RA as well as the pharmacological activity that could be economically important for the pharmaceutical industries." @default.
- W3199301322 created "2021-09-27" @default.
- W3199301322 creator A5020592239 @default.
- W3199301322 creator A5043921809 @default.
- W3199301322 creator A5072535371 @default.
- W3199301322 creator A5074057252 @default.
- W3199301322 creator A5089994806 @default.
- W3199301322 date "2022-01-01" @default.
- W3199301322 modified "2023-09-23" @default.
- W3199301322 title "Sedative-hypnotic, anxiolytic and possible side effects of Salvia limbata C. A. Mey. Extracts and the effects of phenological stage and altitude on the rosmarinic acid content" @default.
- W3199301322 cites W1970622888 @default.
- W3199301322 cites W1978567840 @default.
- W3199301322 cites W1998712066 @default.
- W3199301322 cites W2005984856 @default.
- W3199301322 cites W2013733078 @default.
- W3199301322 cites W2015707904 @default.
- W3199301322 cites W2025633126 @default.
- W3199301322 cites W2037968418 @default.
- W3199301322 cites W2047086418 @default.
- W3199301322 cites W2061540742 @default.
- W3199301322 cites W2075670793 @default.
- W3199301322 cites W2076785795 @default.
- W3199301322 cites W2101478488 @default.
- W3199301322 cites W2120882419 @default.
- W3199301322 cites W2128978319 @default.
- W3199301322 cites W2133869788 @default.
- W3199301322 cites W2136102623 @default.
- W3199301322 cites W2159548807 @default.
- W3199301322 cites W2166080419 @default.
- W3199301322 cites W2488944272 @default.
- W3199301322 cites W2497564111 @default.
- W3199301322 cites W2501798356 @default.
- W3199301322 cites W2553086500 @default.
- W3199301322 cites W2586760161 @default.
- W3199301322 cites W2753458553 @default.
- W3199301322 cites W2777924872 @default.
- W3199301322 cites W2778474459 @default.
- W3199301322 cites W2809458726 @default.
- W3199301322 cites W2897296179 @default.
- W3199301322 cites W2948612556 @default.
- W3199301322 cites W2978003416 @default.
- W3199301322 cites W2998552303 @default.
- W3199301322 cites W3007151130 @default.
- W3199301322 cites W3034124566 @default.
- W3199301322 cites W3076625387 @default.
- W3199301322 cites W3081523753 @default.
- W3199301322 cites W3081881108 @default.
- W3199301322 cites W3082922899 @default.
- W3199301322 cites W3104609624 @default.
- W3199301322 cites W3123429085 @default.
- W3199301322 cites W3130207430 @default.
- W3199301322 doi "https://doi.org/10.1016/j.jep.2021.114630" @default.
- W3199301322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34517061" @default.
- W3199301322 hasPublicationYear "2022" @default.
- W3199301322 type Work @default.
- W3199301322 sameAs 3199301322 @default.
- W3199301322 citedByCount "3" @default.
- W3199301322 countsByYear W31993013222022 @default.
- W3199301322 crossrefType "journal-article" @default.
- W3199301322 hasAuthorship W3199301322A5020592239 @default.
- W3199301322 hasAuthorship W3199301322A5043921809 @default.
- W3199301322 hasAuthorship W3199301322A5072535371 @default.
- W3199301322 hasAuthorship W3199301322A5074057252 @default.
- W3199301322 hasAuthorship W3199301322A5089994806 @default.
- W3199301322 hasConcept C168258287 @default.
- W3199301322 hasConcept C170493617 @default.
- W3199301322 hasConcept C2777602617 @default.
- W3199301322 hasConcept C2777765862 @default.
- W3199301322 hasConcept C2778004101 @default.
- W3199301322 hasConcept C2778409475 @default.
- W3199301322 hasConcept C2778771215 @default.
- W3199301322 hasConcept C2910067630 @default.
- W3199301322 hasConcept C55493867 @default.
- W3199301322 hasConcept C556039675 @default.
- W3199301322 hasConcept C71924100 @default.
- W3199301322 hasConcept C86803240 @default.
- W3199301322 hasConcept C98274493 @default.
- W3199301322 hasConceptScore W3199301322C168258287 @default.
- W3199301322 hasConceptScore W3199301322C170493617 @default.
- W3199301322 hasConceptScore W3199301322C2777602617 @default.
- W3199301322 hasConceptScore W3199301322C2777765862 @default.
- W3199301322 hasConceptScore W3199301322C2778004101 @default.
- W3199301322 hasConceptScore W3199301322C2778409475 @default.
- W3199301322 hasConceptScore W3199301322C2778771215 @default.
- W3199301322 hasConceptScore W3199301322C2910067630 @default.
- W3199301322 hasConceptScore W3199301322C55493867 @default.
- W3199301322 hasConceptScore W3199301322C556039675 @default.
- W3199301322 hasConceptScore W3199301322C71924100 @default.
- W3199301322 hasConceptScore W3199301322C86803240 @default.
- W3199301322 hasConceptScore W3199301322C98274493 @default.
- W3199301322 hasLocation W31993013221 @default.
- W3199301322 hasLocation W31993013222 @default.
- W3199301322 hasOpenAccess W3199301322 @default.
- W3199301322 hasPrimaryLocation W31993013221 @default.
- W3199301322 hasRelatedWork W1975791749 @default.
- W3199301322 hasRelatedWork W2024244810 @default.
- W3199301322 hasRelatedWork W2083814207 @default.
- W3199301322 hasRelatedWork W2279985139 @default.