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- W3199319072 abstract "Presenter: Marc Najjar MD | Columbia University Background: Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. Surgical treatment is the only potential curative option, while systemic therapy often has limited success. We sought in this study to describe the outcomes of patients treated with locoregional therapy (LRT) for unresectable or recurrent iCCA. Methods: This is a single-center retrospective cohort study of all consecutive patients who underwent LRT (including Transarterial chemoembolization (TACE) and Yttrium-90 radioembolization (Y-90)) for unresectable or recurrent iCCA between 2000 and 2018. Patients demographics, tumor characteristics and tumor-directed interventions were collected and overall survival (OS) assessed. Results: A total of 45 patients were identified, median age was 61 years (IQR 51 – 71) and 58% were female. Thirty-three percent of patients had iCCA stage 4 (AJCC 8th edition), 49% received Y-90 while 58% got TACE, a median of 1.5 LRT interventions (IQR 1 – 2) were used for each patient. The median OS was 12 months (IQR 4 – 22), it was higher in patients treated for iCCA recurrence following liver resection as compared to those treated exclusively with LRT (15 vs 9 months, p=0.055) [Figures]. Conclusion: In unresectable and recurrent iCCA following LR, loco-regional therapies can offer a survival advantage over systemic therapy alone." @default.
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- W3199319072 date "2021-01-01" @default.
- W3199319072 modified "2023-09-26" @default.
- W3199319072 title "Locoregional therapy for unresectable and recurrent intrahepatic cholangiocarcinoma" @default.
- W3199319072 doi "https://doi.org/10.1016/j.hpb.2021.06.290" @default.
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