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• W3199325105 abstract "Skin and soft tissue infections require effective and sustained topical administration. Platensimycin (PTM) is a natural drug lead that targets bacterial fatty acid synthases and has a great potential to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). To facilitate the use of PTM against local MRSA infections, we prepared polyacrylamide hydrogels containing polyamidoamine (PAMAM)/PTM nanoparticles (NP-gel(PTM)) for the controlled release of PTM. NP-gel(PTM) can continuously inhibit the growth of MRSA and its biofilm formation in simulated drug flow models in vitro. In situ implantation of NP-gel(PTM) could treat MRSA-infected subcutaneous soft tissues without toxicity. For MRSA-infected skin wounds, NP-gel(PTM) not only showed strong anti-MRSA activity but also accelerated more wound healing than the widely used antibiotic mupirocin. Collectively, PTM is expected to be used in this safe and effective NP-gel delivery platform for the treatment of local infections, which might help to alleviate the current antibiotic resistance crisis." @default.
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• W3199325105 date "2021-09-23" @default.
• W3199325105 modified "2023-10-14" @default.
• W3199325105 title "Nanoparticle-Hydrogel Systems Containing Platensimycin for Local Treatment of Methicillin-Resistant <i>Staphylococcus aureus</i> Infection" @default.
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• W3199325105 doi "https://doi.org/10.1021/acs.molpharmaceut.1c00523" @default.
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