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- W3199328305 abstract "Epstein-Barr virus (EBV) is known to be involved in gastric carcinogenesis. EBV-associated early gastric carcinoma (EBVEGC) has a lower incidence of lymph node involvement and could be an expanded indication for endoscopic submucosal dissection (ESD) treatment.To clarify the prevalence and clinicopathological features of EBVEGC.This study reviewed 618 lesions in 519 patients treated with ESD between 2014 and 2016. Tissue microarray sections were subjected to in situ hybridization staining for EBV-encoded small RNA transcripts (EBER). Lesions positive for EBER were compared with control lesions and were retrospectively analyzed.12 (1.9%) of the 618 lesions were EBVEGC. EBVEGCs were more frequently located near the atrophic border than control lesions in the middle or upper stomach and were reddish. EBVEGC invasion was deeper and more often histologically undifferentiated. On narrow-band imaging magnifying endoscopy, the EBVEGC group significantly more often showed an endoscopic lace pattern, defined as an absent or obscure microsurface pattern and a microvascular pattern of a tiny, dense, and irregular subepithelial capillary network. The rate of curative resection was significantly lower in the EBVEGC group.Only 1.9% of the ESD specimens were EBV-positive. Endoscopic features could raise clinical suspicion of EBV infection." @default.
- W3199328305 created "2021-09-27" @default.
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- W3199328305 date "2022-07-01" @default.
- W3199328305 modified "2023-09-24" @default.
- W3199328305 title "Clinicopathological features of Epstein-Barr virus–associated superficial early stage gastric cancer treated with endoscopic submucosal dissection" @default.
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- W3199328305 doi "https://doi.org/10.1016/j.dld.2021.08.023" @default.
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