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- W3199336672 abstract "microRNAs (miRNAs or miRs) are short non-coding RNA molecules which have been shown to be dysregulated and released into the extracellular milieu as a result of many drug and non-drug-induced pathologies in different organ systems. Consequently, circulating miRs have been proposed as useful biomarkers of many disease states, including drug-induced tissue injury. miRs have shown potential to support or even replace the existing traditional biomarkers of drug-induced toxicity in terms of sensitivity and specificity, and there is some evidence for their improved diagnostic and prognostic value. However, several pre-analytical and analytical challenges, mainly associated with assay standardization, require solutions before circulating miRs can be successfully translated into the clinic. This review will consider the value and potential for the use of circulating miRs in drug-safety assessment and describe a systems approach to the analysis of the miRNAome in the discovery setting, as well as highlighting standardization issues that at this stage prevent their clinical use as biomarkers. Highlighting these challenges will hopefully drive future research into finding appropriate solutions, and eventually circulating miRs may be translated to the clinic where their undoubted biomarker potential can be used to benefit patients in rapid, easy to use, point-of-care test systems." @default.
- W3199336672 created "2021-09-27" @default.
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- W3199336672 date "2021-09-12" @default.
- W3199336672 modified "2023-10-09" @default.
- W3199336672 title "Systems analysis of miRNA biomarkers to inform drug safety" @default.
- W3199336672 cites W1196671365 @default.
- W3199336672 cites W1584882869 @default.
- W3199336672 cites W1810606235 @default.
- W3199336672 cites W1964631388 @default.
- W3199336672 cites W1969879564 @default.
- W3199336672 cites W1970654589 @default.
- W3199336672 cites W1972471022 @default.
- W3199336672 cites W1974540586 @default.
- W3199336672 cites W1976341065 @default.
- W3199336672 cites W1977066847 @default.
- W3199336672 cites W1982810690 @default.
- W3199336672 cites W1983327828 @default.
- W3199336672 cites W1983932066 @default.
- W3199336672 cites W1986581709 @default.
- W3199336672 cites W1987665704 @default.
- W3199336672 cites W1988680583 @default.
- W3199336672 cites W1990602103 @default.
- W3199336672 cites W1992746042 @default.
- W3199336672 cites W1997218466 @default.
- W3199336672 cites W1999869217 @default.
- W3199336672 cites W2000966089 @default.
- W3199336672 cites W2017611405 @default.
- W3199336672 cites W2017857120 @default.
- W3199336672 cites W2019826921 @default.
- W3199336672 cites W2020508492 @default.
- W3199336672 cites W2021248069 @default.
- W3199336672 cites W2022057640 @default.
- W3199336672 cites W2024206172 @default.
- W3199336672 cites W2026216861 @default.
- W3199336672 cites W2032696674 @default.
- W3199336672 cites W2035437970 @default.
- W3199336672 cites W2039107480 @default.
- W3199336672 cites W2045962872 @default.
- W3199336672 cites W2046298776 @default.
- W3199336672 cites W2048763532 @default.
- W3199336672 cites W2050337173 @default.
- W3199336672 cites W2054984901 @default.
- W3199336672 cites W2055313665 @default.
- W3199336672 cites W2061536430 @default.
- W3199336672 cites W2066210214 @default.
- W3199336672 cites W2067120227 @default.
- W3199336672 cites W2074689365 @default.
- W3199336672 cites W2076984671 @default.
- W3199336672 cites W2079747084 @default.
- W3199336672 cites W2088358480 @default.
- W3199336672 cites W2089055162 @default.
- W3199336672 cites W2092332477 @default.
- W3199336672 cites W2092840595 @default.
- W3199336672 cites W2094977970 @default.
- W3199336672 cites W2096551466 @default.
- W3199336672 cites W2097233439 @default.
- W3199336672 cites W2098214061 @default.
- W3199336672 cites W2101792171 @default.
- W3199336672 cites W2104607843 @default.
- W3199336672 cites W2104780575 @default.
- W3199336672 cites W2105679485 @default.
- W3199336672 cites W2106191801 @default.
- W3199336672 cites W2108107515 @default.
- W3199336672 cites W2111663113 @default.
- W3199336672 cites W2111848990 @default.
- W3199336672 cites W2112150773 @default.
- W3199336672 cites W2113076162 @default.
- W3199336672 cites W2115093090 @default.
- W3199336672 cites W2115557844 @default.
- W3199336672 cites W2116646339 @default.
- W3199336672 cites W2119604948 @default.
- W3199336672 cites W2124358392 @default.
- W3199336672 cites W2127007225 @default.
- W3199336672 cites W2128493256 @default.
- W3199336672 cites W2129711491 @default.
- W3199336672 cites W2130596514 @default.
- W3199336672 cites W2131910853 @default.