FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199342805> ?p ?o ?g. }

• W3199342805 abstract "Ischemia and reperfusion injury is an early inflammatory process during liver transplantation that impacts on graft function and clinical outcomes. Interleukin (IL)-33 is a danger-associated molecular pattern involved in kidney ischemia/reperfusion injury and several liver diseases. The aims were to assess whether IL-33 was released as an alarmin responsible for ischemia/reperfusion injury in a mouse model of warm hepatic ischemia, and whether this hypothesis could also apply in the setting of human liver transplantation. First, a model of warm hepatic ischemia/reperfusion was used in wild-type and IL-33–deficient mice. Severity of ischemia/reperfusion injury was assessed with ALT and histological analysis. Then, serum IL-33 was measured in a pilot cohort of 40 liver transplant patients. Hemodynamic postreperfusion syndrome, graft dysfunction (assessed by model for early allograft scoring &gt;6), renal failure, and tissue lesions on time-zero biopsies were assessed. In the mouse model, IL-33 was constitutively expressed in the nucleus of endothelial cells, immediately released in response to hepatic pedicle clamping without neosynthesis, and participated in the recruitment of neutrophils and tissue injury on site. The kinetics of IL-33 in liver transplant patients strikingly matched the ones in the animal model, as attested by serum levels reaching a peak immediately after reperfusion, which correlated to clinical outcomes including postreperfusion syndrome, posttransplant renal failure, graft dysfunction, and histological lesions of ischemia/reperfusion injury. IL-33 was an independent factor of graft dysfunction with a cutoff of IL-33 at 73 pg/ml after reperfusion (73% sensitivity, area under the curve of 0.76). Taken together, these findings establish the immediate implication of IL-33 acting as an alarmin in liver I/R injury and provide evidence of its close association with cardinal features of early liver injury-associated disorders in LT patients." @default.
• W3199342805 created "2021-09-27" @default.
• W3199342805 creator A5008547610 @default.
• W3199342805 creator A5026809269 @default.
• W3199342805 creator A5041054996 @default.
• W3199342805 creator A5045897447 @default.
• W3199342805 creator A5049544266 @default.
• W3199342805 creator A5063129331 @default.
• W3199342805 creator A5070506901 @default.
• W3199342805 creator A5083198355 @default.
• W3199342805 creator A5083211032 @default.
• W3199342805 creator A5089589171 @default.
• W3199342805 creator A5090112028 @default.
• W3199342805 creator A5091857245 @default.
• W3199342805 date "2021-09-21" @default.
• W3199342805 modified "2023-10-14" @default.
• W3199342805 title "Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation" @default.
• W3199342805 cites W1548421436 @default.
• W3199342805 cites W162447880 @default.
• W3199342805 cites W1968955229 @default.
• W3199342805 cites W1969480313 @default.
• W3199342805 cites W1972541045 @default.
• W3199342805 cites W2000675453 @default.
• W3199342805 cites W2002226263 @default.
• W3199342805 cites W2010180179 @default.
• W3199342805 cites W2011958522 @default.
• W3199342805 cites W2015053270 @default.
• W3199342805 cites W2017332381 @default.
• W3199342805 cites W2026274122 @default.
• W3199342805 cites W2031915073 @default.
• W3199342805 cites W2044109925 @default.
• W3199342805 cites W2051576182 @default.
• W3199342805 cites W2053115044 @default.
• W3199342805 cites W2065788180 @default.
• W3199342805 cites W2079282946 @default.
• W3199342805 cites W2081885723 @default.
• W3199342805 cites W2138044472 @default.
• W3199342805 cites W2145409418 @default.
• W3199342805 cites W2148198599 @default.
• W3199342805 cites W2510497553 @default.
• W3199342805 cites W2512728920 @default.
• W3199342805 cites W2552459283 @default.
• W3199342805 cites W2727926297 @default.
• W3199342805 cites W2758829149 @default.
• W3199342805 cites W2779261498 @default.
• W3199342805 cites W2781665857 @default.
• W3199342805 cites W2785644619 @default.
• W3199342805 cites W2884285824 @default.
• W3199342805 cites W2898545691 @default.
• W3199342805 cites W2969017711 @default.
• W3199342805 cites W2973962175 @default.
• W3199342805 cites W3000220599 @default.
• W3199342805 cites W3021018447 @default.
• W3199342805 cites W3026994380 @default.
• W3199342805 cites W3030029238 @default.
• W3199342805 cites W3044387152 @default.
• W3199342805 cites W3081286785 @default.
• W3199342805 cites W3091794858 @default.
• W3199342805 cites W4296816736 @default.
• W3199342805 doi "https://doi.org/10.3389/fimmu.2021.744927" @default.
• W3199342805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8491545" @default.
• W3199342805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34621275" @default.
• W3199342805 hasPublicationYear "2021" @default.
• W3199342805 type Work @default.
• W3199342805 sameAs 3199342805 @default.
• W3199342805 citedByCount "9" @default.
• W3199342805 countsByYear W31993428052021 @default.
• W3199342805 countsByYear W31993428052022 @default.
• W3199342805 countsByYear W31993428052023 @default.
• W3199342805 crossrefType "journal-article" @default.
• W3199342805 hasAuthorship W3199342805A5008547610 @default.
• W3199342805 hasAuthorship W3199342805A5026809269 @default.
• W3199342805 hasAuthorship W3199342805A5041054996 @default.
• W3199342805 hasAuthorship W3199342805A5045897447 @default.
• W3199342805 hasAuthorship W3199342805A5049544266 @default.
• W3199342805 hasAuthorship W3199342805A5063129331 @default.
• W3199342805 hasAuthorship W3199342805A5070506901 @default.
• W3199342805 hasAuthorship W3199342805A5083198355 @default.
• W3199342805 hasAuthorship W3199342805A5083211032 @default.
• W3199342805 hasAuthorship W3199342805A5089589171 @default.
• W3199342805 hasAuthorship W3199342805A5090112028 @default.
• W3199342805 hasAuthorship W3199342805A5091857245 @default.
• W3199342805 hasBestOaLocation W31993428051 @default.
• W3199342805 hasConcept C126322002 @default.
• W3199342805 hasConcept C142724271 @default.
• W3199342805 hasConcept C2779609443 @default.
• W3199342805 hasConcept C2780114680 @default.
• W3199342805 hasConcept C2911091166 @default.
• W3199342805 hasConcept C541997718 @default.
• W3199342805 hasConcept C71924100 @default.
• W3199342805 hasConcept C90924648 @default.
• W3199342805 hasConceptScore W3199342805C126322002 @default.
• W3199342805 hasConceptScore W3199342805C142724271 @default.
• W3199342805 hasConceptScore W3199342805C2779609443 @default.
• W3199342805 hasConceptScore W3199342805C2780114680 @default.
• W3199342805 hasConceptScore W3199342805C2911091166 @default.
• W3199342805 hasConceptScore W3199342805C541997718 @default.
• W3199342805 hasConceptScore W3199342805C71924100 @default.
• W3199342805 hasConceptScore W3199342805C90924648 @default.
• W3199342805 hasLocation W31993428051 @default.

• next