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• W3199355525 abstract "Abstract Lithium is a nutritional trace element, used clinically as an anti‐depressant. Preclinically, lithium has neuroprotective effects in invertebrates and mice, and it can also extend lifespan in fission yeast, C. elegans and Drosophila . An inverse correlation of human mortality with the concentration of lithium in tap water suggests a possible, evolutionarily conserved mechanism mediating longevity. Here, we assessed the effects of lithium treatment on lifespan and ageing parameters in mice. Lithium has a narrow therapeutic dose range, and overdosing can severely affect organ health. Within the tolerable dosing range, we saw some mildly positive effects of lithium on health span but not on lifespan." @default.
• W3199355525 created "2021-09-27" @default.
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• W3199355525 date "2021-09-17" @default.
• W3199355525 modified "2023-10-17" @default.
• W3199355525 title "Lithium can mildly increase health during ageing but not lifespan in mice" @default.
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• W3199355525 doi "https://doi.org/10.1111/acel.13479" @default.
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