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- W3199367631 abstract "<h3>Introduction</h3> The Nobel Prize winning discovery of Helicobacter Pylori in 1983 heralded a seismic shift in the treatment of peptic ulcer disease. Currently, NICE recommended a PPI, amoxicillin and clarithromycin or metronidazole as the 1st line eradication regimen for H.Pylori. Resistance rates against this regimen for the UK are not known but it is widely held that 1st line eradication is highly effective in clearing H. Pylori. We tested this hypothesis in our local population. <h3>Methods</h3> From April 2018 to March 2019, we commenced routine follow up testing 6–8 weeks post eradication with Helicobacter breath testing and performed a retrospective analysis of clearance rates. This was undertaken using online hospital records and the analysis performed using Microsoft Excel. <h3>Results</h3> 113 patients were identified who attended for follow up H. Pylori breath testing following first line eradication treatment. Of these, 63 (57.2%) returned negative tests and 47 (42.7%) returned positive breath tests. <h3>Conclusions</h3> A failure rate of 42.7% was far higher than expected for our local population and as a result we have held discussions with the Microbiology department and are in the process of altering the first line treatment to improve eradication. This is particularly important given that H. Pylori is now a WHO recognised carcinogen for gastric carcinoma. We are undertaking further analyses on the antibiotic exposure and demographic make-up of the population studied. We suspect that this level of resistance will be similar across the UK but further evidence from other sites is required to prove this." @default.
- W3199367631 created "2021-09-27" @default.
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- W3199367631 date "2021-01-01" @default.
- W3199367631 modified "2023-09-29" @default.
- W3199367631 title "P248 Helicobacter – are we losing the battle?" @default.
- W3199367631 doi "https://doi.org/10.1136/gutjnl-2020-bsgcampus.322" @default.
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