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- W3199374230 abstract "Abstract Background Microbes threaten human health in space exploration. Studies have shown that P. mirabilis has been found in human space habitats. In addition, the biological characteristics of P. mirabilis in space have been studied unconditionally. The simulated microgravity environment provides a platform for understanding the changes in the biological characteristics of P. mirabilis . Objective This study intends to explore the effect of simulated microgravity on P. mirabilis , the formation of P. mirabilis biofilm and its related mechanism. Methods The strange deformable rods were cultured continuously for 14 days under the microgravity simulated by (HARVs) in a high-aspect ratio vessels. The morphology, growth rate, metabolism and biofilm formation of the strain were measured, and the phenotypic changes of P. mirabilis were evaluated. Transcriptome sequencing was used to detect differentially expressed genes under simulated microgravity and compared with phenotype. Results The growth rate, metabolic ability and biofilm forming ability of P. mirabilis were lower than those of normal gravity culture under the condition of simulated microgravity. Further analysis showed that the decrease of growth rate, metabolic ability and biofilm forming ability may be caused by the down-regulation of related genes ( pstS,sodB and fumC ). Conclusion It provides a certain reference for the prevention and treatment of P. mirabilis infection in the future space station by exploring the effect of simulated microgravity exposure on P. mirabilis ." @default.
- W3199374230 created "2021-09-27" @default.
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- W3199374230 date "2021-04-09" @default.
- W3199374230 modified "2023-10-12" @default.
- W3199374230 title "Decreased biofilm formation in Proteus mirabilis after short-term exposure to a simulated microgravity environment" @default.
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- W3199374230 doi "https://doi.org/10.1101/2021.04.07.438892" @default.
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