FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199382289> ?p ?o ?g. }

• W3199382289 abstract "Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Our data demonstrated that ozone induced substantial ATP release from human airway epithelia in vitro and into the airways of mice in vivo and that ATP served as a potent inducer of mast cell degranulation and BHR, acting through P2X7 receptors on mast cells. Both mast cell-deficient and P2X7 receptor-deficient (P2X7-/-) mice demonstrated markedly attenuated BHR to ozone. Reconstitution of mast cell-deficient mice with WT mast cells and P2X7-/- mast cells restored ozone-induced BHR. Despite equal numbers of mast cells in reconstituted mouse lungs, mice reconstituted with P2X7-/- mast cells demonstrated significantly less robust BHR than mice reconstituted with WT mast cells. These results support a model where P2X7 on mast cells and other cell types contribute to ozone-induced BHR." @default.
• W3199382289 created "2021-09-27" @default.
• W3199382289 creator A5002379615 @default.
• W3199382289 creator A5003086485 @default.
• W3199382289 creator A5007960392 @default.
• W3199382289 creator A5008466775 @default.
• W3199382289 creator A5017306270 @default.
• W3199382289 creator A5035044136 @default.
• W3199382289 creator A5037088741 @default.
• W3199382289 creator A5038195431 @default.
• W3199382289 creator A5040257436 @default.
• W3199382289 creator A5044617284 @default.
• W3199382289 creator A5045957485 @default.
• W3199382289 creator A5049641668 @default.
• W3199382289 creator A5055711492 @default.
• W3199382289 creator A5057493550 @default.
• W3199382289 creator A5057646994 @default.
• W3199382289 creator A5059805278 @default.
• W3199382289 creator A5060861164 @default.
• W3199382289 creator A5071792755 @default.
• W3199382289 creator A5074376104 @default.
• W3199382289 date "2021-11-08" @default.
• W3199382289 modified "2023-10-12" @default.
• W3199382289 title "Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness" @default.
• W3199382289 cites W115423185 @default.
• W3199382289 cites W1527504008 @default.
• W3199382289 cites W1540927713 @default.
• W3199382289 cites W18245667 @default.
• W3199382289 cites W1866553628 @default.
• W3199382289 cites W1959276012 @default.
• W3199382289 cites W1971505855 @default.
• W3199382289 cites W1980539060 @default.
• W3199382289 cites W1982195979 @default.
• W3199382289 cites W2006104784 @default.
• W3199382289 cites W2008037195 @default.
• W3199382289 cites W2012526235 @default.
• W3199382289 cites W2024395201 @default.
• W3199382289 cites W2027394589 @default.
• W3199382289 cites W2041087647 @default.
• W3199382289 cites W2048300333 @default.
• W3199382289 cites W2053225881 @default.
• W3199382289 cites W2070649129 @default.
• W3199382289 cites W2077712485 @default.
• W3199382289 cites W2077747679 @default.
• W3199382289 cites W2089597910 @default.
• W3199382289 cites W2096086701 @default.
• W3199382289 cites W2103304921 @default.
• W3199382289 cites W2105407937 @default.
• W3199382289 cites W2106301295 @default.
• W3199382289 cites W2112100441 @default.
• W3199382289 cites W2119142540 @default.
• W3199382289 cites W2151507008 @default.
• W3199382289 cites W2155612793 @default.
• W3199382289 cites W2159938460 @default.
• W3199382289 cites W2164746237 @default.
• W3199382289 cites W2178148472 @default.
• W3199382289 cites W2281069839 @default.
• W3199382289 cites W2336447626 @default.
• W3199382289 cites W2349901624 @default.
• W3199382289 cites W2468258931 @default.
• W3199382289 cites W2474973387 @default.
• W3199382289 cites W2496073802 @default.
• W3199382289 cites W2503425081 @default.
• W3199382289 cites W2565268103 @default.
• W3199382289 cites W2776201877 @default.
• W3199382289 cites W2783448862 @default.
• W3199382289 cites W2883547282 @default.
• W3199382289 cites W2921695473 @default.
• W3199382289 cites W2936399322 @default.
• W3199382289 cites W2943402416 @default.
• W3199382289 cites W2949266051 @default.
• W3199382289 cites W2981191564 @default.
• W3199382289 cites W2992776058 @default.
• W3199382289 cites W3170738909 @default.
• W3199382289 cites W4247766106 @default.
• W3199382289 doi "https://doi.org/10.1172/jci.insight.140207" @default.
• W3199382289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34546976" @default.
• W3199382289 hasPublicationYear "2021" @default.
• W3199382289 type Work @default.
• W3199382289 sameAs 3199382289 @default.
• W3199382289 citedByCount "3" @default.
• W3199382289 countsByYear W31993822892022 @default.
• W3199382289 countsByYear W31993822892023 @default.
• W3199382289 crossrefType "journal-article" @default.
• W3199382289 hasAuthorship W3199382289A5002379615 @default.
• W3199382289 hasAuthorship W3199382289A5003086485 @default.
• W3199382289 hasAuthorship W3199382289A5007960392 @default.
• W3199382289 hasAuthorship W3199382289A5008466775 @default.
• W3199382289 hasAuthorship W3199382289A5017306270 @default.
• W3199382289 hasAuthorship W3199382289A5035044136 @default.
• W3199382289 hasAuthorship W3199382289A5037088741 @default.
• W3199382289 hasAuthorship W3199382289A5038195431 @default.
• W3199382289 hasAuthorship W3199382289A5040257436 @default.
• W3199382289 hasAuthorship W3199382289A5044617284 @default.
• W3199382289 hasAuthorship W3199382289A5045957485 @default.
• W3199382289 hasAuthorship W3199382289A5049641668 @default.
• W3199382289 hasAuthorship W3199382289A5055711492 @default.
• W3199382289 hasAuthorship W3199382289A5057493550 @default.
• W3199382289 hasAuthorship W3199382289A5057646994 @default.
• W3199382289 hasAuthorship W3199382289A5059805278 @default.

• next