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- W3199389638 abstract "The mortality risk of coronavirus disease 2019 (COVID-19) patients has been linked to the cytokine storm caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding the inflammatory responses shared between COVID-19 and other infectious diseases that feature cytokine storms may therefore help in developing improved therapeutic strategies. Here, we use integrative analysis of single-cell transcriptomes to characterize the inflammatory signatures of peripheral blood mononuclear cells from patients with COVID-19, sepsis, and HIV infection. We identify ten hyperinflammatory cell subtypes in which monocytes are the main contributors to the transcriptional differences in these infections. Monocytes from COVID-19 patients share hyperinflammatory signatures with HIV infection and immunosuppressive signatures with sepsis. Finally, we construct a three-stage model of heterogeneity among COVID-19 patients, related to the hyperinflammatory and immunosuppressive signatures in monocytes. Our study thus reveals cellular and molecular insights about inflammatory responses to SARS-CoV-2 infection and provides therapeutic guidance to improve treatments for subsets of COVID-19 patients." @default.
- W3199389638 created "2021-09-27" @default.
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- W3199389638 date "2021-10-01" @default.
- W3199389638 modified "2023-10-15" @default.
- W3199389638 title "Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes" @default.
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- W3199389638 doi "https://doi.org/10.1016/j.celrep.2021.109793" @default.
- W3199389638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8445774" @default.
- W3199389638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34587478" @default.
- W3199389638 hasPublicationYear "2021" @default.
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