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• W3199389719 startingPage "1193" @default.
• W3199389719 abstract "Although various new drugs have been developed, the prognosis of therapeutic advances for metastatic gastric cancer is insufficient. Trastuzumab deruxtecan (T-DXd), a new human epidermal growth factor receptor 2 (HER2)-targeting antibody-drug conjugate (ADC), has demonstrated promising results in clinical trials.In this article, we review the history of anti-HER2 ADCs and focus on the efficacy and safety of T-DXd and describe the development of new anti-HER2 drugs.So far, no other anti-HER2 ADCs have demonstrated efficacy in patients with HER2-positive advanced gastric cancer with two or more previous lines of chemotherapy, including trastuzumab. However, a new drug, T-DXd, has shown a significantly higher objective response rate and a longer overall survival and, thus, was approved in Japan. In the future, new anti-HER2 drugs and/or treatment strategies including T-DXd along with cytotoxic chemotherapy or immune checkpoint inhibitors will be developed." @default.
• W3199389719 created "2021-09-27" @default.
• W3199389719 creator A5015799240 @default.
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• W3199389719 date "2021-09-29" @default.
• W3199389719 modified "2023-09-23" @default.
• W3199389719 title "Trastuzumab deruxtecan and other HER2-targeting agents for the treatment of HER2-positive gastric cancer" @default.
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• W3199389719 doi "https://doi.org/10.1080/14737140.2021.1982698" @default.
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