FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199406458> ?p ?o ?g. }

• W3199406458 endingPage "7846" @default.
• W3199406458 startingPage "7831" @default.
• W3199406458 abstract "Abstract The role of B7 ‐ H3 in acute myeloid leukemia (AML) is not fully understood. Two previous studies investigating its expression and significances in AML are partially different. In this study, we aimed to systematically characterize the genomic and immune landscape in AML patients with altered B7 ‐ H3 expression using multi‐omics data in the public domain. We found significantly increased B7 ‐ H3 expression in AML compared to either other hematological malignancies or healthy controls. Clinically, high B7 ‐ H3 expression was associated with old age, TP53 mutations, wild‐type WT1 and CEBPA , and the M3 and M5 FAB subtypes. Moreover, we observed that increased B7 ‐ H3 expression correlated significantly with a poor outcome of AML patients in four independent datasets. Gene set enrichment analysis (GSEA) revealed the enrichment of the “EMT” oncogenic gene signatures in high B7 ‐ H3 expressers. Further investigation suggested that B7 ‐ H3 was more likely to be associated with immune‐suppressive cells (macrophages, neutrophils, dendritic cells, and Th17 cells). B7 ‐ H3 was also positively associated with a number of checkpoint genes, such as VISTA ( B7 ‐ H5 ), CD80 ( B7 ‐ 1 ), CD86 ( B7 ‐ 2 ), and CD70 . In summary, we uncovered distinct genomic and immunologic features associated with B7 ‐ H3 expression in AML. This may lead to a better understanding of the molecular mechanisms underlying B7 ‐ H3 dysregulation in AML and to the development of novel therapeutic strategies." @default.
• W3199406458 created "2021-09-27" @default.
• W3199406458 creator A5004231241 @default.
• W3199406458 creator A5008118059 @default.
• W3199406458 creator A5014048532 @default.
• W3199406458 creator A5015642582 @default.
• W3199406458 creator A5018404473 @default.
• W3199406458 creator A5020923032 @default.
• W3199406458 creator A5037332032 @default.
• W3199406458 creator A5040442106 @default.
• W3199406458 creator A5047951366 @default.
• W3199406458 creator A5061817335 @default.
• W3199406458 creator A5072354292 @default.
• W3199406458 creator A5084645019 @default.
• W3199406458 date "2021-09-25" @default.
• W3199406458 modified "2023-10-15" @default.
• W3199406458 title "Integrated analysis reveals distinct molecular, clinical, and immunological features of <i>B7‐H3</i> in acute myeloid leukemia" @default.
• W3199406458 cites W1698721454 @default.
• W3199406458 cites W1717716318 @default.
• W3199406458 cites W1778360744 @default.
• W3199406458 cites W1966107523 @default.
• W3199406458 cites W1973765711 @default.
• W3199406458 cites W1985987855 @default.
• W3199406458 cites W1997133557 @default.
• W3199406458 cites W2000959092 @default.
• W3199406458 cites W2011182234 @default.
• W3199406458 cites W2033323727 @default.
• W3199406458 cites W2037900813 @default.
• W3199406458 cites W2040159457 @default.
• W3199406458 cites W204284564 @default.
• W3199406458 cites W2052644931 @default.
• W3199406458 cites W2082028734 @default.
• W3199406458 cites W2101653483 @default.
• W3199406458 cites W2114104545 @default.
• W3199406458 cites W2115242278 @default.
• W3199406458 cites W2121934915 @default.
• W3199406458 cites W2123879591 @default.
• W3199406458 cites W2139036808 @default.
• W3199406458 cites W2146512944 @default.
• W3199406458 cites W2147878409 @default.
• W3199406458 cites W2151950981 @default.
• W3199406458 cites W2157852151 @default.
• W3199406458 cites W2159707944 @default.
• W3199406458 cites W2160834915 @default.
• W3199406458 cites W2164079212 @default.
• W3199406458 cites W2172178818 @default.
• W3199406458 cites W2257916459 @default.
• W3199406458 cites W2550291749 @default.
• W3199406458 cites W2551911481 @default.
• W3199406458 cites W2560367415 @default.
• W3199406458 cites W2587048937 @default.
• W3199406458 cites W2613336296 @default.
• W3199406458 cites W2733520933 @default.
• W3199406458 cites W2758173690 @default.
• W3199406458 cites W2896872272 @default.
• W3199406458 cites W2903182084 @default.
• W3199406458 cites W2905562353 @default.
• W3199406458 cites W2925929837 @default.
• W3199406458 cites W2949273159 @default.
• W3199406458 cites W2954592222 @default.
• W3199406458 cites W2984876778 @default.
• W3199406458 cites W3040089074 @default.
• W3199406458 cites W3199406458 @default.
• W3199406458 doi "https://doi.org/10.1002/cam4.4284" @default.
• W3199406458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8559480" @default.
• W3199406458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34562306" @default.
• W3199406458 hasPublicationYear "2021" @default.
• W3199406458 type Work @default.
• W3199406458 sameAs 3199406458 @default.
• W3199406458 citedByCount "8" @default.
• W3199406458 countsByYear W31994064582021 @default.
• W3199406458 countsByYear W31994064582022 @default.
• W3199406458 countsByYear W31994064582023 @default.
• W3199406458 crossrefType "journal-article" @default.
• W3199406458 hasAuthorship W3199406458A5004231241 @default.
• W3199406458 hasAuthorship W3199406458A5008118059 @default.
• W3199406458 hasAuthorship W3199406458A5014048532 @default.
• W3199406458 hasAuthorship W3199406458A5015642582 @default.
• W3199406458 hasAuthorship W3199406458A5018404473 @default.
• W3199406458 hasAuthorship W3199406458A5020923032 @default.
• W3199406458 hasAuthorship W3199406458A5037332032 @default.
• W3199406458 hasAuthorship W3199406458A5040442106 @default.
• W3199406458 hasAuthorship W3199406458A5047951366 @default.
• W3199406458 hasAuthorship W3199406458A5061817335 @default.
• W3199406458 hasAuthorship W3199406458A5072354292 @default.
• W3199406458 hasAuthorship W3199406458A5084645019 @default.
• W3199406458 hasBestOaLocation W31994064583 @default.
• W3199406458 hasConcept C104317684 @default.
• W3199406458 hasConcept C150194340 @default.
• W3199406458 hasConcept C154317977 @default.
• W3199406458 hasConcept C18431079 @default.
• W3199406458 hasConcept C202751555 @default.
• W3199406458 hasConcept C203014093 @default.
• W3199406458 hasConcept C2776090121 @default.
• W3199406458 hasConcept C2778297628 @default.
• W3199406458 hasConcept C2778461978 @default.
• W3199406458 hasConcept C2778729363 @default.
• W3199406458 hasConcept C2779282312 @default.

• next