Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199419849> ?p ?o ?g. }
- W3199419849 abstract "Exposure to infection in utero predisposes towards psychiatric diseases such as autism, depression and schizophrenia in later life. The mechanisms involved are typically studied by administering mimetics of double-stranded (ds) RNA viral or bacterial infection to pregnant rats or mice. The effect of single-stranded (ss) virus mimetics has been largely ignored, despite evidence linking prenatal ss virus exposure specifically with psychiatric disease. Understanding the effects of gestational ss virus exposure has become even more important with the current SARS-CoV-2 pandemic. In this study, in pregnant mice, we compare directly the effects, on the maternal blood, placenta and the embryonic brain, of maternal administration of ds-virus mimetic poly I:C (to activate toll-like receptor 3, TLR3) and ss-virus mimetic resiquimod (to activate TLR7/8). We find that, 4h after the administration, both poly I:C and resiquimod elevated the levels of IL-6, TNFa, and chemokines including CCL2 and CCL5, in maternal plasma. Both agents also increased placental mRNA levels of IL-6 and IL-10, but only resiquimod increased placental TNFa mRNA. In foetal brain, poly I:C produced no detectable immune-response-related increases, whereas pronounced increases in cytokine (e.g. Il-6, Tnfa, and chemokine (e.g. Ccl2, Ccl5) expression were observed with maternal resiquimod administration. The data show substantial differences between the effect of maternal exposure to a TLR7/8 activator as compared to a TLR3 activator. There are significant implications for future modelling of diseases where maternal ss virus exposure contributes to environmental disease risk in offspring." @default.
- W3199419849 created "2021-09-27" @default.
- W3199419849 creator A5007991187 @default.
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- W3199419849 creator A5013772238 @default.
- W3199419849 creator A5047863656 @default.
- W3199419849 creator A5051898396 @default.
- W3199419849 date "2021-09-21" @default.
- W3199419849 modified "2023-10-17" @default.
- W3199419849 title "Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk" @default.
- W3199419849 cites W1485248315 @default.
- W3199419849 cites W1502575492 @default.
- W3199419849 cites W1590854724 @default.
- W3199419849 cites W1597606892 @default.
- W3199419849 cites W1914782230 @default.
- W3199419849 cites W1964007647 @default.
- W3199419849 cites W1966407955 @default.
- W3199419849 cites W1970216950 @default.
- W3199419849 cites W1970279912 @default.
- W3199419849 cites W1972776583 @default.
- W3199419849 cites W1974003946 @default.
- W3199419849 cites W1978629444 @default.
- W3199419849 cites W1989339029 @default.
- W3199419849 cites W1990628692 @default.
- W3199419849 cites W1990999239 @default.
- W3199419849 cites W1994600097 @default.
- W3199419849 cites W1996790111 @default.
- W3199419849 cites W1999952543 @default.
- W3199419849 cites W2004317605 @default.
- W3199419849 cites W2005989827 @default.
- W3199419849 cites W2014944455 @default.
- W3199419849 cites W2019500286 @default.
- W3199419849 cites W2026241317 @default.
- W3199419849 cites W2037827983 @default.
- W3199419849 cites W2038982445 @default.
- W3199419849 cites W2040408325 @default.
- W3199419849 cites W2041812587 @default.
- W3199419849 cites W2041955098 @default.
- W3199419849 cites W2042914870 @default.
- W3199419849 cites W2043419028 @default.
- W3199419849 cites W2049993412 @default.
- W3199419849 cites W2052297858 @default.
- W3199419849 cites W2054005457 @default.
- W3199419849 cites W2061671382 @default.
- W3199419849 cites W2068766837 @default.
- W3199419849 cites W2070936810 @default.
- W3199419849 cites W2071753918 @default.
- W3199419849 cites W2076644456 @default.
- W3199419849 cites W2082955509 @default.
- W3199419849 cites W2087771052 @default.
- W3199419849 cites W2090407590 @default.
- W3199419849 cites W2092196742 @default.
- W3199419849 cites W2104431737 @default.
- W3199419849 cites W2105035544 @default.
- W3199419849 cites W2105764831 @default.
- W3199419849 cites W2105793163 @default.
- W3199419849 cites W2113207193 @default.
- W3199419849 cites W2113295282 @default.
- W3199419849 cites W2117723028 @default.
- W3199419849 cites W2119353857 @default.
- W3199419849 cites W2119783889 @default.
- W3199419849 cites W2124667416 @default.
- W3199419849 cites W2124836944 @default.
- W3199419849 cites W2125343575 @default.
- W3199419849 cites W2127008679 @default.
- W3199419849 cites W2137876530 @default.
- W3199419849 cites W2142392174 @default.
- W3199419849 cites W2142972284 @default.
- W3199419849 cites W2144604423 @default.
- W3199419849 cites W2148898943 @default.
- W3199419849 cites W2151841070 @default.
- W3199419849 cites W2159017912 @default.
- W3199419849 cites W2163487275 @default.
- W3199419849 cites W2165444002 @default.
- W3199419849 cites W2166351804 @default.
- W3199419849 cites W2280077905 @default.
- W3199419849 cites W2345399978 @default.
- W3199419849 cites W2414611204 @default.
- W3199419849 cites W2515897135 @default.
- W3199419849 cites W2549204228 @default.
- W3199419849 cites W2553830639 @default.
- W3199419849 cites W2579686155 @default.
- W3199419849 cites W2588193271 @default.
- W3199419849 cites W2706585816 @default.
- W3199419849 cites W2746090598 @default.
- W3199419849 cites W2781294921 @default.
- W3199419849 cites W2788734919 @default.
- W3199419849 cites W2804756252 @default.
- W3199419849 cites W2885203079 @default.
- W3199419849 cites W2890708734 @default.
- W3199419849 cites W2891901614 @default.
- W3199419849 cites W2892154404 @default.
- W3199419849 cites W2907227651 @default.
- W3199419849 cites W2913221496 @default.
- W3199419849 cites W2917356768 @default.
- W3199419849 cites W2922106290 @default.
- W3199419849 cites W2929370075 @default.
- W3199419849 cites W2938147577 @default.
- W3199419849 cites W2940307136 @default.
- W3199419849 cites W2952811277 @default.