FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199429123> ?p ?o ?g. }

• W3199429123 abstract "Abstract The H1N1 pandemic in 2009 and the H5N1 outbreak in 2005 have shocked the world as millions of people were infected and hundreds of thousands died due to the infections by the influenza virus. Oseltamivir, the most common drug to block the viral life cycle by inhibiting neuraminidase (NA) enzyme, has been less effective in some resistant cases due to the virus mutation. Presently, the binding of 10 chalcone derivatives towards H5N1 and H1N1 NAs in the non-catalytic and catalytic sites was studied using molecular docking. The in silico study was also conducted for its drug-like likeness such as Lipinski Rule, mutagenicity, toxicity and pharmacokinetic profiles. The result demonstrates that two chalcones ( 1c and 2b ) have the potential for future NA inhibitor development. Compound 1c inhibits H5N1 NA and H1N1 NA with IC 50 of 27.63 µM and 28.11 µM, respectively, whereas compound 2b inhibits NAs with IC 50 of 87.54 µM and 73.17 µM for H5N1 and H1N1, respectively. The in silico drug-like likeness prediction reveals that 1c is 62% better than 2b (58%) in meeting the criteria. The results suggested that 1c and 2b have potencies to be developed as non-competitive inhibitors of neuraminidase for the future development of anti-influenza drugs." @default.
• W3199429123 created "2021-09-27" @default.
• W3199429123 creator A5008474034 @default.
• W3199429123 creator A5026754897 @default.
• W3199429123 creator A5031521272 @default.
• W3199429123 creator A5049825838 @default.
• W3199429123 creator A5076078497 @default.
• W3199429123 creator A5090318943 @default.
• W3199429123 creator A5091768113 @default.
• W3199429123 date "2021-09-17" @default.
• W3199429123 modified "2023-09-25" @default.
• W3199429123 title "A study on catalytic and non-catalytic sites of H5N1 and H1N1 neuraminidase as the target for chalcone inhibitors" @default.
• W3199429123 cites W1257546274 @default.
• W3199429123 cites W128151115 @default.
• W3199429123 cites W1494809548 @default.
• W3199429123 cites W1511143898 @default.
• W3199429123 cites W1521274794 @default.
• W3199429123 cites W1575475388 @default.
• W3199429123 cites W1591275796 @default.
• W3199429123 cites W1966050415 @default.
• W3199429123 cites W1971684204 @default.
• W3199429123 cites W1975608032 @default.
• W3199429123 cites W1988044361 @default.
• W3199429123 cites W1994644330 @default.
• W3199429123 cites W1995967240 @default.
• W3199429123 cites W2000562852 @default.
• W3199429123 cites W2004503172 @default.
• W3199429123 cites W2009867031 @default.
• W3199429123 cites W2011607869 @default.
• W3199429123 cites W2012915017 @default.
• W3199429123 cites W2026262004 @default.
• W3199429123 cites W2035029050 @default.
• W3199429123 cites W2042325760 @default.
• W3199429123 cites W2043857517 @default.
• W3199429123 cites W2046745698 @default.
• W3199429123 cites W2050205112 @default.
• W3199429123 cites W2062871281 @default.
• W3199429123 cites W2065420324 @default.
• W3199429123 cites W2069506489 @default.
• W3199429123 cites W2071128290 @default.
• W3199429123 cites W2072369556 @default.
• W3199429123 cites W2074530679 @default.
• W3199429123 cites W2079685721 @default.
• W3199429123 cites W2090632754 @default.
• W3199429123 cites W2092528857 @default.
• W3199429123 cites W2135814560 @default.
• W3199429123 cites W2146917216 @default.
• W3199429123 cites W2156796649 @default.
• W3199429123 cites W2212345909 @default.
• W3199429123 cites W2212856146 @default.
• W3199429123 cites W2309887917 @default.
• W3199429123 cites W2329275382 @default.
• W3199429123 cites W2412876393 @default.
• W3199429123 cites W2413938120 @default.
• W3199429123 cites W2483141331 @default.
• W3199429123 cites W2488422601 @default.
• W3199429123 cites W2508071059 @default.
• W3199429123 cites W2563887382 @default.
• W3199429123 cites W2945917367 @default.
• W3199429123 cites W2970196665 @default.
• W3199429123 cites W3002108456 @default.
• W3199429123 cites W3092668553 @default.
• W3199429123 cites W3168000110 @default.
• W3199429123 cites W4231421929 @default.
• W3199429123 cites W4239761798 @default.
• W3199429123 cites W4245153646 @default.
• W3199429123 cites W2992689342 @default.
• W3199429123 doi "https://doi.org/10.1186/s13765-021-00639-w" @default.
• W3199429123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8445792" @default.
• W3199429123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34549099" @default.
• W3199429123 hasPublicationYear "2021" @default.
• W3199429123 type Work @default.
• W3199429123 sameAs 3199429123 @default.
• W3199429123 citedByCount "4" @default.
• W3199429123 countsByYear W31994291232022 @default.
• W3199429123 countsByYear W31994291232023 @default.
• W3199429123 crossrefType "journal-article" @default.
• W3199429123 hasAuthorship W3199429123A5008474034 @default.
• W3199429123 hasAuthorship W3199429123A5026754897 @default.
• W3199429123 hasAuthorship W3199429123A5031521272 @default.
• W3199429123 hasAuthorship W3199429123A5049825838 @default.
• W3199429123 hasAuthorship W3199429123A5076078497 @default.
• W3199429123 hasAuthorship W3199429123A5090318943 @default.
• W3199429123 hasAuthorship W3199429123A5091768113 @default.
• W3199429123 hasBestOaLocation W31994291231 @default.
• W3199429123 hasConcept C104317684 @default.
• W3199429123 hasConcept C134164806 @default.
• W3199429123 hasConcept C142724271 @default.
• W3199429123 hasConcept C159047783 @default.
• W3199429123 hasConcept C181199279 @default.
• W3199429123 hasConcept C185592680 @default.
• W3199429123 hasConcept C2522874641 @default.
• W3199429123 hasConcept C2775905019 @default.
• W3199429123 hasConcept C2777538117 @default.
• W3199429123 hasConcept C2777546802 @default.
• W3199429123 hasConcept C2779134260 @default.
• W3199429123 hasConcept C2780374985 @default.
• W3199429123 hasConcept C2780764945 @default.
• W3199429123 hasConcept C3008058167 @default.
• W3199429123 hasConcept C41847442 @default.

• next