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- W3199441485 abstract "Transforming growth factor-β (TGF-β) plays important roles in wound healing. The activity of TGF-β is initiated upon binding of the growth factor to extracellular domains of its receptors. We sought to facilitate activation by clustering these extracellular domains. To do so, we used a known peptide that binds to TGF-β receptors without diminishing their affinity for TGF-β. We conjugated this peptide to a collagen-mimetic peptide that can anneal to damaged collagen in a wound bed. We find that the conjugate enhances collagen deposition and wound closure in mice in a manner consistent with the clustering of TGF-β receptors. This strategy provides a means to upregulate the TGF-β signaling pathway without adding exogenous TGF-β and could inspire means to treat severe wounds." @default.
- W3199441485 created "2021-09-27" @default.
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- W3199441485 date "2021-09-23" @default.
- W3199441485 modified "2023-10-16" @default.
- W3199441485 title "Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing" @default.
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- W3199441485 doi "https://doi.org/10.1101/2021.09.22.461420" @default.
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