FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199443487> ?p ?o ?g. }

• W3199443487 endingPage "e0257375" @default.
• W3199443487 startingPage "e0257375" @default.
• W3199443487 abstract "Radiation therapy is among the most essential treatment methods for glioblastoma multiforme (GBM). Radio-resistance and cancer stem cell properties can cause therapeutic resistance, cancer heterogeneity, and poor prognoses in association with GBM. Furthermore, the GBM subtype transition from proneural to the most malignant mesenchymal subtype after radiation therapy also accounts for high resistance to conventional treatments. Here, we demonstrate that the inhibition of macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) by 4-iodo-6-phenylpyrimidine (4-IPP), a dual inhibitor targeting MIF and DDT, downregulates stemness phenotype, intracellular signaling cascades, mesenchymal trans-differentiation, and induces apoptosis in proneural glioma stem cells (GSCs). In an analysis of The Cancer Genome Atlas, high MIF and DDT expression were associated with poor prognosis. GSC growth was effectively inhibited by 4-IPP in a time- and dose-dependent manner, and 4-IPP combined with radiation therapy led to significantly reduced proliferation compared with radiation therapy alone. The expression of stemness factors, such as Olig2 and SOX2, and the expression of pAKT, indicating PI3K signaling pathway activation, were decreased in association with both 4-IPP monotherapy and combination treatment. The expression of mesenchymal markers, TGM2 and NF-κB, and expression of pERK (indicating MAPK signaling pathway activation) increased in association with radiation therapy alone but not with 4-IPP monotherapy and combination therapy. In addition, the combination of 4-IPP and radiation therapy significantly induced apoptosis compared to the monotherapy of 4-IPP or radiation. In vivo results demonstrated a significant tumor-suppressing effect of 4-IPP when combined with radiation therapy. Collectively, our results showed that the targeted inhibition of MIF and DDT has the potential to strengthen current clinical strategies by enhancing the anticancer effects of radiation therapy." @default.
• W3199443487 created "2021-09-27" @default.
• W3199443487 creator A5008844274 @default.
• W3199443487 creator A5011856967 @default.
• W3199443487 creator A5012945820 @default.
• W3199443487 creator A5025722673 @default.
• W3199443487 creator A5036122648 @default.
• W3199443487 creator A5058516635 @default.
• W3199443487 creator A5079528300 @default.
• W3199443487 creator A5081182102 @default.
• W3199443487 date "2021-09-13" @default.
• W3199443487 modified "2023-09-29" @default.
• W3199443487 title "Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme" @default.
• W3199443487 cites W1963807870 @default.
• W3199443487 cites W1984262875 @default.
• W3199443487 cites W1986525049 @default.
• W3199443487 cites W2007263630 @default.
• W3199443487 cites W2024672608 @default.
• W3199443487 cites W2035626890 @default.
• W3199443487 cites W2036044314 @default.
• W3199443487 cites W2039765839 @default.
• W3199443487 cites W2047308155 @default.
• W3199443487 cites W2048467313 @default.
• W3199443487 cites W2083244808 @default.
• W3199443487 cites W2113293014 @default.
• W3199443487 cites W2115681156 @default.
• W3199443487 cites W2144169031 @default.
• W3199443487 cites W2225413809 @default.
• W3199443487 cites W2252688218 @default.
• W3199443487 cites W2288737104 @default.
• W3199443487 cites W2302052593 @default.
• W3199443487 cites W2325707043 @default.
• W3199443487 cites W2346941018 @default.
• W3199443487 cites W2495344921 @default.
• W3199443487 cites W2519554108 @default.
• W3199443487 cites W2567410567 @default.
• W3199443487 cites W2585659713 @default.
• W3199443487 cites W2595356781 @default.
• W3199443487 cites W2606513998 @default.
• W3199443487 cites W2620951925 @default.
• W3199443487 cites W2740108964 @default.
• W3199443487 cites W2806216257 @default.
• W3199443487 cites W2900254393 @default.
• W3199443487 cites W2914093530 @default.
• W3199443487 cites W2934620676 @default.
• W3199443487 cites W2946572822 @default.
• W3199443487 cites W2948685705 @default.
• W3199443487 cites W3028304854 @default.
• W3199443487 doi "https://doi.org/10.1371/journal.pone.0257375" @default.
• W3199443487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8437287" @default.
• W3199443487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34516577" @default.
• W3199443487 hasPublicationYear "2021" @default.
• W3199443487 type Work @default.
• W3199443487 sameAs 3199443487 @default.
• W3199443487 citedByCount "6" @default.
• W3199443487 countsByYear W31994434872022 @default.
• W3199443487 countsByYear W31994434872023 @default.
• W3199443487 crossrefType "journal-article" @default.
• W3199443487 hasAuthorship W3199443487A5008844274 @default.
• W3199443487 hasAuthorship W3199443487A5011856967 @default.
• W3199443487 hasAuthorship W3199443487A5012945820 @default.
• W3199443487 hasAuthorship W3199443487A5025722673 @default.
• W3199443487 hasAuthorship W3199443487A5036122648 @default.
• W3199443487 hasAuthorship W3199443487A5058516635 @default.
• W3199443487 hasAuthorship W3199443487A5079528300 @default.
• W3199443487 hasAuthorship W3199443487A5081182102 @default.
• W3199443487 hasBestOaLocation W31994434871 @default.
• W3199443487 hasConcept C104317684 @default.
• W3199443487 hasConcept C198826908 @default.
• W3199443487 hasConcept C2777933648 @default.
• W3199443487 hasConcept C2778227246 @default.
• W3199443487 hasConcept C28328180 @default.
• W3199443487 hasConcept C502942594 @default.
• W3199443487 hasConcept C55427017 @default.
• W3199443487 hasConcept C55493867 @default.
• W3199443487 hasConcept C86339819 @default.
• W3199443487 hasConcept C86803240 @default.
• W3199443487 hasConcept C95444343 @default.
• W3199443487 hasConceptScore W3199443487C104317684 @default.
• W3199443487 hasConceptScore W3199443487C198826908 @default.
• W3199443487 hasConceptScore W3199443487C2777933648 @default.
• W3199443487 hasConceptScore W3199443487C2778227246 @default.
• W3199443487 hasConceptScore W3199443487C28328180 @default.
• W3199443487 hasConceptScore W3199443487C502942594 @default.
• W3199443487 hasConceptScore W3199443487C55427017 @default.
• W3199443487 hasConceptScore W3199443487C55493867 @default.
• W3199443487 hasConceptScore W3199443487C86339819 @default.
• W3199443487 hasConceptScore W3199443487C86803240 @default.
• W3199443487 hasConceptScore W3199443487C95444343 @default.
• W3199443487 hasIssue "9" @default.
• W3199443487 hasLocation W31994434871 @default.
• W3199443487 hasLocation W31994434872 @default.
• W3199443487 hasLocation W31994434873 @default.
• W3199443487 hasOpenAccess W3199443487 @default.
• W3199443487 hasPrimaryLocation W31994434871 @default.
• W3199443487 hasRelatedWork W1990847810 @default.
• W3199443487 hasRelatedWork W1999155906 @default.
• W3199443487 hasRelatedWork W2009589877 @default.

• next