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- W3199473218 endingPage "4833" @default.
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- W3199473218 abstract "Biliary tract cancers (BTCs) consist of a group of highly heterogeneous malignancies that are characterized by genomic differences among tumors from different anatomic sites. The current treatment for BTC includes surgery, chemotherapy, target therapy, and immunotherapy. Although surgery remains the primary option for localized disease, representing the only potential curative treatment, a high risk of recurrence cannot be neglected. Chemotherapy has been considered the standard of care for both advanced and metastatic disease and in adjuvant settings. However, drug resistance is a major obstacle associated with chemotherapy. The development of genetic testing technologies, including next-generation sequencing, has opened the door for the identification of drug targets and candidate molecules. A series of preclinical studies has demonstrated the role of gene mutations, abnormal signaling pathways, and immunosuppression in the pathogenesis of BTC, laying the foundation for the application of targeted therapy and immunotherapy. A variety of molecularly targeted agents, including pemigatinib, have shown promising survival benefits in patients with advanced disease. The rapidly evolving role of multimodal therapy represents the subject of this review." @default.
- W3199473218 created "2021-09-27" @default.
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- W3199473218 date "2021-10-06" @default.
- W3199473218 modified "2023-10-05" @default.
- W3199473218 title "Emerging treatment evolutions and integrated molecular characteristics of biliary tract cancers" @default.
- W3199473218 cites W1486884945 @default.
- W3199473218 cites W1857263726 @default.
- W3199473218 cites W1891752511 @default.
- W3199473218 cites W1903979702 @default.
- W3199473218 cites W1966510389 @default.
- W3199473218 cites W1973268287 @default.
- W3199473218 cites W1991028289 @default.
- W3199473218 cites W2007555374 @default.
- W3199473218 cites W2008777301 @default.
- W3199473218 cites W2015613033 @default.
- W3199473218 cites W2018041848 @default.
- W3199473218 cites W2028640470 @default.
- W3199473218 cites W2033161279 @default.
- W3199473218 cites W2059634098 @default.
- W3199473218 cites W2062138514 @default.
- W3199473218 cites W2063515380 @default.
- W3199473218 cites W2067575315 @default.
- W3199473218 cites W2069828527 @default.
- W3199473218 cites W2106015641 @default.
- W3199473218 cites W2108756633 @default.
- W3199473218 cites W2111348064 @default.
- W3199473218 cites W2113222623 @default.
- W3199473218 cites W2115261608 @default.
- W3199473218 cites W2115781548 @default.
- W3199473218 cites W2148899606 @default.
- W3199473218 cites W2157232767 @default.
- W3199473218 cites W2310278114 @default.
- W3199473218 cites W2335155752 @default.
- W3199473218 cites W2337387091 @default.
- W3199473218 cites W2339653391 @default.
- W3199473218 cites W2403585105 @default.
- W3199473218 cites W2408652783 @default.
- W3199473218 cites W2413309626 @default.
- W3199473218 cites W2474141049 @default.
- W3199473218 cites W2479861471 @default.
- W3199473218 cites W2508622625 @default.
- W3199473218 cites W2523691892 @default.
- W3199473218 cites W2553739594 @default.
- W3199473218 cites W2554089088 @default.
- W3199473218 cites W257954806 @default.
- W3199473218 cites W2585601100 @default.
- W3199473218 cites W2587333476 @default.
- W3199473218 cites W2589049990 @default.
- W3199473218 cites W2607173021 @default.
- W3199473218 cites W2734751581 @default.
- W3199473218 cites W2752583521 @default.
- W3199473218 cites W2767231608 @default.
- W3199473218 cites W2769183729 @default.
- W3199473218 cites W2769404118 @default.
- W3199473218 cites W2769909737 @default.
- W3199473218 cites W2789901176 @default.
- W3199473218 cites W2790277876 @default.
- W3199473218 cites W2792688102 @default.
- W3199473218 cites W2795040138 @default.
- W3199473218 cites W2797072792 @default.
- W3199473218 cites W2805926640 @default.
- W3199473218 cites W2811258207 @default.
- W3199473218 cites W2889197632 @default.
- W3199473218 cites W2895929553 @default.
- W3199473218 cites W2899924640 @default.
- W3199473218 cites W2903993960 @default.
- W3199473218 cites W2914858130 @default.
- W3199473218 cites W2914985033 @default.
- W3199473218 cites W2916978683 @default.
- W3199473218 cites W2917680953 @default.
- W3199473218 cites W2919806338 @default.
- W3199473218 cites W2920983014 @default.
- W3199473218 cites W2921800388 @default.
- W3199473218 cites W2921963909 @default.
- W3199473218 cites W2923282967 @default.
- W3199473218 cites W2937317161 @default.
- W3199473218 cites W2941856415 @default.
- W3199473218 cites W2945968242 @default.
- W3199473218 cites W2946309206 @default.
- W3199473218 cites W2949307886 @default.
- W3199473218 cites W2952065098 @default.
- W3199473218 cites W2955212280 @default.
- W3199473218 cites W2972422665 @default.
- W3199473218 cites W2974350807 @default.
- W3199473218 cites W2977982707 @default.
- W3199473218 cites W2979343554 @default.
- W3199473218 cites W2984359187 @default.