FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199482607> ?p ?o ?g. }

• W3199482607 abstract "Early development of broadly neutralizing antibodies (bNAbs) targeting the hepatitis C virus (HCV) envelope glycoprotein E2 is associated with spontaneous clearance of infection, so induction of bNAbs is a major goal of HCV vaccine development. However, much remains to be learned at a molecular level about protective E2-specific antibodies, since HCV infection persists in some individuals despite early development of broadly neutralizing plasma. To examine B cell repertoire features associated with broad neutralization and viral clearance, we performed RNA sequencing of the B cell receptors (BCRs) of HCV E2-specific B cells of people with cleared or persistent HCV, including subjects with high or low plasma neutralizing breadth in both clearance and persistence groups. We identified many E2-specific public BCR clonotypes, which are antibody clones with the same V and J-genes and identical CDR3 sequences, shared among subjects grouped by either clearance or neutralization status. The majority (89) of these public clonotypes were shared by two subjects with broad plasma neutralizing activity and cleared infection, but not found in subjects with high plasma neutralizing breadth and persistent infection. We cloned a potent, cross-reactive neutralizing monoclonal antibody (mAb) by pairing the most abundant public heavy and light chains from these two subjects, providing evidence that broadly E2-reactive public clonotypes arise in a subset of individuals with broadly neutralizing plasma and spontaneous clearance of infection. Further characterization of the molecular features and function of these antibodies can inform HCV vaccine development." @default.
• W3199482607 created "2021-09-27" @default.
• W3199482607 creator A5002755631 @default.
• W3199482607 creator A5017393716 @default.
• W3199482607 creator A5023262306 @default.
• W3199482607 creator A5038760657 @default.
• W3199482607 creator A5041487849 @default.
• W3199482607 creator A5059153938 @default.
• W3199482607 creator A5084174098 @default.
• W3199482607 creator A5086896931 @default.
• W3199482607 creator A5091563687 @default.
• W3199482607 date "2021-09-21" @default.
• W3199482607 modified "2023-10-18" @default.
• W3199482607 title "Convergent antibody responses associated with broad neutralization of hepatitis C virus and clearance of infection" @default.
• W3199482607 cites W1569603086 @default.
• W3199482607 cites W1953340689 @default.
• W3199482607 cites W1963707175 @default.
• W3199482607 cites W1981136135 @default.
• W3199482607 cites W1985982900 @default.
• W3199482607 cites W1989058813 @default.
• W3199482607 cites W1990058709 @default.
• W3199482607 cites W2000835793 @default.
• W3199482607 cites W2012420380 @default.
• W3199482607 cites W2012873002 @default.
• W3199482607 cites W2017017909 @default.
• W3199482607 cites W2017359325 @default.
• W3199482607 cites W2071928914 @default.
• W3199482607 cites W2089041106 @default.
• W3199482607 cites W2090297731 @default.
• W3199482607 cites W2108927023 @default.
• W3199482607 cites W2126482091 @default.
• W3199482607 cites W2130742919 @default.
• W3199482607 cites W2131137764 @default.
• W3199482607 cites W2137929296 @default.
• W3199482607 cites W2143454433 @default.
• W3199482607 cites W2148099428 @default.
• W3199482607 cites W2169375105 @default.
• W3199482607 cites W2339016944 @default.
• W3199482607 cites W2591375730 @default.
• W3199482607 cites W2741725136 @default.
• W3199482607 cites W2801531265 @default.
• W3199482607 cites W2806630981 @default.
• W3199482607 cites W2900584247 @default.
• W3199482607 cites W2901354402 @default.
• W3199482607 cites W2910317080 @default.
• W3199482607 cites W2944248937 @default.
• W3199482607 cites W3133546543 @default.
• W3199482607 doi "https://doi.org/10.1101/2021.09.11.21263416" @default.
• W3199482607 hasPublicationYear "2021" @default.
• W3199482607 type Work @default.
• W3199482607 sameAs 3199482607 @default.
• W3199482607 citedByCount "0" @default.
• W3199482607 crossrefType "posted-content" @default.
• W3199482607 hasAuthorship W3199482607A5002755631 @default.
• W3199482607 hasAuthorship W3199482607A5017393716 @default.
• W3199482607 hasAuthorship W3199482607A5023262306 @default.
• W3199482607 hasAuthorship W3199482607A5038760657 @default.
• W3199482607 hasAuthorship W3199482607A5041487849 @default.
• W3199482607 hasAuthorship W3199482607A5059153938 @default.
• W3199482607 hasAuthorship W3199482607A5084174098 @default.
• W3199482607 hasAuthorship W3199482607A5086896931 @default.
• W3199482607 hasAuthorship W3199482607A5091563687 @default.
• W3199482607 hasBestOaLocation W31994826071 @default.
• W3199482607 hasConcept C126894567 @default.
• W3199482607 hasConcept C138944611 @default.
• W3199482607 hasConcept C14086860 @default.
• W3199482607 hasConcept C159047783 @default.
• W3199482607 hasConcept C159654299 @default.
• W3199482607 hasConcept C203014093 @default.
• W3199482607 hasConcept C2522874641 @default.
• W3199482607 hasConcept C2776408679 @default.
• W3199482607 hasConcept C2776507628 @default.
• W3199482607 hasConcept C2779261636 @default.
• W3199482607 hasConcept C542903549 @default.
• W3199482607 hasConcept C71924100 @default.
• W3199482607 hasConcept C86803240 @default.
• W3199482607 hasConceptScore W3199482607C126894567 @default.
• W3199482607 hasConceptScore W3199482607C138944611 @default.
• W3199482607 hasConceptScore W3199482607C14086860 @default.
• W3199482607 hasConceptScore W3199482607C159047783 @default.
• W3199482607 hasConceptScore W3199482607C159654299 @default.
• W3199482607 hasConceptScore W3199482607C203014093 @default.
• W3199482607 hasConceptScore W3199482607C2522874641 @default.
• W3199482607 hasConceptScore W3199482607C2776408679 @default.
• W3199482607 hasConceptScore W3199482607C2776507628 @default.
• W3199482607 hasConceptScore W3199482607C2779261636 @default.
• W3199482607 hasConceptScore W3199482607C542903549 @default.
• W3199482607 hasConceptScore W3199482607C71924100 @default.
• W3199482607 hasConceptScore W3199482607C86803240 @default.
• W3199482607 hasLocation W31994826071 @default.
• W3199482607 hasOpenAccess W3199482607 @default.
• W3199482607 hasPrimaryLocation W31994826071 @default.
• W3199482607 hasRelatedWork W12225117 @default.
• W3199482607 hasRelatedWork W12415232 @default.
• W3199482607 hasRelatedWork W13120329 @default.
• W3199482607 hasRelatedWork W13771988 @default.
• W3199482607 hasRelatedWork W1968801 @default.
• W3199482607 hasRelatedWork W21660817 @default.
• W3199482607 hasRelatedWork W28810456 @default.
• W3199482607 hasRelatedWork W29939032 @default.

• next