FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199490494> ?p ?o ?g. }

• W3199490494 abstract "Our world is filled with microbes. Each multicellular organism has developed ways to interact with this microbial environment. Microbes do not always pose a threat; they can contribute to many processes that benefit the host. Upon colonization both host and microbes adapt resulting in dynamic ecosystems in different host niches. Regulatory processes develop within the host to prevent overt inflammation to beneficial microbes, yet keeping the possibility to respond when pathogens attempt to adhere and invade tissues. This review will focus on microbial colonization and the early (innate) host immune response, with special emphasis on the microbiota-modifying roles of IL-10 and IL-22 in the intestine. IL-10 knock out mice show an altered microbial composition, and spontaneously develop enterocolitis over time. IL-22 knock out mice, although not developing enterocolitis spontaneously, also have an altered microbial composition and increase of epithelial-adherent bacteria, mainly caused by a decrease in mucin and anti-microbial peptide production. Recently interesting links have been found between the IL-10 and IL-22 pathways. While IL-22 can function as a regulatory cytokine at the mucosal surface, it also has inflammatory roles depending on the context. For example, lack of IL-22 in the IL-10–/– mice model prevents spontaneous colitis development. Additionally, the reduced microbial diversity observed in IL-10–/– mice was also reversed in IL-10/IL-22 double mutant mice ( Gunasekera et al., 2020 ). Since in early life, host immunity develops in parallel and in interaction with colonizing microbes, there is a need for future studies that focus on the effect of the timing of colonization in relation to the developmental phase of the host. To illustrate this, examples from zebrafish research will be compared with studies performed in mammals. Since zebrafish develop from eggs and are directly exposed to the outside microbial world, timing of the development of host immunity and subsequent control of microbial composition, is different from mammals that develop in utero and only get exposed after birth. Likewise, colonization studies using adult germfree mice might yield different results from those using neonatal germfree mice. Lastly, special emphasis will be given to the need for host genotype and environmental (co-housing) control of experiments." @default.
• W3199490494 created "2021-09-27" @default.
• W3199490494 creator A5036460064 @default.
• W3199490494 creator A5080388447 @default.
• W3199490494 creator A5091414134 @default.
• W3199490494 date "2021-09-17" @default.
• W3199490494 modified "2023-10-13" @default.
• W3199490494 title "Colonizing Microbes, IL-10 and IL-22: Keeping the Peace at the Mucosal Surface" @default.
• W3199490494 cites W1130588615 @default.
• W3199490494 cites W1489080036 @default.
• W3199490494 cites W1507781793 @default.
• W3199490494 cites W1716352502 @default.
• W3199490494 cites W1900903488 @default.
• W3199490494 cites W1916213760 @default.
• W3199490494 cites W1922836559 @default.
• W3199490494 cites W1933219276 @default.
• W3199490494 cites W1938903801 @default.
• W3199490494 cites W1963932824 @default.
• W3199490494 cites W1964982794 @default.
• W3199490494 cites W1965910921 @default.
• W3199490494 cites W1967753870 @default.
• W3199490494 cites W1968164741 @default.
• W3199490494 cites W1969012958 @default.
• W3199490494 cites W1972073034 @default.
• W3199490494 cites W1978342924 @default.
• W3199490494 cites W1978634585 @default.
• W3199490494 cites W1979984856 @default.
• W3199490494 cites W1981708015 @default.
• W3199490494 cites W1982229304 @default.
• W3199490494 cites W1984351748 @default.
• W3199490494 cites W1986196795 @default.
• W3199490494 cites W1987389251 @default.
• W3199490494 cites W1997774819 @default.
• W3199490494 cites W1997827675 @default.
• W3199490494 cites W1999615949 @default.
• W3199490494 cites W1999795586 @default.
• W3199490494 cites W1999881028 @default.
• W3199490494 cites W2002987322 @default.
• W3199490494 cites W2005359518 @default.
• W3199490494 cites W2006338438 @default.
• W3199490494 cites W2006711580 @default.
• W3199490494 cites W2007121925 @default.
• W3199490494 cites W2007136776 @default.
• W3199490494 cites W2008758799 @default.
• W3199490494 cites W2011391670 @default.
• W3199490494 cites W2011411661 @default.
• W3199490494 cites W2011696576 @default.
• W3199490494 cites W2013899807 @default.
• W3199490494 cites W2016791801 @default.
• W3199490494 cites W2019645605 @default.
• W3199490494 cites W2031466112 @default.
• W3199490494 cites W2032050124 @default.
• W3199490494 cites W2034560261 @default.
• W3199490494 cites W2036500213 @default.
• W3199490494 cites W2040120039 @default.
• W3199490494 cites W2040601022 @default.
• W3199490494 cites W2043897018 @default.
• W3199490494 cites W2048630989 @default.
• W3199490494 cites W2050016905 @default.
• W3199490494 cites W2056381830 @default.
• W3199490494 cites W2059364985 @default.
• W3199490494 cites W2060144673 @default.
• W3199490494 cites W2060531245 @default.
• W3199490494 cites W2060872094 @default.
• W3199490494 cites W2061881258 @default.
• W3199490494 cites W2068234766 @default.
• W3199490494 cites W2069235136 @default.
• W3199490494 cites W2083466222 @default.
• W3199490494 cites W2083750629 @default.
• W3199490494 cites W2084119784 @default.
• W3199490494 cites W2088533694 @default.
• W3199490494 cites W2089643849 @default.
• W3199490494 cites W2091845172 @default.
• W3199490494 cites W2094129900 @default.
• W3199490494 cites W2096205027 @default.
• W3199490494 cites W2097904070 @default.
• W3199490494 cites W2099977209 @default.
• W3199490494 cites W2100176567 @default.
• W3199490494 cites W2100869640 @default.
• W3199490494 cites W2100971409 @default.
• W3199490494 cites W2102428124 @default.
• W3199490494 cites W2103561589 @default.
• W3199490494 cites W2106684817 @default.
• W3199490494 cites W2107066107 @default.
• W3199490494 cites W2107369528 @default.
• W3199490494 cites W2108155566 @default.
• W3199490494 cites W2109756914 @default.
• W3199490494 cites W2116432220 @default.
• W3199490494 cites W2116802952 @default.
• W3199490494 cites W2125349610 @default.
• W3199490494 cites W2126131092 @default.
• W3199490494 cites W2127533496 @default.
• W3199490494 cites W2127826178 @default.
• W3199490494 cites W2139008734 @default.
• W3199490494 cites W2143364414 @default.
• W3199490494 cites W2145066945 @default.
• W3199490494 cites W2145382951 @default.
• W3199490494 cites W2146074997 @default.
• W3199490494 cites W2150781849 @default.
• W3199490494 cites W2155395286 @default.

• next