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- W3199490655 abstract "Abstract The genetics of cancer progression is important for devising optimal therapeutic strategies. Lysyl oxidase (LOX) is a cancer progression gene that has been studied enough to warrant synthesis of its primary data from association studies. However, reported associations between the LOX G473A (rs1800449) gene polymorphisms and cancer have been inconsistent prompting a meta-analysis so that we could obtain more precise estimates. Databases searches of the published literature yielded seven case-control studies. We calculated pooled odds ratios (ORs) and 95% confidence intervals (CIs) using four genetic models, homozygous (H), recessive (R), dominant (D) and codominant (C). Subgroup analysis was based on ethnicity and cancer type. Outlier analysis was used to examine sources of heterogeneity. Strength of evidence was based on high associative significance (expressed in terms of the Bayes Factor), consistency and magnitude of effects, homogeneity and robustness. H/R outcomes exerted more associative effects than D/C results. Two reasons for these are: (i) H/R analyses precluded outlier treatment; (ii) magnitude of H/R (ORs of > 2.0) was twice that of D/C (ORs > 1.0). All else being equal, significant pooled ORs in all genetic models had high significance (Pa < 10-5). Strong evidence for associations were found in the outcomes for Asian and digestive cancers. In summary, the LOX rs1800449 polymorphism confers significant overall susceptibility, particularly in digestive cancers and places Asians at risk." @default.
- W3199490655 created "2021-09-27" @default.
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- W3199490655 date "2019-12-06" @default.
- W3199490655 modified "2023-09-25" @default.
- W3199490655 title "Lysyl oxidase 473G/A (rs1800449) polymorphism influences the risk of cancer progression: a meta-analysis" @default.
- W3199490655 doi "https://doi.org/10.21203/rs.2.18129/v1" @default.
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