FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199492015> ?p ?o ?g. }

• W3199492015 endingPage "785" @default.
• W3199492015 startingPage "775" @default.
• W3199492015 abstract "In this study, we investigated the activation of TRPV1 and TRPA1 by N-acyl homoserine lactones, quorum sensing molecules produced by Gram-negative bacteria, and the inhibitory effect of TRPV1 and TRPA1 by autoinducing peptides (AIPs), quorum sensing molecules produced by Gram-positive bacteria, using human embryonic kidney 293T cell lines stably expressing human TRPV1 and TRPA1, respectively. As a result, we found that some N-acyl homoserine lactones, such as N-octanoyl-L-homoserine lactone (C8-HSL), N-nonanoyl-L-homoserine lactone (C9-HSL) and N-decanoyl-L-homoserine lactone (C10-HSL), activated both TRPV1 and TRPA1. In addition, we clarified that some N-acyl homoserine lactones, such as N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12-HSL), only activated TRPV1 and N-acyl homoserine lactones having saturated short acyl chain, such as N-acetyl-L-homoserine lactone (C2-HSL) and N-butyryl-L-homoserine lactone (C4-HSL), only activated TRPA1. Furthermore, we found that an AIP, simple linear peptide CHWPR, inhibited both TRPV1 and TRPA1 and peptide having thiolactone ring DICNAYF, the thiolactone ring were formed between C3 to F7, strongly inhibited only the TRPV1. Although the specificity of TRPV1 and TRPA1 for quorum sensing molecules was different, these data suggest that both TRPV1 and TRPA1 would function as receptors for quorum sensing molecule produced by bacteria. Graphical Abstract." @default.
• W3199492015 created "2021-09-27" @default.
• W3199492015 creator A5005930113 @default.
• W3199492015 creator A5056178993 @default.
• W3199492015 creator A5076588462 @default.
• W3199492015 creator A5081535885 @default.
• W3199492015 date "2021-09-23" @default.
• W3199492015 modified "2023-10-14" @default.
• W3199492015 title "Human TRPV1 and TRPA1 are receptors for bacterial quorum sensing molecules" @default.
• W3199492015 cites W1511198581 @default.
• W3199492015 cites W1567514429 @default.
• W3199492015 cites W1598738229 @default.
• W3199492015 cites W1967623483 @default.
• W3199492015 cites W1981577795 @default.
• W3199492015 cites W1982211525 @default.
• W3199492015 cites W2002498499 @default.
• W3199492015 cites W2009967312 @default.
• W3199492015 cites W2010795846 @default.
• W3199492015 cites W2029079310 @default.
• W3199492015 cites W2030074619 @default.
• W3199492015 cites W2031368804 @default.
• W3199492015 cites W2033576768 @default.
• W3199492015 cites W2034217039 @default.
• W3199492015 cites W2034327944 @default.
• W3199492015 cites W2035495492 @default.
• W3199492015 cites W2038275562 @default.
• W3199492015 cites W2064756127 @default.
• W3199492015 cites W2077147982 @default.
• W3199492015 cites W2080357982 @default.
• W3199492015 cites W2084016726 @default.
• W3199492015 cites W2090042528 @default.
• W3199492015 cites W2103447688 @default.
• W3199492015 cites W2106493932 @default.
• W3199492015 cites W2107858407 @default.
• W3199492015 cites W2113061812 @default.
• W3199492015 cites W2116534834 @default.
• W3199492015 cites W2120229762 @default.
• W3199492015 cites W2125448515 @default.
• W3199492015 cites W2130417288 @default.
• W3199492015 cites W2141701343 @default.
• W3199492015 cites W2145299726 @default.
• W3199492015 cites W2148852765 @default.
• W3199492015 cites W2157174760 @default.
• W3199492015 cites W2158052795 @default.
• W3199492015 cites W2189628995 @default.
• W3199492015 cites W2541941721 @default.
• W3199492015 cites W2564462540 @default.
• W3199492015 cites W2607287108 @default.
• W3199492015 cites W2766814657 @default.
• W3199492015 cites W2789809278 @default.
• W3199492015 cites W2799568057 @default.
• W3199492015 cites W2803969691 @default.
• W3199492015 cites W2886345990 @default.
• W3199492015 cites W2890924349 @default.
• W3199492015 cites W2943227439 @default.
• W3199492015 cites W2996221411 @default.
• W3199492015 cites W3082806268 @default.
• W3199492015 cites W3107667798 @default.
• W3199492015 cites W93189466 @default.
• W3199492015 doi "https://doi.org/10.1093/jb/mvab099" @default.
• W3199492015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34557892" @default.
• W3199492015 hasPublicationYear "2021" @default.
• W3199492015 type Work @default.
• W3199492015 sameAs 3199492015 @default.
• W3199492015 citedByCount "4" @default.
• W3199492015 countsByYear W31994920152022 @default.
• W3199492015 countsByYear W31994920152023 @default.
• W3199492015 crossrefType "journal-article" @default.
• W3199492015 hasAuthorship W3199492015A5005930113 @default.
• W3199492015 hasAuthorship W3199492015A5056178993 @default.
• W3199492015 hasAuthorship W3199492015A5076588462 @default.
• W3199492015 hasAuthorship W3199492015A5081535885 @default.
• W3199492015 hasConcept C104317684 @default.
• W3199492015 hasConcept C118687296 @default.
• W3199492015 hasConcept C155164980 @default.
• W3199492015 hasConcept C160145004 @default.
• W3199492015 hasConcept C170493617 @default.
• W3199492015 hasConcept C185592680 @default.
• W3199492015 hasConcept C2776612806 @default.
• W3199492015 hasConcept C2779840497 @default.
• W3199492015 hasConcept C523546767 @default.
• W3199492015 hasConcept C54355233 @default.
• W3199492015 hasConcept C55493867 @default.
• W3199492015 hasConcept C60987743 @default.
• W3199492015 hasConcept C71240020 @default.
• W3199492015 hasConcept C86803240 @default.
• W3199492015 hasConceptScore W3199492015C104317684 @default.
• W3199492015 hasConceptScore W3199492015C118687296 @default.
• W3199492015 hasConceptScore W3199492015C155164980 @default.
• W3199492015 hasConceptScore W3199492015C160145004 @default.
• W3199492015 hasConceptScore W3199492015C170493617 @default.
• W3199492015 hasConceptScore W3199492015C185592680 @default.
• W3199492015 hasConceptScore W3199492015C2776612806 @default.
• W3199492015 hasConceptScore W3199492015C2779840497 @default.
• W3199492015 hasConceptScore W3199492015C523546767 @default.
• W3199492015 hasConceptScore W3199492015C54355233 @default.
• W3199492015 hasConceptScore W3199492015C55493867 @default.
• W3199492015 hasConceptScore W3199492015C60987743 @default.

• next