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- W3199492685 abstract "A Fluorescence In-Situ Hybridization (FISH) based translocation dose-response curve has been constructed for biodosimetry application in our nuclear establishment at Kalpakkam, India. Peripheral blood sample from a healthy male donor (27 years) was exposed to nine different doses (0.1 Gy–5 Gy) of 137Cs γ-rays (100 mGy/min) in an automated calibration facility with a linear distancing system and subjected to FISH assay using chromosome 1, 2 and 4 specific fluorescent probes. Validation of the dose-response curve was done following three different approaches i) by blind test method ii) using blood samples exposed to γ doses (0.5, 1 & 2 Gy) at different dose rates (124, 23 & 10 mGy/min) and iii) with blood samples exposed to 0.5, 1 & 2 Gy γ doses at changing dose rates (increasing and decreasing dose rates). Results showed that a predefined dose-response curve constructed at a particular acute dose rate can be used for dose estimation in exposures involving varying dose rates and changing dose rate scenarios." @default.
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- W3199492685 date "2021-10-01" @default.
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- W3199492685 title "Translocation dose-response curve for 137Cs γ-rays: Dose validation at various dose rate and changing dose rate conditions" @default.
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- W3199492685 doi "https://doi.org/10.1016/j.mrgentox.2021.503406" @default.
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