Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199501531> ?p ?o ?g. }
- W3199501531 endingPage "3952" @default.
- W3199501531 startingPage "3937" @default.
- W3199501531 abstract "Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis.Films were synthesized by double solvent casting technique having an antibiotic in the gellan gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary layer.Prepared films were transparent, flexible, and showed high antibacterial response against both gram-positive and gram-negative bacteria. The films showed excellent pharmaceutical attributes in terms of drug content, folding endurance, swelling index, and mucoadhesive strength. Solid state characterization of formulation showed successful incorporation of drug and oil in separate layers of hydrogel structure. An in-vitro release study showed an initial burst release of drug followed by sustained release for up to 48 hours.The prepared mucoadhesive bilayer buccal films could be used as a potential therapeutic option for the management of periodontitis." @default.
- W3199501531 created "2021-09-27" @default.
- W3199501531 creator A5000944195 @default.
- W3199501531 creator A5008284776 @default.
- W3199501531 creator A5061610498 @default.
- W3199501531 creator A5067106976 @default.
- W3199501531 creator A5067967977 @default.
- W3199501531 date "2021-09-01" @default.
- W3199501531 modified "2023-10-13" @default.
- W3199501531 title "Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis" @default.
- W3199501531 cites W1788547428 @default.
- W3199501531 cites W1924133370 @default.
- W3199501531 cites W1971219227 @default.
- W3199501531 cites W1972517758 @default.
- W3199501531 cites W1985760648 @default.
- W3199501531 cites W1991087780 @default.
- W3199501531 cites W1996187271 @default.
- W3199501531 cites W2007433487 @default.
- W3199501531 cites W2012262104 @default.
- W3199501531 cites W2013329897 @default.
- W3199501531 cites W2017533816 @default.
- W3199501531 cites W2025763283 @default.
- W3199501531 cites W2029738042 @default.
- W3199501531 cites W2031210225 @default.
- W3199501531 cites W2037471099 @default.
- W3199501531 cites W2047286887 @default.
- W3199501531 cites W2052634646 @default.
- W3199501531 cites W2053778212 @default.
- W3199501531 cites W2055393668 @default.
- W3199501531 cites W2074370512 @default.
- W3199501531 cites W2077000892 @default.
- W3199501531 cites W2083669433 @default.
- W3199501531 cites W2102133814 @default.
- W3199501531 cites W2108064520 @default.
- W3199501531 cites W2119036220 @default.
- W3199501531 cites W2123764876 @default.
- W3199501531 cites W2123939336 @default.
- W3199501531 cites W2136163937 @default.
- W3199501531 cites W2147660958 @default.
- W3199501531 cites W2148619779 @default.
- W3199501531 cites W2148620725 @default.
- W3199501531 cites W2185564569 @default.
- W3199501531 cites W2229629572 @default.
- W3199501531 cites W2347191124 @default.
- W3199501531 cites W2419293159 @default.
- W3199501531 cites W2749068957 @default.
- W3199501531 cites W2749183196 @default.
- W3199501531 cites W2791639731 @default.
- W3199501531 cites W2793040573 @default.
- W3199501531 cites W2808035335 @default.
- W3199501531 cites W2811039974 @default.
- W3199501531 cites W2855412943 @default.
- W3199501531 cites W2884881227 @default.
- W3199501531 cites W2897903986 @default.
- W3199501531 cites W2905420437 @default.
- W3199501531 cites W2910424966 @default.
- W3199501531 cites W2990060381 @default.
- W3199501531 cites W2990641422 @default.
- W3199501531 cites W3003754906 @default.
- W3199501531 cites W3016055222 @default.
- W3199501531 cites W3025433206 @default.
- W3199501531 cites W3041908825 @default.
- W3199501531 cites W3097754436 @default.
- W3199501531 cites W3138837226 @default.
- W3199501531 cites W3157929082 @default.
- W3199501531 cites W3158740779 @default.
- W3199501531 cites W3176526861 @default.
- W3199501531 cites W3190250292 @default.
- W3199501531 cites W44078951 @default.
- W3199501531 doi "https://doi.org/10.2147/dddt.s328722" @default.
- W3199501531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8453438" @default.
- W3199501531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34556975" @default.
- W3199501531 hasPublicationYear "2021" @default.
- W3199501531 type Work @default.
- W3199501531 sameAs 3199501531 @default.
- W3199501531 citedByCount "13" @default.
- W3199501531 countsByYear W31995015312022 @default.
- W3199501531 countsByYear W31995015312023 @default.
- W3199501531 crossrefType "journal-article" @default.
- W3199501531 hasAuthorship W3199501531A5000944195 @default.
- W3199501531 hasAuthorship W3199501531A5008284776 @default.
- W3199501531 hasAuthorship W3199501531A5061610498 @default.
- W3199501531 hasAuthorship W3199501531A5067106976 @default.
- W3199501531 hasAuthorship W3199501531A5067967977 @default.
- W3199501531 hasBestOaLocation W31995015311 @default.
- W3199501531 hasConcept C159985019 @default.
- W3199501531 hasConcept C185592680 @default.
- W3199501531 hasConcept C192157962 @default.
- W3199501531 hasConcept C192562407 @default.
- W3199501531 hasConcept C195735259 @default.
- W3199501531 hasConcept C199343813 @default.
- W3199501531 hasConcept C2776035855 @default.
- W3199501531 hasConcept C2777937549 @default.
- W3199501531 hasConcept C2778512257 @default.
- W3199501531 hasConcept C2778540859 @default.
- W3199501531 hasConcept C2778714489 @default.
- W3199501531 hasConcept C2780183776 @default.
- W3199501531 hasConcept C2780385504 @default.