FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199520539> ?p ?o ?g. }

• W3199520539 abstract "Skeletal muscle contractile proteins require a constant supply of energy to produce force needed for movement. Energy (ATP) is primarily produced by mitochondrial organelles, located within and around muscle fibers, by oxidative phosphorylation that couples electron flux through the electron transport chain to create a proton gradient across the inner mitochondrial membrane that is in turn used by the ATP synthase. Mitochondrial networks increase in size by biogenesis to increase mitochondrial abundance and activity in response to endurance exercise, while their function and content reduce with constant inactivity, such as during muscle atrophy. During healthy aging, there is an overall decline in mitochondrial activity and abundance, increase in mitochondrial DNA mutations, potential increase in oxidative stress, and reduction in overall muscular capacity. Many of these alterations can be attenuated by consistent endurance exercise. Children with cerebral palsy (CP) have significantly increased energetics of movement, reduced endurance capacity, and increased perceived effort. Recent work in leg muscles in ambulatory children with CP show a marked reduction in mitochondrial function. Arm muscles show that mitochondrial protein content and mitochondria DNA copy number are lower, suggesting a reduction in mitochondrial abundance, along with a reduction in markers for mitochondrial biogenesis. Gene expression networks are reduced for glycolytic and mitochondrial pathways and share similarities with gene networks with aging and chronic inactivity. Given the importance of mitochondria for energy production and changes with aging, future work needs to assess changes in mitochondria across the lifespan in people with CP and the effect of exercise on promoting metabolic health." @default.
• W3199520539 created "2021-09-27" @default.
• W3199520539 creator A5051104516 @default.
• W3199520539 date "2021-09-13" @default.
• W3199520539 modified "2023-09-27" @default.
• W3199520539 title "Skeletal Muscle Mitochondrial Physiology in Children With Cerebral Palsy: Considerations for Healthy Aging" @default.
• W3199520539 cites W1493148123 @default.
• W3199520539 cites W1532581741 @default.
• W3199520539 cites W1535651110 @default.
• W3199520539 cites W1597116068 @default.
• W3199520539 cites W1615913434 @default.
• W3199520539 cites W1865433224 @default.
• W3199520539 cites W1913796783 @default.
• W3199520539 cites W1968408636 @default.
• W3199520539 cites W1980869648 @default.
• W3199520539 cites W1982216425 @default.
• W3199520539 cites W1995746292 @default.
• W3199520539 cites W2003301619 @default.
• W3199520539 cites W2020985206 @default.
• W3199520539 cites W2022167001 @default.
• W3199520539 cites W2031959105 @default.
• W3199520539 cites W2033515464 @default.
• W3199520539 cites W2040798277 @default.
• W3199520539 cites W2051476652 @default.
• W3199520539 cites W2051691468 @default.
• W3199520539 cites W2053987441 @default.
• W3199520539 cites W2071615263 @default.
• W3199520539 cites W2087969944 @default.
• W3199520539 cites W2093251867 @default.
• W3199520539 cites W2101117598 @default.
• W3199520539 cites W2106345877 @default.
• W3199520539 cites W2107621770 @default.
• W3199520539 cites W2116817481 @default.
• W3199520539 cites W2117658071 @default.
• W3199520539 cites W2121776678 @default.
• W3199520539 cites W2122341467 @default.
• W3199520539 cites W2123564531 @default.
• W3199520539 cites W2125143938 @default.
• W3199520539 cites W2126939025 @default.
• W3199520539 cites W2130025116 @default.
• W3199520539 cites W2134036439 @default.
• W3199520539 cites W2142483199 @default.
• W3199520539 cites W2143588920 @default.
• W3199520539 cites W2150503470 @default.
• W3199520539 cites W2166174426 @default.
• W3199520539 cites W2166664098 @default.
• W3199520539 cites W2166740727 @default.
• W3199520539 cites W2168357572 @default.
• W3199520539 cites W2181706964 @default.
• W3199520539 cites W2255055869 @default.
• W3199520539 cites W2398790608 @default.
• W3199520539 cites W2481350377 @default.
• W3199520539 cites W2507012638 @default.
• W3199520539 cites W2517338531 @default.
• W3199520539 cites W2586648405 @default.
• W3199520539 cites W2726026230 @default.
• W3199520539 cites W2789764368 @default.
• W3199520539 cites W2802160823 @default.
• W3199520539 cites W2900974539 @default.
• W3199520539 cites W2907492818 @default.
• W3199520539 cites W2913264965 @default.
• W3199520539 cites W2944730596 @default.
• W3199520539 cites W2945027082 @default.
• W3199520539 cites W2997046468 @default.
• W3199520539 cites W3017214959 @default.
• W3199520539 cites W3120226284 @default.
• W3199520539 cites W3176808958 @default.
• W3199520539 cites W4205442673 @default.
• W3199520539 cites W4206062136 @default.
• W3199520539 cites W4235108552 @default.
• W3199520539 cites W4241136696 @default.
• W3199520539 cites W4243543929 @default.
• W3199520539 cites W4243889566 @default.
• W3199520539 doi "https://doi.org/10.3389/fneur.2021.735009" @default.
• W3199520539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8473886" @default.
• W3199520539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34589051" @default.
• W3199520539 hasPublicationYear "2021" @default.
• W3199520539 type Work @default.
• W3199520539 sameAs 3199520539 @default.
• W3199520539 citedByCount "0" @default.
• W3199520539 crossrefType "journal-article" @default.
• W3199520539 hasAuthorship W3199520539A5051104516 @default.
• W3199520539 hasBestOaLocation W31995205391 @default.
• W3199520539 hasConcept C104317684 @default.
• W3199520539 hasConcept C112243037 @default.
• W3199520539 hasConcept C126322002 @default.
• W3199520539 hasConcept C134018914 @default.
• W3199520539 hasConcept C24586158 @default.
• W3199520539 hasConcept C2776151105 @default.
• W3199520539 hasConcept C2777229759 @default.
• W3199520539 hasConcept C2779959927 @default.
• W3199520539 hasConcept C28859421 @default.
• W3199520539 hasConcept C55493867 @default.
• W3199520539 hasConcept C57600042 @default.
• W3199520539 hasConcept C71924100 @default.
• W3199520539 hasConcept C86803240 @default.
• W3199520539 hasConcept C95444343 @default.
• W3199520539 hasConcept C99830354 @default.
• W3199520539 hasConceptScore W3199520539C104317684 @default.
• W3199520539 hasConceptScore W3199520539C112243037 @default.

• next