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- W3199523617 abstract "In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated. Here, we investigated the capacity of primary and immortalized fibroblasts of distinct origins to degrade a gelatin/alginate/fibrin (GAF)-based biomaterial. We further established that fibrin was targeted by degradative fibroblasts through the secretion of fibrinolytic matrix-metalloproteinases (MMPs) and urokinase, two types of serine protease. Finally, we demonstrated that besides aprotinin, specific targeting of fibrinolytic MMPs and urokinase led to cell-laden GAF stability for at least several days. These results support the use of specific strategies to tune fibrin-based biomaterials degradation over time. It emphasizes the need to choose the right cell type and further bring targeted solutions to avoid the degradation of fibrin-containing hydrogels or bioinks." @default.
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- W3199523617 date "2021-09-23" @default.
- W3199523617 modified "2023-09-30" @default.
- W3199523617 title "Controlling fibroblast fibrinolytic activity allows for the bio-engineering of stable connective tissue equivalents" @default.
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- W3199523617 doi "https://doi.org/10.1101/2021.09.21.461032" @default.
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