FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199545669> ?p ?o ?g. }

• W3199545669 endingPage "1714" @default.
• W3199545669 startingPage "1699" @default.
• W3199545669 abstract "Multiple myeloma presents with numerous primary genomic lesions that broadly dichotomize cases into hyperdiploidy or IgH translocated. Clinically, these large alterations are assessed by fluorescence in situ hybridization (FISH) for risk stratification at diagnosis. Secondary focal events, including indels and single-nucleotide variants, are also reported; however, their clinical correlates are poorly described, and FISH has insufficient resolution to assess many of them. This study examined the exonic sequences of 26 genes reported to be mutated in >1% of patients with myeloma using a custom panel. These exons were sequenced to approximately 1000 times in a cohort of 76 patients from Atlantic Canada with detailed clinical correlates and in four multiple myeloma cell lines. Across the 76 patients, 255 mutations and 33 focal copy number variations were identified. High-severity mutations and mutations predicted by FATHMM-XF to be pathogenic identified patients with significantly reduced progression-free survival. These mutations were mutually exclusive from the Revised International Staging System high-risk FISH markers and were independent of all biochemical parameters of the Revised International Staging System. Applying our panel to patients classified by FISH to be standard risk successfully reclassified patients into high- and standard-risk groups. Furthermore, three patients in our cohort each had two high-risk markers; two of these patients developed plasma cell leukemia, a rare and severe clinical sequela of multiple myeloma." @default.
• W3199545669 created "2021-09-27" @default.
• W3199545669 creator A5002970103 @default.
• W3199545669 creator A5004261817 @default.
• W3199545669 creator A5006781525 @default.
• W3199545669 creator A5016415380 @default.
• W3199545669 creator A5018685925 @default.
• W3199545669 creator A5041398877 @default.
• W3199545669 creator A5047298863 @default.
• W3199545669 creator A5049410107 @default.
• W3199545669 creator A5066588179 @default.
• W3199545669 creator A5081585044 @default.
• W3199545669 creator A5083200981 @default.
• W3199545669 creator A5084816699 @default.
• W3199545669 creator A5088189511 @default.
• W3199545669 creator A5091091951 @default.
• W3199545669 date "2021-12-01" @default.
• W3199545669 modified "2023-09-28" @default.
• W3199545669 title "DMG26" @default.
• W3199545669 cites W1842472614 @default.
• W3199545669 cites W1966876766 @default.
• W3199545669 cites W2020234719 @default.
• W3199545669 cites W2028330103 @default.
• W3199545669 cites W2038477042 @default.
• W3199545669 cites W2041236924 @default.
• W3199545669 cites W2059581635 @default.
• W3199545669 cites W2060965924 @default.
• W3199545669 cites W2075032656 @default.
• W3199545669 cites W2076357933 @default.
• W3199545669 cites W2101035019 @default.
• W3199545669 cites W2104195581 @default.
• W3199545669 cites W2106578986 @default.
• W3199545669 cites W2108234281 @default.
• W3199545669 cites W2108495564 @default.
• W3199545669 cites W2124535406 @default.
• W3199545669 cites W2128192762 @default.
• W3199545669 cites W2132838873 @default.
• W3199545669 cites W2136810538 @default.
• W3199545669 cites W2137886330 @default.
• W3199545669 cites W2138601221 @default.
• W3199545669 cites W2150997370 @default.
• W3199545669 cites W2154397429 @default.
• W3199545669 cites W2154819492 @default.
• W3199545669 cites W2158833600 @default.
• W3199545669 cites W2161609653 @default.
• W3199545669 cites W2169846247 @default.
• W3199545669 cites W2170515647 @default.
• W3199545669 cites W2214159341 @default.
• W3199545669 cites W2225726427 @default.
• W3199545669 cites W2273717782 @default.
• W3199545669 cites W2323851578 @default.
• W3199545669 cites W2494443970 @default.
• W3199545669 cites W2511571730 @default.
• W3199545669 cites W2512608293 @default.
• W3199545669 cites W2591058932 @default.
• W3199545669 cites W2612968490 @default.
• W3199545669 cites W2618857260 @default.
• W3199545669 cites W2739371285 @default.
• W3199545669 cites W2748437956 @default.
• W3199545669 cites W2751686252 @default.
• W3199545669 cites W2754485588 @default.
• W3199545669 cites W2766494630 @default.
• W3199545669 cites W2770026599 @default.
• W3199545669 cites W2799281677 @default.
• W3199545669 cites W2805293188 @default.
• W3199545669 cites W2809698015 @default.
• W3199545669 cites W2810575454 @default.
• W3199545669 cites W2885104676 @default.
• W3199545669 cites W2887448109 @default.
• W3199545669 cites W2898789672 @default.
• W3199545669 cites W2902732853 @default.
• W3199545669 cites W2906937763 @default.
• W3199545669 cites W2909137860 @default.
• W3199545669 cites W2909194804 @default.
• W3199545669 cites W2920581956 @default.
• W3199545669 cites W2937502263 @default.
• W3199545669 cites W2944536895 @default.
• W3199545669 cites W2950987362 @default.
• W3199545669 cites W2991321296 @default.
• W3199545669 cites W2996700807 @default.
• W3199545669 cites W3005768323 @default.
• W3199545669 cites W3084860467 @default.
• W3199545669 cites W3088870507 @default.
• W3199545669 cites W4211058750 @default.
• W3199545669 doi "https://doi.org/10.1016/j.jmoldx.2021.08.011" @default.
• W3199545669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34562616" @default.
• W3199545669 hasPublicationYear "2021" @default.
• W3199545669 type Work @default.
• W3199545669 sameAs 3199545669 @default.
• W3199545669 citedByCount "0" @default.
• W3199545669 crossrefType "journal-article" @default.
• W3199545669 hasAuthorship W3199545669A5002970103 @default.
• W3199545669 hasAuthorship W3199545669A5004261817 @default.
• W3199545669 hasAuthorship W3199545669A5006781525 @default.
• W3199545669 hasAuthorship W3199545669A5016415380 @default.
• W3199545669 hasAuthorship W3199545669A5018685925 @default.
• W3199545669 hasAuthorship W3199545669A5041398877 @default.
• W3199545669 hasAuthorship W3199545669A5047298863 @default.

• next