FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199563338> ?p ?o ?g. }

• W3199563338 abstract "Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection confers protection against a broad-spectrum of lethal bacterial infections. Whether this protection persists over time is unknown. To tackle this question, we analyzed the immune status and the response to Listeria monocytogenes (L. monocytogenes) of mice trained 9 weeks before analysis. The induction of trained immunity increased bone marrow myelopoiesis and blood counts of Ly6Chigh inflammatory monocytes and polymorphonuclear neutrophils (PMNs). Ex vivo, whole blood, PMNs and monocytes from trained mice produced increased levels of cytokines in response to microbial products and limited the growth of L. monocytogenes. In vivo, following challenge with L. monocytogenes, peripheral blood leukocytes were massively depleted in control mice but largely preserved in trained mice. PMNs were reduced also in the spleen from control mice, and increased in the spleen of trained mice. In transwell experiments, PMNs from trained mice showed increased spontaneous migration and CXCL2/MIP2α-induced chemotaxis, suggesting that training promotes the migration of PMNs in peripheral organs targeted by L. monocytogenes. Trained PMNs and monocytes had higher glycolytic activity and mitochondrial respiration than control cells when exposed to L. monocytogenes. Bacterial burden and dissemination in blood, spleen and liver as well as systemic cytokines and inflammation (multiplex bead assay and bioluminescence imaging) were reduced in trained mice. In full agreement with these results, mice trained 9 weeks before infection were powerfully protected from lethal listeriosis. Altogether, these data suggest that training increases the generation and the antimicrobial activity of PMNs and monocytes, which may confer prolonged protection from lethal bacterial infection." @default.
• W3199563338 created "2021-09-27" @default.
• W3199563338 creator A5001379147 @default.
• W3199563338 creator A5034837078 @default.
• W3199563338 creator A5053283797 @default.
• W3199563338 creator A5054601272 @default.
• W3199563338 creator A5056016950 @default.
• W3199563338 creator A5056517031 @default.
• W3199563338 creator A5056658755 @default.
• W3199563338 creator A5058282104 @default.
• W3199563338 creator A5063634938 @default.
• W3199563338 creator A5068633550 @default.
• W3199563338 date "2021-09-17" @default.
• W3199563338 modified "2023-10-12" @default.
• W3199563338 title "Trained Immunity Confers Prolonged Protection From Listeriosis" @default.
• W3199563338 cites W2059403792 @default.
• W3199563338 cites W2065854688 @default.
• W3199563338 cites W2067031028 @default.
• W3199563338 cites W2108040405 @default.
• W3199563338 cites W2116797415 @default.
• W3199563338 cites W2128337342 @default.
• W3199563338 cites W2137149030 @default.
• W3199563338 cites W2140876277 @default.
• W3199563338 cites W2144072179 @default.
• W3199563338 cites W2206617731 @default.
• W3199563338 cites W2266564746 @default.
• W3199563338 cites W2272814930 @default.
• W3199563338 cites W2468936205 @default.
• W3199563338 cites W2471715225 @default.
• W3199563338 cites W2557169014 @default.
• W3199563338 cites W2558691630 @default.
• W3199563338 cites W2560235353 @default.
• W3199563338 cites W2626467057 @default.
• W3199563338 cites W2746117114 @default.
• W3199563338 cites W2763093869 @default.
• W3199563338 cites W2766609999 @default.
• W3199563338 cites W2772137331 @default.
• W3199563338 cites W2782649526 @default.
• W3199563338 cites W2783037826 @default.
• W3199563338 cites W2783329544 @default.
• W3199563338 cites W2783642412 @default.
• W3199563338 cites W2783711120 @default.
• W3199563338 cites W2796983933 @default.
• W3199563338 cites W2804832608 @default.
• W3199563338 cites W2888169023 @default.
• W3199563338 cites W2889763617 @default.
• W3199563338 cites W2895418972 @default.
• W3199563338 cites W2898375074 @default.
• W3199563338 cites W2900601355 @default.
• W3199563338 cites W2916861400 @default.
• W3199563338 cites W2939625028 @default.
• W3199563338 cites W2940394837 @default.
• W3199563338 cites W2952520385 @default.
• W3199563338 cites W2953946606 @default.
• W3199563338 cites W2977879715 @default.
• W3199563338 cites W2987625651 @default.
• W3199563338 cites W2991556906 @default.
• W3199563338 cites W2998293467 @default.
• W3199563338 cites W3006316914 @default.
• W3199563338 cites W3009920944 @default.
• W3199563338 cites W3011396768 @default.
• W3199563338 cites W3023662906 @default.
• W3199563338 cites W3027074285 @default.
• W3199563338 cites W3036112005 @default.
• W3199563338 cites W3038518616 @default.
• W3199563338 cites W3047982948 @default.
• W3199563338 cites W3097197008 @default.
• W3199563338 cites W3100724954 @default.
• W3199563338 cites W3106444534 @default.
• W3199563338 cites W3112419967 @default.
• W3199563338 cites W3144554272 @default.
• W3199563338 cites W3165720855 @default.
• W3199563338 cites W3182846223 @default.
• W3199563338 doi "https://doi.org/10.3389/fimmu.2021.723393" @default.
• W3199563338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8484647" @default.
• W3199563338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34603295" @default.
• W3199563338 hasPublicationYear "2021" @default.
• W3199563338 type Work @default.
• W3199563338 sameAs 3199563338 @default.
• W3199563338 citedByCount "14" @default.
• W3199563338 countsByYear W31995633382022 @default.
• W3199563338 countsByYear W31995633382023 @default.
• W3199563338 crossrefType "journal-article" @default.
• W3199563338 hasAuthorship W3199563338A5001379147 @default.
• W3199563338 hasAuthorship W3199563338A5034837078 @default.
• W3199563338 hasAuthorship W3199563338A5053283797 @default.
• W3199563338 hasAuthorship W3199563338A5054601272 @default.
• W3199563338 hasAuthorship W3199563338A5056016950 @default.
• W3199563338 hasAuthorship W3199563338A5056517031 @default.
• W3199563338 hasAuthorship W3199563338A5056658755 @default.
• W3199563338 hasAuthorship W3199563338A5058282104 @default.
• W3199563338 hasAuthorship W3199563338A5063634938 @default.
• W3199563338 hasAuthorship W3199563338A5068633550 @default.
• W3199563338 hasBestOaLocation W31995633381 @default.
• W3199563338 hasConcept C109159458 @default.
• W3199563338 hasConcept C136449434 @default.
• W3199563338 hasConcept C203014093 @default.
• W3199563338 hasConcept C2779341262 @default.
• W3199563338 hasConcept C2780007613 @default.
• W3199563338 hasConcept C2780931953 @default.

• next