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• W3199564340 abstract "<h3>Introduction</h3> It has been demonstrated that the quantitative Faecal immunochemical test (FIT) could be an accurate method for prioritizing symptomatic patients for the rapid detection of cancer. A quantitative FIT-based strategy performs better compared to the current high-risk symptoms-based strategies in fast tracking the suspected cancer referrals. A score, which combines quantitative FIT, age and sex to estimate the risk of advanced neoplasia (AN) in a symptomatic population, could help a physician in their decision-making process and in the proper allocation of endoscopic resources¹. The aim of this study is to assess the performance of such a score in an independent British symptomatic patient cohort. <h3>Methods</h3> Symptomatic individuals referred for a diagnostic colonoscopy at University Hospital Coventry & Warwickshire were included. Patients were given a FIT HM-JACKarc prior to their colonoscopy. The main outcome was AN. The risk score was assigned, ranging 0–11 points, according to the presence or absence of risk factors: sex (female=0, male= 2 points), age (<40 years = 0, 41–50 years = 1, 51–60 years = 2, 61–70 years = 3, >70 years = 4) and positivity of FIT (< 10 μg Hb/g faeces = 0, ≥ 10 μg Hb/g faeces = 5). 10 μg Hb/g faeces was considered as the positivity threshold for FIT. <h3>Results</h3> 612 individuals were included and 51% (310) of whom were women. The mean age of the study cohort was 68 years. [IQR 57–76]. AN was detected in 9% (55) of the patients. Figure 1 shows the observed probability (dotted line) and expected probability (continuous line) of AN, according to FIT based-risk score. <h3>Conclusion</h3> A risk score, which combines quantitative FIT, age and sex can accurately estimate the risk of having AN in a symptomatic British population. <h3>Reference</h3> Rodríguez-Alonso L, Rodríguez-Moranta F, Ruiz-Cerulla A, <i>et al</i>. An urgent referral strategy for symptomatic patients with suspected colorectal cancer based on a quantitative immunochemical faecal occult blood test. <i>Dig Liver Dis</i> 2015;<b>47</b>(9):797–804. doi:10.1016/j.dld.2015.05.004" @default.
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• W3199564340 date "2021-01-01" @default.
• W3199564340 modified "2023-10-16" @default.
• W3199564340 title "P293 External validation of a faecal immunochemical test based-risk score for advanced neoplasia in symptomatic patients" @default.
• W3199564340 doi "https://doi.org/10.1136/gutjnl-2020-bsgcampus.367" @default.
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