Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199575372> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3199575372 endingPage "109948" @default.
- W3199575372 startingPage "109948" @default.
- W3199575372 abstract "To investigate whether enhancement on MRI could help identify HER2 overexpression in breast cancer brain metastases.We derived a cohort of 38 histologically proven breast cancer brain metastases with preoperative contrast-enhanced brain MRI and HER2 fluorescent in-situ hybridization of the resected/biopsied brain specimens from 2018 to 2021. Enhancement of the lesions was measured and compared using t-tests. Receiver operating characteristic and logistic regression analyses were performed to evaluate the performance of MRI enhancement in identifying HER2 overexpression.The study cohort was comprised of 29 women with a mean age of 55 years (range: 31-81 years) with a total of 38 distinct lesions. The HER2-positive subcohort was comprised of 17 patients, while the HER2-negative subcohort was comprised of 13 patients. The percent signal intensity change (PSIC) of HER2-positive breast cancer brain metastases was significantly greater than that of HER2-negative lesions (310 v. 153, P = 0.002). The PSIC differentiated HER2-positive lesions from HER2-negative lesions with an area under the curve of 0.88 (P < 0.001). In a model controlling for lesion size, lesion location, tumor grade, patient age, scanner magnetic field strength, and contrast agent, the PSIC had an accuracy of 92% (35/38), sensitivity of 96% (23/24), and specificity of 86% (12/14) in differentiating HER2-positive lesions from HER2-negative lesions.Enhancement on MRI may assist in identifying HER2 overexpression in breast cancer brain metastases, if validated prospectively." @default.
- W3199575372 created "2021-09-27" @default.
- W3199575372 creator A5005344580 @default.
- W3199575372 creator A5007678843 @default.
- W3199575372 creator A5028867448 @default.
- W3199575372 creator A5036266050 @default.
- W3199575372 creator A5077198525 @default.
- W3199575372 creator A5090098488 @default.
- W3199575372 date "2021-11-01" @default.
- W3199575372 modified "2023-09-27" @default.
- W3199575372 title "Performance of enhancement on brain MRI for identifying HER2 overexpression in breast cancer brain metastases" @default.
- W3199575372 cites W1497249325 @default.
- W3199575372 cites W2020388387 @default.
- W3199575372 cites W2070264012 @default.
- W3199575372 cites W2172234325 @default.
- W3199575372 cites W2521263872 @default.
- W3199575372 cites W2583004967 @default.
- W3199575372 cites W2616365912 @default.
- W3199575372 cites W2770375880 @default.
- W3199575372 cites W2806074020 @default.
- W3199575372 cites W2810369514 @default.
- W3199575372 cites W2810500162 @default.
- W3199575372 cites W2947783920 @default.
- W3199575372 cites W2972399366 @default.
- W3199575372 cites W2996630100 @default.
- W3199575372 cites W3001297102 @default.
- W3199575372 cites W3030461309 @default.
- W3199575372 cites W3043096450 @default.
- W3199575372 cites W3083176429 @default.
- W3199575372 doi "https://doi.org/10.1016/j.ejrad.2021.109948" @default.
- W3199575372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34534735" @default.
- W3199575372 hasPublicationYear "2021" @default.
- W3199575372 type Work @default.
- W3199575372 sameAs 3199575372 @default.
- W3199575372 citedByCount "5" @default.
- W3199575372 countsByYear W31995753722022 @default.
- W3199575372 countsByYear W31995753722023 @default.
- W3199575372 crossrefType "journal-article" @default.
- W3199575372 hasAuthorship W3199575372A5005344580 @default.
- W3199575372 hasAuthorship W3199575372A5007678843 @default.
- W3199575372 hasAuthorship W3199575372A5028867448 @default.
- W3199575372 hasAuthorship W3199575372A5036266050 @default.
- W3199575372 hasAuthorship W3199575372A5077198525 @default.
- W3199575372 hasAuthorship W3199575372A5090098488 @default.
- W3199575372 hasConcept C121608353 @default.
- W3199575372 hasConcept C126322002 @default.
- W3199575372 hasConcept C126838900 @default.
- W3199575372 hasConcept C142724271 @default.
- W3199575372 hasConcept C143409427 @default.
- W3199575372 hasConcept C143998085 @default.
- W3199575372 hasConcept C2778164965 @default.
- W3199575372 hasConcept C2779013556 @default.
- W3199575372 hasConcept C2781156865 @default.
- W3199575372 hasConcept C530470458 @default.
- W3199575372 hasConcept C58471807 @default.
- W3199575372 hasConcept C71924100 @default.
- W3199575372 hasConceptScore W3199575372C121608353 @default.
- W3199575372 hasConceptScore W3199575372C126322002 @default.
- W3199575372 hasConceptScore W3199575372C126838900 @default.
- W3199575372 hasConceptScore W3199575372C142724271 @default.
- W3199575372 hasConceptScore W3199575372C143409427 @default.
- W3199575372 hasConceptScore W3199575372C143998085 @default.
- W3199575372 hasConceptScore W3199575372C2778164965 @default.
- W3199575372 hasConceptScore W3199575372C2779013556 @default.
- W3199575372 hasConceptScore W3199575372C2781156865 @default.
- W3199575372 hasConceptScore W3199575372C530470458 @default.
- W3199575372 hasConceptScore W3199575372C58471807 @default.
- W3199575372 hasConceptScore W3199575372C71924100 @default.
- W3199575372 hasLocation W31995753721 @default.
- W3199575372 hasLocation W31995753722 @default.
- W3199575372 hasOpenAccess W3199575372 @default.
- W3199575372 hasPrimaryLocation W31995753721 @default.
- W3199575372 hasRelatedWork W1967894062 @default.
- W3199575372 hasRelatedWork W2355892046 @default.
- W3199575372 hasRelatedWork W2400727047 @default.
- W3199575372 hasRelatedWork W2569361952 @default.
- W3199575372 hasRelatedWork W3208457147 @default.
- W3199575372 hasRelatedWork W3210868775 @default.
- W3199575372 hasRelatedWork W3213705426 @default.
- W3199575372 hasRelatedWork W377899687 @default.
- W3199575372 hasRelatedWork W4206348372 @default.
- W3199575372 hasRelatedWork W4224327237 @default.
- W3199575372 hasVolume "144" @default.
- W3199575372 isParatext "false" @default.
- W3199575372 isRetracted "false" @default.
- W3199575372 magId "3199575372" @default.
- W3199575372 workType "article" @default.